Anti-thymocyte globulin induces neoangiogenesis and preserves cardiac function after experimental myocardial infarction
Michael Lichtenauer,Michael Mildner,Gregor Werba,Lucian Beer,Konrad Hoetzenecker,A. Baumgartner,Matthias Hasun,Stefanie Nickl,Andreas Mitterbauer,Matthias Zimmermann,Mariann Gyöngyösi,Bruno K. Podesser,Walter Klepetko,Hendrik Jan Ankersmit +13 more
Reads0
Chats0
TLDR
ATG, a therapeutic agent successfully applied in clinical transplant immunology, triggered cardioprotective effects after AMI that salvaged ischemic myocardium by down-regulation of p53, which might have raised the resistance against apoptotic cell death during ischemia.Abstract:
Rationale
Acute myocardial infarction (AMI) followed by ventricular remodeling is the major cause of congestive heart failure and death in western world countries.read more
Citations
More filters
Journal ArticleDOI
Mesenchymal Stem Cell Therapy for Cardiac Inflammation: Immunomodulatory Properties and the Influence of Toll-Like Receptors
TL;DR: An overview is provided of the effects of DAMP-associated TLR activation on MSC and their immunomodulative properties after myocardial infarction to identify new preconditioning strategies which might improve their immunological properties.
Journal ArticleDOI
Peripheral blood mononuclear cell secretome for tissue repair
TL;DR: The benefits of choosingPBMCs instead of stem cells in regenerative medicine are described and the factors released from apoptotic PBMCs are characterized, which should allow the reader to envision PBMC secretome-based therapies as alternatives to all other forms of cell- based therapies.
Journal ArticleDOI
The secretome of apoptotic human peripheral blood mononuclear cells attenuates secondary damage following spinal cord injury in rats.
Thomas Haider,Romana Höftberger,Beate M. Rüger,Michael Mildner,Roland Blumer,Andreas Mitterbauer,Tanja Buchacher,Camillo Sherif,Patrick Altmann,Heinz Redl,Christian Gabriel,Mariann Gyöngyösi,Michael B. Fischer,Gert Lubec,Hendrik Jan Ankersmit +14 more
TL;DR: Results indicate that factors in MNC-secretome can mitigate the pathophysiological processes of secondary damage after SCI and improve functional outcomes in rats.
Journal ArticleDOI
Elevated Plasma Levels of Interleukin-12p40 and Interleukin-16 in Overweight Adolescents
Michael Lichtenauer,Marcus Franz,Michael Fritzenwanger,Hans-Reiner Figulla,Norbert Gerdes,Christian Jung +5 more
TL;DR: It is believed that the increased levels of IL-12p40 and IL-16 are associated with an ongoing inflammatory response in obese individuals and could lead to the development of disease conditions related to obesity.
Journal ArticleDOI
Elevated plasma levels of interleukin-16 in patients with acute myocardial infarction.
Christiana Schernthaner,Vera Paar,Bernhard Wernly,Rudin Pistulli,Ilonka Rohm,Christian Jung,Hans-Reiner Figulla,Attila Yilmaz,Janne Cadamuro,Elisabeth Haschke-Becher,P. Christian Schulze,Uta C. Hoppe,Michael Lichtenauer,Daniel Kretzschmar +13 more
TL;DR: The cytokine IL-16 might upregulate the proinflammatory response and recruitment of inflammatory cells into infarcted myocardium and correlates with inflammatory cell activation and clinical and biochemical markers.
References
More filters
Journal ArticleDOI
A new mathematical model for relative quantification in real-time RT-PCR.
TL;DR: This study enters into the particular topics of the relative quantification in real-time RT-PCR of a target gene transcript in comparison to a reference gene transcript and presents a new mathematical model that needs no calibration curve.
Journal ArticleDOI
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions
Matthias Nahrendorf,Filip K. Swirski,Elena Aikawa,Lars Stangenberg,Thomas Wurdinger,Jose-Luiz Figueiredo,Peter Libby,Peter Libby,Ralph Weissleder,Mikael J. Pittet +9 more
TL;DR: This work identifies two distinct phases of monocyte participation after MI and proposes a model that reconciles the divergent properties of these cells in healing and identifies new therapeutic targets that can influence healing and ventricular remodeling after MI.
Journal ArticleDOI
Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.
Volker Schächinger,Sandra Erbs,Albrecht Elsässer,Werner Haberbosch,Rainer Hambrecht,Hans Hölschermann,Jiangtao Yu,Roberto Corti,D. G. Mathey,Christian W. Hamm,Tim Suselbeck,Birgit Assmus,Torsten Tonn,Stefanie Dimmeler,Andreas M. Zeiher +14 more
TL;DR: Intracoronary administration of BMC is associated with improved recovery of left ventricular contractile function in patients with acute myocardial infarction and large-scale studies are warranted to examine the potential effects of progenitor-cell administration on morbidity and mortality.
Journal ArticleDOI
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
TL;DR: The potential paracrine mechanisms involved in adult stem cell signaling and therapy are reviewed: cytokines and growth factors can induce cytoprotection and neovascularization, and cardiac remodeling, contractility, and metabolism may also be influenced in aParacrine fashion.
Journal ArticleDOI
Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction.
Ketil Lunde,Svein Solheim,Svend Aakhus,Harald Arnesen,Michael Abdelnoor,Torstein Egeland,Knut Endresen,Arnfinn Ilebekk,Arild Mangschau,J G Fjeld,Hans-Jørgen Smith,Eli Taraldsrud,Haakon K. Grøgaard,Reidar Bjørnerheim,Magne Brekke,Carl Müller,Einar Hopp,Asgrimur Ragnarsson,Jan E. Brinchmann,Kolbjørn Forfang +19 more
TL;DR: A randomized, controlled trial found no effects of intracoronary injection of autologous mononuclear BMC on global left ventricular function.