Journal ArticleDOI
Anti-inflammatory properties of plant flavonoids. Effects of rutin, quercetin and hesperidin on adjuvant arthritis in rat.
TLDR
The anti-inflammatory activities of three flavonoids were investigated in rats using the Mizushima et al. model of acute and chronic inflammation, and Rutin was the most active in the chronic phase.Abstract:
The anti-inflammatory activities of three flavonoids were investigated in rats using the Mizushima et al. model of acute and chronic inflammation. Intraperitoneal administration of rutin, quercetin (flavonols) and hesperidin (flavanone), given at daily doses equivalent to 80 mg/kg, inhibited both acute and chronic phases of this experimental model of inflammation. Rutin was the most active in the chronic phase.read more
Citations
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Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.
TL;DR: This review summarizes the known mechanisms involved in the anti-inflammatory activity of flavonoids and the implications of these effects on the protection against cancer and cardiovascular disease.
Journal ArticleDOI
Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid.
TL;DR: Quercetin, a plant pigment is a potent antioxidant flavonoid and more specifically a flavonol, found mostly in onions, grapes, berries, cherries, broccoli, and citrus fruits, it is a versatile antioxidant known to possess protective abilities against tissue injury induced by various drug toxicities.
Journal ArticleDOI
The Pharmacological Potential of Rutin.
Aditya Ganeshpurkar,Ajay Saluja +1 more
TL;DR: The present review highlights current information and health-promoting effects of rutin and safety pharmacology issues and SAR of the same have also been discussed.
Journal ArticleDOI
Antioxidant and anti-inflammatory properties of the citrus flavonoids hesperidin and hesperetin: an updated review of their molecular mechanisms and experimental models.
TL;DR: New findings showed that the antioxidant activity of Hsd/Hst was not only limited to its radical scavenging activity, but it augmented the antioxidant cellular defenses via the ERK/Nrf2 signaling pathway as well.
Journal ArticleDOI
Cinnamon: A Multifaceted Medicinal Plant
TL;DR: Cinnamon is one of the most important spices used daily by people all over the world and is reported to have activities against neurological disorders, such as Parkinson's and Alzheimer's diseases.
References
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Journal ArticleDOI
Review of the biology of quercetin and related bioflavonoids
J.V. Formica,W. Regelson +1 more
TL;DR: The role of flavonoids may transcend their presence in food as mentioned in this paper, however, the amount of quercetin that remains biologically available may not be of sufficient concentration, theoretically, to explain the beneficial effects seen with the Mediterranean diet.
Journal ArticleDOI
Flavonoids : old and new aspects of a class of natural therapeutic drugs
TL;DR: This review summarizes available data on these beneficial effects of flavonoids and suggests that the compounds may possess significant antihepatotoxic, antiallergic, anti-inflammatory, antiosteoporotic and even antitumor activities.
Journal ArticleDOI
Antioxidant and iron-chelating activities of the flavonoids catechin, quercetin and diosmetin on iron-loaded rat hepatocyte cultures
Isabelle Morel,Gérard Lescoat,Pascale Cogrel,Odile Sergent,Nicole Pasdeloup,Pierre Brissot,Pierre Cillard,Josiane Cillard +7 more
TL;DR: The investigation of the capacity of these flavonoids to remove iron from iron-loaded hepatocytes revealed a good relationship between this iron-chelating ability and the cytoprotective effect, increasing the prospects for the development and clinical application of these potent antioxidants.
Journal ArticleDOI
Absorption, metabolism and health effects of dietary flavonoids in man
TL;DR: In this article, the authors performed a study to quantify absorption of various dietary forms of quercetin glycosides from onions and found that the pure aglycone was absorbed far better than the pure Aglycone.