Anti-tumour promoting activity and antioxidant properties of girinimbine isolated from the stem bark of Murraya koenigii S.
Yih-Yih Kok,L. Y. Mooi,Kartini Ahmad,Mohd Aspollah Sukari,Nashriyah Mat,Mawardi Rahmani,Abdul Manaf Ali +6 more
TLDR
Girinimbine, a carbazole alkaloid isolated from the stem bark of Murraya koenigii was tested for the in vitro anti-tumour promoting and antioxidant activities and was able to inhibit superoxide generation in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiated premyelocytic HL-60 cells.Abstract:
Girinimbine, a carbazole alkaloid isolated from the stem bark of Murraya koenigii was tested for the in vitro anti-tumour promoting and antioxidant activities. Anti-tumour promoting activity was determined by assaying the capability of this compound to inhibit the expression of early antigen of Epstein-Barr virus (EA-EBV) in Raji cells that was induced by the tumour promoter, phorbol 12-myristate 13-acetate. The concentration of this compound that gave an inhibition rate at fifty percent was 6.0 µg/mL and was not cytotoxic to the cells. Immunoblotting analysis of the expression of EA-EBV showed that girinimbine was able to suppress restricted early antigen (EA-R). However, diffused early antigen (EA-D) was partially suppressed when used at 32.0 µg/mL. Girinimbine exhibited a very strong antioxidant activity as compared to a-tocopherol and was able to inhibit superoxide generation in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced differentiated premyelocytic HL-60 cells more than 95%, when treated with the compound at 5.3 and 26.3 µg/mL, respectively. However girinimbine failed to scavenge the stable diphenyl picryl hydrazyl (DPPH)-free radical.read more
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The Wealth of India
TL;DR: The Wealth of India: A Dictionary of Indian Raw Materials and Industrial Products as mentioned in this paper is a dictionary of the economic products of India that was published during the years 1889-99 by the Government of India.
A review on murraya koenigii: multipotential medicinal plant
TL;DR: The ethanobotanical properties, pharmacognostic, phytochemical and pharmacological properties of Murraya koenigii plant are reviewed to verify the efficacy of the plant through scientific biological screening.
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Carbazole scaffolds in cancer therapy: a review from 2012 to 2018.
Samar Issa,Anthony Prandina,Nicolas Bedel,Pal Rongved,Saïd Yous,Marc Le Borgne,Zouhair Bouaziz +6 more
TL;DR: The literature from 2012 to 2018 on the anti-tumour activities reported to carbazole derivatives is explored and the most significant data is critically collected.
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Amino‐Directed RhIII‐Catalyzed CH Activation Leading to One‐Pot Synthesis of NH Carbazoles
TL;DR: One-pot synthesis of N-H carbazoles from unprotected 2-aminobiaryl compounds is reported, where the free amino unit acts as both a directing group for ortho C-H activation and a functional group for construction of an N-heterocyclic ring.
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Phytocarbazoles: alkaloids with great structural diversity and pronounced biological activities
TL;DR: Of particular interest is the cytotoxicity of phytocarbazoles against various cancer cell lines, where some derivatives turned out to act as cell cycle inhibitors and apoptosis inducers and especially the C23 derivative mahanine induced different cell-signaling pathways suggesting that it represents a multi-targeted and multi-functional compound.
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