Journal ArticleDOI
Anti-dengue infectivity evaluation of bioflavonoid from Azadirachta indica by dengue virus serine protease inhibition.
Vivek Dhar Dwivedi,Shiv Bharadwaj,Sumbul Afroz,Nooruddin Khan,Mairaj Ahmed Ansari,Umesh Yadava,Ramesh Chandra Tripathi,I. P. Tripathi,Suman K Mishra,Sang Gu Kang +9 more
TLDR
The antiviral assay showed dose dependent inhibition of DENV-2 infectivity by the selected compounds while maximum 77.7% and 66.2% viral inhibition were recorded for 100 µM kaempferol 3-O-β-rutinoside and 1000 ²M epicatechin, respectively without significant cell toxicity.Abstract:
Dengue virus (DENV) serine protease enzyme, i.e. NS2B-NS3pro (non-structural protein 2B-non-structural protein 3) has been approved as prime drug target for the drug discovery against dengue infect...read more
Citations
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Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indica.
Vivek Dhar Dwivedi,Ankita Singh,Sherif Aly El-Kafraway,Thamir A. Alandijany,Arwa A. Faizo,Leena H. Bajrai,Mohammad Amjad Kamal,Mohammad Amjad Kamal,Esam I. Azhar +8 more
TL;DR: In this article, the crystal structure of Japanese encephalitis (JE) virus and bioflavonoids reported in Azadirachta indica were retrieved from specific databases.
Journal ArticleDOI
Inhibitory insights of strawberry (Fragaria × ananassa var. Seolhyang) root extract on tyrosinase activity using computational and in vitro analysis.
TL;DR: In vitro functional assays support in silico predicted results in terms of substantial cytoprotective and cellular antioxidant potential in Raw 264 and non-significant toxicity in zebrafish and can be used in medicinal or cosmetic applications.
Journal ArticleDOI
DenvInD: dengue virus inhibitors database for clinical and molecular research.
Vivek Dhar Dwivedi,Aditya Arya,Pardeep Yadav,Rajesh Kumar,Vinod Kumar,Gajendra P. S. Raghava +5 more
TL;DR: DenvInD as mentioned in this paper is a database for experimentally validated DENV inhibitors against its known targets, which is hosted at https://webs.iiitd.edu.in/raghava/denvind/.
Journal ArticleDOI
Computational and In Vitro Experimental Investigations Reveal Anti-Viral Activity of Licorice and Glycyrrhizin against Severe Acute Respiratory Syndrome Coronavirus 2
Ahmed M. Tolah,Lamya M. Altayeb,Thamir A. Alandijany,Vivek Dhar Dwivedi,Sherif El-Kafrawy,Esam I. Azhar +5 more
TL;DR: In this article, a total 179 phytochemicals of licorice (Glycyrrhiza glabra) were screened and scrutinized against the SARS-CoV-2 main protease (Mpro) with considerable binding affinities in the range of −9.831 to −2.710 kcal/mol.
Journal ArticleDOI
Ayurvedic and Other Herbal Remedies For Dengue: An Update
TL;DR: A comprehensive overview of dengue virus infections, clinical symptoms, diagnosis, mitigation, and treatments, focusing on ayurvedic and herbal remedies, is provided in this article , where Carica papaya, Cissampelos pareira, etc.
References
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Proceedings ArticleDOI
Scalable algorithms for molecular dynamics simulations on commodity clusters
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