Journal ArticleDOI
Anticlastogenic activity β-carotene against cyclophoshamide in mice in vivo
TLDR
An antagonistic response indicates anticlastogenic activity of BC against cyclophosphamide, which acts as an antimutagen/anticarcinogen in several test systems.About:
This article is published in Mutation Research Letters.The article was published on 1991-05-01. It has received 31 citations till now. The article focuses on the topics: Antimutagen.read more
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Cancer‐Protective Factors in Fruits and Vegetables: Biochemical and Biological Background.
TL;DR: Experimental evidence for the mechanisms of action of cancer-protective agents in fruits and vegetables that protect against initiation include the scavenging effects of polyphenols on activated mutagens and carcinogens, the quenching of singlet oxygen and radicals by carotenoids, and the antioxidant effects of many compounds including ascorbic acid andpolyphenols.
Journal ArticleDOI
Vitamins as antimutagens: advantages and some possible mechanisms of antimutagenic action.
TL;DR: Synergism of some vitamins activity, both with other vitamins and non-vitamin substances, is of particular interest because clarifying some of their mechanisms of action could be important for understanding the functions of the defense systems.
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Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: Role of the modulation of aflatoxin B1 metabolism
TL;DR: In this paper, the effects of carotenoids on the initiation of liver carcinogenesis by aflatoxin B1 (AFB1) were studied in male weanling rats.
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In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids
TL;DR: The water insoluble residues of some carotenoid-rich fruits and vegetables were sequentially extracted with n-hexane, dichloromethane, acetone, and 2-propanol, and solvent extracted materials were tested for inhibition of mutagenicities induced by aflatoxin B1, benzo[a]pyrene, BaP, CP and IQ in histidine-deficient strains of Salmonella typhimurium.
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Bone marrow micronucleus assay: a review of the mouse stocks used and their published mean spontaneous micronucleus frequencies.
TL;DR: This analysis bears out the recommendation of the first Gene‐Tox Report on the micronucleus assay that the historical negative control frequency for a mouse stock should fall between 1 and 3 mnPCE/1,000 and suggests that the recommended range for historical mean frequency should be extended slightly.
References
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Beta-carotene: an unusual type of lipid antioxidant
G. W. Burton,Keith U. Ingold +1 more
TL;DR: New experiments in vitro show that beta-carotene belongs to a previously unknown class of biological antioxidants, and exhibits good radical-trapping antioxidant behavior only at partial pressures of oxygen significantly less than 150 torr, the pressure of oxygen in normal air.
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Can dietary beta-carotene materially reduce human cancer rates?
TL;DR: If dietary β-carotene is truly protective—which could be tested by controlled trials—there are a number of theoretical mechanisms whereby it might act, some of which do not directly involve its ‘provitamin A’ activity.
Journal Article
Chemoprevention of Cancer
TL;DR: This Perspective deals with the areas in cancer control that this field addresses, the promise that it holds, and the problems that must be solved in order to realize its goals.