Journal ArticleDOI
Ancestral haplotypes: conserved population MHC haplotypes.
Mariapia A. Degli-Esposti,Anne L. Leaver,Frank T. Christiansen,Campbell S. Witt,Lawrence J. Abraham,Roger L. Dawkins +5 more
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TLDR
A number of Caucasoid MHC haplotypes that extend from HLA-B to DR and that have been conserved en bloc are described, which may be relevant to antigen presentation, autoimmune responses, and transplantation rejection.About:
This article is published in Human Immunology.The article was published on 1992-08-01. It has received 249 citations till now. The article focuses on the topics: Transplantation & Haplotype.read more
Citations
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Journal ArticleDOI
The HLA genomic loci map: expression, interaction, diversity and disease
TL;DR: The degrees and types of HLA super-locus coordinated gene expression profiles and gene variations have yet to be fully elucidated, integrated and defined for the processes involved with normal cellular and tissue physiology, inflammatory and immune responses, and autoimmune and infectious diseases.
Journal ArticleDOI
Defining the Role of the MHC in Autoimmunity: A Review and Pooled Analysis
Michelle M. A. Fernando,Christine Stevens,Emily C. Walsh,Philip L. De Jager,Philip L. De Jager,Philip L. De Jager,Philippe Goyette,Robert M. Plenge,Robert M. Plenge,Timothy J. Vyse,John D. Rioux,John D. Rioux +11 more
TL;DR: A number of interesting commonalities and differences across diseases that implicate both general and disease-specific pathogenetic mechanisms in autoimmunity are found.
Journal ArticleDOI
The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases
Patricia Price,Campbell S. Witt,Richard J.N. Allcock,David Sayer,Michael J. Garlepp,C.C. Kok,Martyn A. French,Simon Mallal,Frank T. Christiansen +8 more
TL;DR: Several candidate genes in the central MHC have the potential to modulate immune or inflammatory responses in an antigen‐independent manner, as is seen in studies of cultured cells from healthy carriers of the 8.1 AH.
Journal ArticleDOI
A polymorphic variation in a putative regulation box of the TNFA promoter region
TL;DR: These findings suggest that TNFA expression depends on polymorphic variations in linkage disequilibrium with the above HLA markers, and the best candidate would be a polymorphic variation in the promoter region of the TNFA gene itself.
Journal ArticleDOI
Genomics of the major histocompatibility complex: haplotypes, duplication, retroviruses and disease
Roger L. Dawkins,C. Leelayuwat,C. Leelayuwat,Silvana Gaudieri,Silvana Gaudieri,Guan K. Tay,Jennie Hui,S.K. Cattley,Patricia Martinez,Jerzy K. Kulski +9 more
TL;DR: A model of the evolution of the human MHC is proposed and explanations for co‐occurrence of genomic polymorphism, duplication and HERVs are considered and it is asked how these features encode susceptibility to numerous and very diverse diseases.
References
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Journal ArticleDOI
Genetic polymorphism in human glycine-rich beta-glycoprotein.
TL;DR: Electrophoretic studies of fragments from defined types of GBG suggested that GBG cleavage induced by complement or properdin activation in serum occurred through this C moiety, since two variants were detectable in one fragment and two were found in the other fragment.
Journal ArticleDOI
Extended HLA/complement allele haplotypes: evidence for T/t-like complex in man.
TL;DR: In this paper, the distribution of alleles for HLA-A, B, C, D, BF, C2, C4A, and C4B markers were found to occur in haplotypes at frequencies significantly higher than expected.
Extended HLA/complement allele haplotypes: Evidence for T/t-like complex in man (major histocompatibility complex/linkage disequilibrium/t locus/transmission bias)
Z. L. AWDEHt,E. J. Yunis +1 more
TL;DR: The chromosomal distribution of alleles for HLA-A,B,C, and -DR and the serum complement protein alleles of factor B and C2 and C4 was studied in normal Caucasian families and it is suggested that this GLO 2-marked chromosome is a human analog of a murine t mutant.
Journal ArticleDOI
Disease associations with complotypes, supratypes and haplotypes.
Roger L. Dawkins,F.T. Christiansen,P. H. Kay,M.J. Garlepp,James McCluskey,Peter Hollingsworth,P. J. Zilko +6 more
TL;DR: A model for the pathogenesis of sacroiliitis and AS is proposed and two non-linked genes which act stepwise upon HLA-B27 are postulated.
Journal ArticleDOI
An approach to the localization of the susceptibility genes for generalized myasthenia gravis by mapping recombinant ancestral haplotypes.
Mariapia A. Degli-Esposti,A. Andreas,Frank T. Christiansen,Bernd Schalke,Ekkehard D. Albert,Roger L. Dawkins +5 more
TL;DR: A region between HLA B and TNF may be immunoregulatory, whereas the second, located in the class II region, may relate to the inducing factor (e. g., DR1 or DR7 in D-PenMG).
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