Journal ArticleDOI
Anti-inflammatory effects of schisandrin isolated from the fruit of Schisandra chinensis Baill
Lian Yu Guo,Tran Manh Hung,KiHwan Bae,Eun Myoung Shin,Hong Yu Zhou,Yoo Na Hong,Sam Sik Kang,Hyun Pyo Kim,Yeong Shik Kim +8 more
TLDR
In vitro results are the first that show that the anti-inflammatory properties of schisandrin result from the inhibition of nitric oxide production, prostaglandin E(2) (PGE(2)) release, cyclooxygenase-2 (COX-2) and inducible Nitric oxide synthase (iNOS) expression.About:
This article is published in European Journal of Pharmacology.The article was published on 2008-09-04. It has received 198 citations till now. The article focuses on the topics: Schisandrin & Schisandra chinensis.read more
Citations
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Journal ArticleDOI
Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses
Yanyan Yang,Seung Cheol Kim,Tao Yu,Young-Su Yi,Man Hee Rhee,Gi-Ho Sung,Byong Chul Yoo,Jae Youl Cho +7 more
TL;DR: The characteristics of p38 signaling in Macrophage-mediated inflammation are summarized and the potential of using inhibitors targeting p38 expression in macrophages to treat inflammatory diseases is discussed.
Journal ArticleDOI
Diabetes is an inflammatory disease: evidence from traditional Chinese medicines.
TL;DR: Traditional Chinese medicines (TCM) play an important role in lowering blood glucose and controlling inflammation and diverse TCM may share a common antidiabetic property: anti‐inflammatory action.
Journal ArticleDOI
Naturally derived anti-inflammatory compounds from Chinese medicinal plants.
TL;DR: CMM is used clinically to treat inflammation symptoms in TCM, and its effect is mediated by multiple targets through multiple active ingredients, and further studies are warranted to delineate the inflammation actions in more cogency models.
Journal ArticleDOI
Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-κB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells.
Jaemoo Chun,Ran Joo Choi,Salman Khan,Dong-Sung Lee,Youn-Chul Kim,Young-Joo Nam,Dong-Ung Lee,Yeong Shik Kim +7 more
TL;DR: Results suggest that alantolactone exerts its anti-inflammatory effect in LPS-stimulated RAW 264.7 cells by suppressing NF-κB activation and MAPKs phophorylation via downregulation of the MyD88 signaling pathway, and may provide a useful therapeutic approach for inflammation-associated diseases.
Journal ArticleDOI
Ionic liquid-based microwave-assisted extraction of essential oil and biphenyl cyclooctene lignans from Schisandra chinensis Baill fruits.
Chunhui Ma,Tingting Liu,Lei Yang,Yuangang Zu,Xiaoqiang Chen,Lin Zhang,Ying Zhang,Chunjian Zhao +7 more
TL;DR: Ionic liquid-based microwave-assisted extraction (ILMAE) has been successfully applied in extracting essential oil and four kinds of biphenyl cyclooctene lignans from Schisandra chinensis Baill to prove that ILMAE is a better and faster method.
References
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Journal ArticleDOI
Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain.
Karen Seibert,Yan Zhang,Kathleen M. Leahy,Scott D. Hauser,Jaime L. Masferrer,William Perkins,Len F. Lee,Peter C. Isakson +7 more
TL;DR: In an animal model of acute inflammation, a selective inhibitor of COX-2 inhibited edema at the inflammatory site and was analgesic but had no effect on PG production in the stomach and did not cause gastric toxicity.
Journal ArticleDOI
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
Zhijian J. Chen,Jeremiah Hagler,Vito J. Palombella,F. Melandri,D. Scherer,D. Ballard,Tom Maniatis +6 more
TL;DR: Evidence is provided that phosphorylation of serine residues 32 and 36 of I kappa B alpha targets the protein to the ubiquitin-proteasome pathway, which provides a mechanistic link between phosphorylated protein and degradation.
Journal ArticleDOI
Nitric oxide : a key mediator in the early and late phase of carrageenan-induced rat paw inflammation
Daniela Salvemini,Zhi-Qiang Wang,Pamela S. Wyatt,David M. Bourdon,Margaret H. Marino,Pamela T. Manning,Mark G. Currie +6 more
TL;DR: The results suggest that the NO produced by cNOS is involved in the development of inflammation at early time points following carrageenan administration and that No2−/NO3− or PGE2 production in the paw exudate is involvedin the maintenance of the inflammatory response at later time points.
Journal ArticleDOI
The use of changes in capillary permeability in mice to distinguish between narcotic and nonnarcotic analgesics
TL;DR: An extension of the "squirming test" is described which makes the method specific for nonnarcotic analgesics, and shows that drugs that stimulate the central nervous system and also inhibit squirming have no significant effect on leakage of dye over the range of doses which inhibit squirmed.
Journal ArticleDOI
Nitric oxide synthase activity in ulcerative colitis and Crohn's disease.
N.K. Boughton-Smith,S.M. Evans,Brendan J.R. Whittle,Salvador Moncada,Christopher J. Hawkey,A.T. Cole,M. Balsitis +6 more
TL;DR: Induction of colonic NO synthase may be involved in the mucosal vasodilation and increased vascular permeability of active ulcerative colitis, and could also contribute to the impaired motility that accompanies toxic dilation.
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Pharmacology of Schisandra chinensis Bail.: An overview of Russian research and uses in medicine
Alexander Panossian,G. Wikman +1 more