Journal ArticleDOI
Antioxidant enzymes in the aging human retinal pigment epithelium.
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TLDR
These results represent the first quantitation of catalase activity in human retinal pigment epithelium and show six-fold greater catalases activity in retinal pigments than in other ocular tissues analyzed.Abstract:
• The antioxidant enzymes catalase and superoxide dismutase have integral roles in controlling reactive oxygen radicals that can harm cells. In the present study, we quantitated catalase activity in retinal pigment epithelium, retina, iris, and vitreous from human donors. To our knowledge, our results represent the first quantitation of catalase activity in human retinal pigment epithelium and show six-fold greater catalase activity in retinal pigment epithelium than in other ocular tissues analyzed (Pread more
Citations
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The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
TL;DR: The concept that AMD can be attributed to cumulative oxidative stress is enticing, but remains unproven, and the effect of nutritional antioxidant supplements on the onset and natural course of age-related macular disease is currently being evaluated.
Journal ArticleDOI
Current Concepts in the Pathogenesis of Age-Related Macular Degeneration
TL;DR: Better knowledge of AMD cell biology will lead to better treatments for AMD at all stages of the disease, and multiple animal models and in vitro models of specific aspects of AMD are needed to make rapid progress in developing effective therapies for different stages.
Journal ArticleDOI
Oxidative damage and protection of the RPE.
TL;DR: Results indicate that therapeutic or nutritional intervention to enhance the GSH antioxidant capacity of RPE may provide an effective way to prevent or treat AMD.
Journal ArticleDOI
Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration.
TL;DR: The susceptibility of mtDNA to oxidative damage in human RPE cells, together with the age-related decrease of cellular anti-oxidant system, provides the rationale for a mitochondria-based model of AMD.
Journal ArticleDOI
Consequences of oxidative stress in age-related macular degeneration
TL;DR: It appears that these age- related oxidative changes are a hallmark of early age-related macular degeneration (AMD) which, in combination with hereditary susceptibility and other retinal modifiers, can progress to the pathology and visual morbidity associated with advanced AMD.
References
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Journal ArticleDOI
The catalytic decomposition of hydrogen peroxide by iron salts
Fritz Haber,Joseph Weiss +1 more
TL;DR: Wansbrough-Jones as discussed by the authors gave the manuscript of this paper to Professor Sir William Pope, but the final revision for the press had not been made and in its original from the paper was not suitable for publication in an English journal; but since, Professor Haber had considered carefully how he wished to present the results embodied in it, the form and sequence of the paper remain unmodified.
Journal ArticleDOI
Measurement of catalase activity in tissue extracts.
Journal ArticleDOI
Oxygen metabolism and the toxic properties of phagocytes.
TL;DR: The products of oxygen reduction and excitation and enzymes that potentiate or limit the toxicity of these agents contribute to the complexity of the oxygen-dependent antimicrobial systems of phagocytes.
Journal ArticleDOI
Oxidants from phagocytes: agents of defense and destruction
TL;DR: From the Blood Research Laboratory and the Department of Medicine, Tufts-New England Medical Center.
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