Antiviral peptides against Coronaviridae family: A review.
Hamid Heydari,Reza Golmohammadi,Reza Mirnejad,Hamid Tebyanian,Mahdi Fasihi-Ramandi,Mehrdad Moosazadeh Moghaddam +5 more
Reads0
Chats0
TLDR
In this paper, the authors made an effort to compile and review the antiviral peptides with activity against Coronaviridae family viruses, including binding/attachment inhibitors, fusion and entry inhibitors, viral enzyme inhibitors, replication inhibitors, and peptide with direct and indirect effects on the viruses.Citations
More filters
Journal ArticleDOI
Emerging SARS-CoV-2 variants of concern and potential intervention approaches.
TL;DR: The major variant of concerns (VOCs) have shared mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike proteins, mostly on the S1 unit and resulted in higher transmissibility rate and affect viral virulence and clinical outcome as discussed by the authors.
Journal ArticleDOI
Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2.
TL;DR: In this article , a peptide GSRY was predicted to have better physicochemical properties, and the value of '-C DOCKER interaction energy' between peptide gSRY and SARS-CoV-2 main protease (Mpro) was 80.8505 kcal/mol.
Journal ArticleDOI
Identification of lactoferrin-derived peptides as potential inhibitors against the main protease of SARS-CoV-2.
TL;DR: In this paper, a peptide GSRY was predicted to have better physicochemical properties, and the value of '-C DOCKER interaction energy' between peptide gSRY and SARS-CoV-2 main protease (Mpro) was 80.8505 kcal/mol.
Journal ArticleDOI
Two Different Therapeutic Approaches for SARS-CoV-2 in hiPSCs-Derived Lung Organoids
Paola Spitalieri,Federica Centofanti,Michela Murdocca,Maria Giovanna Scioli,Andrea Latini,Silvia Di Cesare,Gennaro Citro,Antonio Rossi,Augusto Orlandi,Shane Miersch,Sachdev S. Sidhu,Pier Paolo Pandolfi,Annalisa Botta,Federica Sangiuolo,Giuseppe Novelli +14 more
TL;DR: The efficacy of a new tetravalent neutralizing antibody targeting Spike protein and a synthetic peptide homologous to dipeptidyl peptidase-4 (DPP4) receptor on host cells are demonstrated, providing proof-of-principle evidence that hiPSC-derived hLORGs represent an ideal in vitro system for testing both therapeutic and preventive modalities against COVID-19.
Journal ArticleDOI
A contemporary review on the important role of in silico approaches for managing different aspects of COVID-19 crisis
Mohammad Moradi,Reza Golmohammadi,Ali Najafi,Mehrdad Moosazadeh Moghaddam,Mahdi Fasihi-Ramandi,Reza Mirnejad +5 more
TL;DR: In this article , the authors provide a brief outlook regarding the importance of in silico tools in managing different aspects of COVID-19 pandemic infection and how these methods have been helpful to biomedical researchers.
References
More filters
Journal ArticleDOI
Antimicrobial Peptides: Current and Potential Applications in Biomedical Therapies
TL;DR: The wide-ranging functionality of AMPs against infection and disease of the urinary tract expands the list of effects beyond the “antimicrobial effects” originally assigned to them.
Journal ArticleDOI
Human β-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages
Ju Kim,Ye Lin Yang,Yong-Suk Jang +2 more
TL;DR: HBD 2 promotes CCR2-mediated Nod2 signaling, which induces production of type I IFNs and an inflammatory response, and enhances primary innate immunity leading to an effective adaptive immune response to HBD 2-conjugated antigen.
Journal ArticleDOI
Identification of a peptide derived from the heptad repeat 2 region of the porcine epidemic diarrhea virus (PEDV) spike glycoprotein that is capable of suppressing PEDV entry and inducing neutralizing antibodies.
TL;DR: It is demonstrated that the HR2P peptide and anti‐HR2P antibody can serve as a tool for dissecting the fusion mechanism of PEDV, guiding the search for potent inhibitors with therapeutic value against P EDV infection.
Journal ArticleDOI
Swine acute diarrhea syndrome coronavirus (SADS-CoV) antagonizes interferon-β production via blocking IPS-1 and RIG-I
TL;DR: This study is the first investigation that shows interactions between SADS- coV and the host innate immunity, which provides information of the molecular mechanisms underlying SASD-CoV infection.
Journal ArticleDOI
Peptides corresponding to the predicted heptad repeat 2 domain of the feline coronavirus spike protein are potent inhibitors of viral infection.
TL;DR: The data suggest that the synthetic peptide FP5 could serve as a valuable addition to the current FIP prevention methods.