Journal ArticleDOI
Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition.
Vivek Dhar Dwivedi,Shiv Bharadwaj,Sumbul Afroz,Nooruddin Khan,Mairaj Ahmed Ansari,Umesh Yadava,Ramesh Chandra Tripathi,I. P. Tripathi,Suman K Mishra,Sang Gu Kang +9 more
TLDR
The antiviral assay showed dose dependent inhibition of DENV-2 infectivity by the selected compounds while maximum 77.7% and 66.2% viral inhibition were recorded for 100 µM kaempferol 3-O-β-rutinoside and 1000 ²M epicatechin, respectively without significant cell toxicity.Abstract:
Dengue virus (DENV) serine protease enzyme, i.e. NS2B-NS3pro (non-structural protein 2B-non-structural protein 3) has been approved as prime drug target for the drug discovery against dengue infect...read more
Citations
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Identification of an effective fraction from Ampelopsis radix with anti-dengue virus activities in vitro and in vivo.
Chunyang Tian,He-Guang Huang,Yuanru Zheng,Xuemei He,Lijun Yan,Ling-zhu Shi,Tang Yang,Xin Chen,Jiabin Yang,Zibin Lu,Huihui Cao,Wei Xing Zhao,Zhiran Qin,Jianhai Yu,Qingfa Tang,Xian-li Tong,Junshan Liu,Linzhong Yu +17 more
TL;DR: Wang et al. as discussed by the authors explored the anti-DENV activities of the fraction (AR-1) obtained from Ampelopsis Radix both in vitro and in vivo, and the chemical composition of AR-1 was identified by liquid chromatography-tandem MS (LC‒MS/MS).
Journal ArticleDOI
Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections: In silico vs. In vitro approach
Harun Norshidah,Chiuan Herng Leow,Kamarulzaman Ezatul Ezleen,Habibah A. Wahab,Ramachandran Vignesh,Azhar Rasul,Ngit Shin Lai +6 more
TL;DR: In this paper , the authors discuss recent strategies for searching for novel DENV NS2B/NS3 protease inhibitors from the in silico and in vitro perspectives, either by applying one of the approaches or by integrating both.
Journal ArticleDOI
Inhibitory Potential of Chromene Derivatives on Structural and Non-Structural Proteins of Dengue Virus
Babitha Thekkiniyedath Dharmapalan,Raja Biswas,Sathianarayanan Sankaran,Baskar Venkidasamy,Muthu Thiruvengadam,Ginson George,Maksim Rebezov,Gokhan Zengin,Monica Gallo,Domenico Montesano,Daniele Naviglio,Mohammad Sharifi +11 more
TL;DR: In this paper , the anti-dengue virus potential of various 4H chromene derivatives was analyzed and in silico, in vitro, and in vivo reports of these scaffolds against the dengue viruses are detailed in the present manuscript.
References
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Scalable algorithms for molecular dynamics simulations on commodity clusters
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