Antidiabetic and antioxidant properties of alkaloids from Catharanthus roseus (L.) G. Don.
Soon Huat Tiong,Chung Yeng Looi,Hazrina Hazni,Aditya Arya,Mohammadjavad Paydar,Won Fen Wong,Shiau-Chuen Cheah,Mohd Rais Mustafa,Khalijah Awang +8 more
TLDR
In vitro antioxidant and antidiabetic activities of the major alkaloids isolated from Catharanthus roseus (L.) G. Don leaves extract are reported, implying their therapeutic potential against type 2 diabetes.Abstract:
Catharanthus roseus (L.) G. Don is a herbal plant traditionally used by local populations in India, South Africa, China and Malaysia to treat diabetes. The present study reports the in vitro antioxidant and antidiabetic activities of the major alkaloids isolated from Catharanthus roseus (L.) G. Don leaves extract. Four alkaloids—vindoline I, vindolidine II, vindolicine III and vindolinine IV—were isolated and identified from the dichloromethane extract (DE) of this plant's leaves. DE and compounds I-III were not cytotoxic towards pancreatic β-TC6 cells at the highest dosage tested (25.0 µg/mL). All four alkaloids induced relatively high glucose uptake in pancreatic β-TC6 or myoblast C2C12 cells, with III showing the highest activity. In addition, compounds II-IV demonstrated good protein tyrosine phosphatase-1B (PTP-1B) inhibition activity, implying their therapeutic potential against type 2 diabetes. III showed the highest antioxidantread more
Citations
More filters
Journal ArticleDOI
Reactive Oxygen Species and Antioxidant Defense in Plants under Abiotic Stress: Revisiting the Crucial Role of a Universal Defense Regulator
Mirza Hasanuzzaman,M. H. M. Borhannuddin Bhuyan,Faisal Zulfiqar,Ali Raza,Sayed Mohammad Mohsin,Sayed Mohammad Mohsin,Jubayer Al Mahmud,Masayuki Fujita,Vasileios Fotopoulos +8 more
TL;DR: This review has documented the recent advancement illustrating the harmful effects of ROS, antioxidant defense system involved in ROS detoxification under different abiotic stresses, and molecular cross-talk with other important signal molecules such as reactive nitrogen, sulfur, and carbonyl species.
Journal ArticleDOI
Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases.
Cinzia Forni,Francesco Facchiano,Manuela Bartoli,Stefano Pieretti,Antonio Facchiano,Daniela D'Arcangelo,Sandro Norelli,Giorgia Valle,Roberto Nisini,Simone Beninati,Claudio Tabolacci,Ravirajsinh N. Jadeja +11 more
TL;DR: The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.
Journal ArticleDOI
Indole alkaloids from Catharanthus roseus: bioproduction and their effect on human health.
TL;DR: This review is focused on the different strategies which improve TIA production, and in the analysis of the beneficial effects that these compounds exert on human health.
Journal ArticleDOI
Functional Foods and Nutraceuticals as Dietary Intervention in Chronic Diseases; Novel Perspectives for Health Promotion and Disease Prevention.
TL;DR: Different functional food bioactive compounds may synergistically/additively confer an overwhelming protection against these degenerative diseases by modulating/altering the activities of these critical enzymes of physiological importance.
Journal ArticleDOI
Enzymes inhibitors from natural sources with antidiabetic activity: A review.
TL;DR: This review will provide very useful material to enhance the efficiency of rational antidiabetic drug design.
References
More filters
Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal ArticleDOI
Antioxidant activity and phenolic compounds in selected herbs
Wei Zheng,Shiow Y. Wang +1 more
TL;DR: The antioxidant capacities (oxygen radical absorbance capacity, ORAC) and total phenolic contents in extracts of 27 culinary herbs and 12 medicinal herbs were determined and rosmarinic acid was the predominant phenolic compound in selected herbs.
Journal ArticleDOI
Oxygen-radical absorbance capacity assay for antioxidants
TL;DR: A relatively simple but sensitive and reliable method of quantitating the oxygen-radical absorbing capacity (ORAC) of antioxidants in serum using a few microliter is described, which solves many problems associated with kinetics or lag-time measurements.
Journal ArticleDOI
Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus
TL;DR: 86 natural medicines with regards to their origin, anti-diabetic active principles and/or pharmacological test results, which are commonly used in the traditional Chinese medical system and have demonstrated experimental or/and clinical anti-Diabetic effectiveness are reviewed.
Journal ArticleDOI
Effect of an antidiabetic extract of Catharanthus roseus on enzymic activities in streptozotocin induced diabetic rats.
Som Nath Singh,Praveen Vats,Shoba Suri,Radhey Shyam,M. M. L. Kumria,S. Ranganathan,K. Sridharan +6 more
TL;DR: Increased levels of lipid peroxidation measured as 2-thiobarbituric acid reactive substances (TBARS) indicative of oxidative stress in diabetic rats were also normalized by treatment with the extract, indicating increased metabolization of glucose in treated rats.