Anti-Inflammatory Small Molecules To Treat Seizures and Epilepsy: From Bench to Bedside
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TLDR
Preclinical studies provide new insights into the regulation of inflammation in epileptic brains and guide drug discovery efforts aimed at developing novel anti-inflammatory therapies for seizures and epilepsy.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2016-06-01 and is currently open access. It has received 149 citations till now. The article focuses on the topics: Epilepsy & Epileptogenesis.read more
Citations
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Journal ArticleDOI
Inflammation in CNS neurodegenerative diseases.
TL;DR: A better understanding of neuroimmune interactions during development and disease will be key to further manipulating these responses and the development of effective therapies to improve quality of life, and reduce the impact of neuroinflammatory and degenerative diseases.
Journal ArticleDOI
Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis
Brienne A. McKenzie,Manmeet K. Mamik,Leina B. Saito,Roobina Boghozian,Roobina Boghozian,Maria Chiara Monaco,Eugene O. Major,Jian-Qiang Lu,William G. Branton,Christopher Power +9 more
TL;DR: Molecular evidence is reported for GSDMD-mediated inflammasome activation and pyroptosis in both myeloid cells and myelin-forming oligodendrocytes in the CNS of patients with MS and in the MS animal model, experimental autoimmune encephalomyelitis (EAE).
Journal ArticleDOI
Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Pavel Klein,Raymond Dingledine,Eleonora Aronica,Christophe Bernard,Ingmar Blümcke,Detlev Boison,Martin J. Brodie,Amy R. Brooks-Kayal,Amy R. Brooks-Kayal,Amy R. Brooks-Kayal,Jerome Engel,Patrick A. Forcelli,Lawrence J. Hirsch,Rafal M. Kaminski,Henrik Klitgaard,Katja Kobow,Daniel H. Lowenstein,Phillip L. Pearl,Asla Pitkänen,Noora Puhakka,Michael A. Rogawski,Dieter Schmidt,Matti Sillanpää,Robert S. Sloviter,Christian Steinhäuser,Annamaria Vezzani,Matthew C. Walker,Wolfgang Löscher +27 more
TL;DR: The identification of impending epilepsy biomarkers to allow better patient selection, together with better alignment with multisite preclinical trials in animal models, should guide the clinical testing of new hypotheses for epileptogenesis and its prevention.
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The vicious circle of hypometabolism in neurodegenerative diseases: Ways and mechanisms of metabolic correction.
Yuri Zilberter,Misha Zilberter +1 more
TL;DR: Results from Published and preliminary experimental results on this approach for treating Alzheimer's disease and epilepsy models support the efficacy of metabolic correction, confirming the highly promising nature of the strategy.
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Cyclooxygenase-2 in glioblastoma multiforme.
TL;DR: Current understanding of COX-2 in GBM proliferation, apoptosis, invasion, angiogenesis, and immunosuppression is highlighted by focusing on recent in vitro and in vivo experimental data.
References
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The role of inflammation in epilepsy
TL;DR: This work focuses on the rapidly growing body of evidence that supports the involvement of inflammatory mediators—released by brain cells and peripheral immune cells—in both the origin of individual seizures and the epileptogenic process.
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Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases
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