Journal ArticleDOI
Analog specificity of the thyrotropin-releasing hormone receptor in the central nervous system: possible clinical implications.
E.F. Hawkins,W.K. Engel +1 more
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TLDR
It is hypothesized that the acute transmitter-like action of DN-1417, TRH, and possibly other TRH-analogs and products on LMNs is via a non-TRH receptor, such as an amine or amino acid neurotransmitter receptor, e.g. a 5-hydroxytryptamine receptor.About:
This article is published in Life Sciences.The article was published on 1985-02-11. It has received 42 citations till now. The article focuses on the topics: Thyrotropin-releasing hormone receptor & Central nervous system.read more
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Journal ArticleDOI
The biology of pro-thyrotropin-releasing hormone-derived peptides.
TL;DR: I. Biosynthesis of TRH and Other pro-TRH-Derived Peptide Receptors, and the role of PCs and CPs and Neuropeptide and catecholamine regulation of Pro- TRH biosynthesis and processing.
Journal ArticleDOI
Inhibition of inositol phospholipid breakdown by D2 dopamine receptors in dissociated bovine anterior pituitary cells.
SH Simmonds,Philip G. Strange +1 more
TL;DR: The D2 receptors on these cells are linked to inhibition of inositol phospholipid metabolism, and this provides a functional assay for the receptor.
Journal ArticleDOI
Central nervous system action of TRH to influence gastrointestinal function and ulceration
TL;DR: Converging neuropharmacological, neuroanatomical, and physiological findings support the concept that TRH in the dorsal vagal complex may play a physiological role in the vagal regulation of gastrointestinal function.
Journal ArticleDOI
Medullary sites of action of the TRH analogue, RX 77368, for stimulation of gastric acid secretion in the rat.
TL;DR: Results demonstrate that the dorsal vagal complex and nucleus ambiguus are TRH sites of action for stimulation of gastric acid secretion through vagal dependent pathways, and suggest a possible role of medullary TRH in the vagal regulation of gastrics acid secretion.
Journal ArticleDOI
The effects of the TRH metabolite cyclo(His-Pro) and its analogs on feeding
Lee-Ming Kow,Donald W. Pfaff +1 more
TL;DR: Interestingly, one cHP analog reversed the suppressive effect and stimulated feeding, which suggests that the cHP effect on feeding does require specific structural features.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Attractions of Proteins for Small Molecules and Ions
TL;DR: The number and variety of known compounrjs between proteins and small molecules are increasing rapidly and make a fascinating story as discussed by the authors, and there are many compounds of serum albumin, which was used during the war by many chemists, most of whom found at least one 6ew compound.
Journal ArticleDOI
Immunohistochemical support for three putative transmitters in one neuron: Coexistence of 5-hydroxytryptamine, substance p- and thyrotropin releasing hormone-like immunoreactivity in medullary neurons projecting to the spinal cord
Olle Johansson,T. Hökfelt,B. Pernow,S.L. Jeffcoate,N. White,Harry W.M. Steinbusch,Albert A.J. Verhofstad,Piers C. Emson,E. Spindel +8 more
TL;DR: Evidence was obtained that at least some cell bodies in the medullary raphe nuclei and adjacent areas contained all three compounds, 5-hydroxytryptamine, thyrotropin releasing hormone (TRH) and substance P immunoreactive neurons in normal and colchicine-treated rats.
Journal ArticleDOI
Two distinct central serotonin receptors with different physiological functions
TL;DR: The limited correlation of drug effects with regulation by guanine nucleotides suggests that serotonin 1 sites might be linked to adenylate cyclase and drug specificities of serotonin-elicited synaptic inhibition and excitation may reflect serotonin 1 and serotonin 2 receptor interactions.
Related Papers (5)
Innervation of the nucleus of the solitary tract and the dorsal vagal nucleus by thyrotropin-releasing hormone-containing raphe neurons
Neuropeptides as central integrators of autonomic nerve activity: effects of TRH, SRIF, VIP and bombesin on gastric and adrenal nerves
Hiroaki Somiya,Teiichiro Tonoue +1 more