Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches.
Matthew G Krebs,Jian-Mei Hou,Robert Sloane,Lee Lancashire,Lynsey Priest,Daisuke Nonaka,Timothy H Ward,Alison Backen,Glen Clack,Andrew Hughes,Andrew Hughes,Malcolm R Ranson,Fiona H Blackhall,Caroline Dive,Caroline Dive +14 more
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TLDR
In this paper, the authors compared an epithelial marker-dependent (CellSearch) and a marker-independent (isolation by size of epithelial tumor cells [ISET]) technology platform for the ability to identify CTCs.About:
This article is published in Journal of Thoracic Oncology.The article was published on 2012-02-01 and is currently open access. It has received 389 citations till now. The article focuses on the topics: Circulating tumor cell & Epithelial cell adhesion molecule.read more
Citations
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Journal ArticleDOI
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more
TL;DR: A role for EMT in the blood-borne dissemination of human breast cancer is supported as both single cells and multicellular clusters, expressing known EMT regulators, including transforming growth factor (TGF)–β pathway components and the FOXC1 transcription factor.
Journal ArticleDOI
A microfluidic device for label-free, physical capture of circulating tumor cell clusters
A. Fatih Sarioglu,Nicola Aceto,Nikola Kojic,Maria C. Donaldson,Mahnaz Zeinali,Bashar Hamza,Amanda Engstrom,Huili Zhu,Tilak K. Sundaresan,David T. Miyamoto,Xi Luo,Aditya Bardia,Ben S. Wittner,Sridhar Ramaswamy,Toshi Shioda,David T. Ting,Shannon L. Stott,Ravi Kapur,Shyamala Maheswaran,Daniel A. Haber,Mehmet Toner +20 more
TL;DR: A microchip technology (the Cluster-Chip) is developed to capture CTC clusters independently of tumor-specific markers from unprocessed blood to enable the detailed characterization of their biological properties and role in metastasis.
Journal ArticleDOI
Progress and prospects of early detection in lung cancer
Sean Knight,Phil A. Crosbie,Haval Balata,Jakub Chudziak,Tracy Hussell,Caroline Dive,Caroline Dive +6 more
TL;DR: Despite significant developments in the oncological management of late stage lung cancer over recent years, survival remains poor and the UK Office for National Statistics reported that patients diagnosed with distant metastatic disease had a 1-year survival rate of just 15–19% compared with 81–85% for stage I.
Journal ArticleDOI
Molecular analysis of circulating tumour cells—biology and biomarkers
TL;DR: How circulating tumour cells (CTCs), captured from a minimally invasive blood test—and readily amenable to serial sampling—have the potential to inform intratumour heterogeneity and tumour evolution is described, although it remains to be determined how useful this will be in the clinic.
Journal ArticleDOI
Sensitive capture of circulating tumour cells by functionalized graphene oxide nanosheets
Hyeun Joong Yoon,Tae Hyun Kim,Zhuo Zhang,Ebrahim Azizi,Trinh Pham,Costanza Paoletti,Jules Lin,Nithya Ramnath,Max S. Wicha,Daniel F. Hayes,Diane M. Simeone,Sunitha Nagrath +11 more
TL;DR: An effective approach to isolate CTCs from blood samples of pancreatic, breast and lung cancer patients is demonstrated by using functionalised graphene oxide nanosheets on a patterned gold surface.
References
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Journal ArticleDOI
Epithelial–mesenchymal transitions in tumour progression
TL;DR: Epithelial–mesenchymal transition provides a new basis for understanding the progression of carcinoma towards dedifferentiated and more malignant states.
Journal ArticleDOI
Circulating Tumor Cells, Disease Progression, and Survival in Metastatic Breast Cancer
Massimo Cristofanilli,G. Thomas Budd,Matthew J. Ellis,Alison Stopeck,Jeri Matera,M. Craig Miller,James M. Reuben,Gerald V. Doyle,W. Jeffrey Allard,Leon W.M.M. Terstappen,Daniel F. Hayes +10 more
TL;DR: The number of circulating tumor cells before treatment is an independent predictor of progression-free survival and overall survival in patients with metastatic breast cancer.
Journal ArticleDOI
Complex networks orchestrate epithelial–mesenchymal transitions
TL;DR: Understanding how mesenchymal cells arise from an epithelial default status will also have a strong impact in unravelling the mechanisms that control fibrosis and cancer progression.
Journal ArticleDOI
Collective cell migration in morphogenesis, regeneration and cancer
Peter Friedl,Darren Gilmour +1 more
TL;DR: Comparing different types of collective migration at the molecular and cellular level reveals a common mechanistic theme between developmental and cancer research.
Journal ArticleDOI
Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases.
W. Jeffrey Allard,Jeri Matera,M. Craig Miller,Madeline Repollet,Mark Connelly,Chandra Rao,Arjan G.J. Tibbe,Jonathan W. Uhr,Leon W.M.M. Terstappen +8 more
TL;DR: The CellSearch system can be standardized across multiple laboratories and may be used to determine the clinical utility of CTCs, which are extremely rare in healthy subjects and patients with nonmalignant diseases but present in various metastatic carcinomas with a wide range of frequencies.
Related Papers (5)
Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition
Min Yu,Aditya Bardia,Ben S. Wittner,Shannon L. Stott,Malgorzata E. Smas,David T. Ting,Steven J. Isakoff,Jordan C. Ciciliano,Marissa N. Wells,Ajay Shah,Kyle Concannon,Maria C. Donaldson,Lecia V. Sequist,Elena F. Brachtel,Dennis C. Sgroi,José Baselga,Sridhar Ramaswamy,Mehmet Toner,Daniel A. Haber,Daniel A. Haber,Shyamala Maheswaran +20 more