Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation
Deborah Levine,Allan R. Glanville,C.L Aboyoun,John A. Belperio,Christian Benden,Gerald J. Berry,Ramsey R. Hachem,Don Hayes,Desley Neil,Nancy L. Reinsmoen,Laurie D. Snyder,Stuart C. Sweet,Dolly B. Tyan,Geert Verleden,Glen P. Westall,Roger D. Yusen,Martin R. Zamora,Adriana Zeevi +17 more
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TLDR
A working group was created by the International Society for Heart and Lung Transplantation with the aim of determining criteria for pulmonary AMR and establishing a definition, and diagnostic criteria and a working consensus definition were established.Abstract:
Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no standardized diagnostic criteria or an agreed-upon definition. Hence, a working group was created by the International Society for Heart and Lung Transplantation with the aim of determining criteria for pulmonary AMR and establishing a definition. Diagnostic criteria and a working consensus definition were established. Key diagnostic criteria include the presence of antibodies directed toward donor human leukocyte antigens and characteristic lung histology with or without evidence of complement 4d within the graft. Exclusion of other causes of allograft dysfunction increases confidence in the diagnosis but is not essential. Pulmonary AMR may be clinical (allograft dysfunction which can be asymptomatic) or sub-clinical (normal allograft function). This consensus definition will have clinical, therapeutic and research implications.read more
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Journal ArticleDOI
Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT
Geert Verleden,Allan R. Glanville,Erika D. Lease,Andrew J. Fisher,Fiorella Calabrese,Paul A. Corris,Christopher R. Ensor,Jens Gottlieb,Ramsey R. Hachem,Vibha N. Lama,Tereza Martinu,Desley Neil,Lianne G. Singer,Greg Snell,Robin Vos +14 more
Journal ArticleDOI
Antibody-Mediated Rejection of Solid-Organ Allografts.
TL;DR: This review focuses on current standards for management of antibody-mediated rejection in solid-organ transplant recipients and emphasizes the importance of informed consent for the use of antibodies for organ transplantation.
Journal ArticleDOI
Antibody-mediated rejection across solid organ transplants: manifestations, mechanisms, and therapies
Nicole Valenzuela,Elaine F. Reed +1 more
TL;DR: The clinical and histological manifestations of AMR are described, and the immunopathological mechanisms contributing to antibody-mediated allograft injury as well as current and emerging therapies are discussed.
Journal ArticleDOI
Non-HLA agonistic anti-angiotensin II type 1 receptor antibodies induce a distinctive phenotype of antibody-mediated rejection in kidney transplant recipients
Carmen Lefaucheur,Denis Viglietti,Yassine Bouatou,Aurélie Philippe,Daniele Pievani,Olivier Aubert,Jean-Paul Duong Van Huyen,Jean-Luc Taupin,Denis Glotz,Christophe Legendre,Alexandre Loupy,Philip F. Halloran,Duska Dragun +12 more
TL;DR: Those with AT1R antibody-associated rejection had a higher prevalence of hypertension, more vascular rejection with arterial inflammation, higher levels of endothelial-associated transcripts, and lack of complement deposition in allograft capillaries, which could lead to the development of new treatment strategies to improve allografted survival.
Journal ArticleDOI
Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation.
Sean Agbor-Enoh,Yan Wang,Ilker Tunc,Moon Kyoo Jang,Andrew M. Davis,Iwijn De Vlaminck,Helen Luikart,Pali D. Shah,I. Timofte,Anne Brown,A. Marishta,K. Bhatti,S. Gorham,U. Fideli,Jennifer Wylie,David Grimm,Natalie Goodwin,Yanqin Yang,K. Patel,Jun Zhu,Aldo Iacono,Jonathan B. Orens,Steven D. Nathan,C. Marboe,Gerald J. Berry,Stephen R. Quake,Kiran K. Khush,Hannah A. Valantine +27 more
TL;DR: Lung transplant patients with early unresolving allograft injury measured via donor-derived cell-free DNA are at risk of subsequent allogRAFT injury, which is often clinically silent, and progresses to allografted failure.
References
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Journal ArticleDOI
Revision of the 1990 Working Formulation for the Standardization of Nomenclature in the Diagnosis of Heart Rejection
Susan Stewart,Michael C. Fishbein,G.I. Snell,Gerald J. Berry,Annette Boehler,Margaret Burke,A. Glanville,F. Kate Gould,Cynthia Magro,Charles C. Marboe,K. McNeil,Elaine F. Reed,Nancy L. Reinsmoen,John P. Scott,Sean M. Studer,Henry D. Tazelaar,John Wallwork,G.P. Westall,Martin Zamora,Adriana Zeevi,Samuel A. Yousem +20 more
TL;DR: This article summarizes the revised consensus classification of lung allograft rejection and recommends the evaluation of antibody-mediated rejection, recognizing that this is a controversial entity in the lung, less well developed and understood than in other solid-organ grafts, and with no consensus reached on diagnostic features.
Journal ArticleDOI
Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions
Mark Haas,Banu Sis,Lorraine C. Racusen,Kim Solez,Denis Glotz,Robert B. Colvin,Maria Castro,D. S. R. David,Elias David-Neto,Serena M. Bagnasco,Linda C. Cendales,Lynn D. Cornell,Anthony J. Demetris,Cinthia B. Drachenberg,Carol Farver,Alton B. Farris,Ian W. Gibson,Edward S. Kraus,Helen Liapis,Alexandre Loupy,Volker Nickeleit,Parmjeet Randhawa,E. R. Rodriguez,David N. Rush,Rex Neal Smith,Carmela D. Tan,William D. Wallace,Michael Mengel +27 more
TL;DR: The 12th Banff Conference on Allograft Pathology was held in Comandatuba, Brazil, from August 19-23, 2013, and was preceded by a 2-day Latin American Symposium on Transplant Immunobiology and Immunopathology.
Journal Article
Revision of the 1990 working formulation for the classification of pulmonary allograft rejection : Lung Rejection Study Group
Samuel A. Yousem,Gerald J. Berry,Philip T. Cagle,D. Chamberlain,A. N. Husain,R. H. Hruban,A. Marchevsky,N P Ohori,J. Ritter,S. Stewart,H. D. Tazelaar +10 more
TL;DR: This article summarizes the updated classification for pulmonary allograft rejection, which is based on perivascular and interstitial mononuclear infiltrates and divided into bronchiolitis obliterans--active or inactive--and vascular atherosclerosis--accelerated arterial or venous sclerosis.
Journal ArticleDOI
Evolution and Clinical Pathologic Correlations of De Novo Donor‐Specific HLA Antibody Post Kidney Transplant
Chris Wiebe,Ian W. Gibson,Tom Blydt-Hansen,Martin Karpinski,Julie Ho,Leroy Storsley,Aviva Goldberg,Patricia E. Birk,David N. Rush,Peter Nickerson +9 more
TL;DR: Pathology consistent with antibody‐mediated injury can occur and progress in patients with dnDSA in the absence of graft dysfunction and furthermore, nonadherence and cellular rejection contribute to dNDSA development and progression to graft loss.
Journal ArticleDOI
Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival
Alexandre Loupy,Carmen Lefaucheur,Dewi Vernerey,Christof Prugger,Jean-Paul Duong Van Huyen,Nuala Mooney,Caroline Suberbielle,Véronique Frémeaux-Bacchi,Arnaud Mejean,François Desgrandchamps,Dany Anglicheau,Dominique Nochy,Dominique Charron,Jean-Philippe Empana,Michel Delahousse,Christophe Legendre,Denis Glotz,Gary S. Hill,Adriana Zeevi,Xavier Jouven +19 more
TL;DR: Assessment of the complement-binding capacity of donor-specific anti-HLA antibodies appears to be useful in identifying patients at high risk for kidney-allograft loss.
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