Antivirulence properties of an antifreeze protein.
Martin Heisig,Nabil M. Abraham,Lei Liu,Girish Neelakanta,Sarah Mattessich,Hameeda Sultana,Zhengling Shang,Juliana M. Ansari,Charlotte Killiam,Wendy E. Walker,Lynn Cooley,Richard A. Flavell,Hervé Agaisse,Erol Fikrig,Erol Fikrig +14 more
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TLDR
Data show that an antifreeze protein facilitates host control of bacterial infections and suggest therapeutic strategies for countering pathogens.About:
This article is published in Cell Reports.The article was published on 2014-10-23 and is currently open access. It has received 43 citations till now. The article focuses on the topics: Biofilm.read more
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Pathogen-mediated manipulation of arthropod microbiota to promote infection
Nabil M. Abraham,Nabil M. Abraham,Lei Liu,Brandon L. Jutras,Brandon L. Jutras,Akhilesh K. Yadav,Sukanya Narasimhan,Vissagan Gopalakrishnan,Vissagan Gopalakrishnan,Vissagan Gopalakrishnan,Juliana M. Ansari,Kimberly K. Jefferson,Felipe Cava,Christine Jacobs-Wagner,Erol Fikrig,Erol Fikrig +15 more
TL;DR: The molecular mechanisms by which a human pathogen appropriates an arthropod antibacterial protein to alter the gut microbiota and more effectively colonize the vector are elucidated.
Journal ArticleDOI
From ice-binding proteins to bio-inspired antifreeze materials
TL;DR: This review covers recent advances in the field of ice-binding proteins and their synthetic analogues, focusing on fundamental insights of biological and technological relevance.
Journal ArticleDOI
Recent insights into the tick microbiome gained through next-generation sequencing
Telleasha L. Greay,Alexander W. Gofton,Andrea Paparini,Una Ryan,Charlotte L. Oskam,Peter J. Irwin +5 more
TL;DR: A review of NGS strategies for tick microbiome studies and the recent findings from tick NGS investigations are discussed, including the bacterial diversity and composition, influential factors, and implications of the tick microbiome.
Journal ArticleDOI
Modulation of the tick gut milieu by a secreted tick protein favors Borrelia burgdorferi colonization.
Sukanya Narasimhan,Tim J. Schuijt,Nabil M. Abraham,Nabil M. Abraham,Nallakkandi Rajeevan,Jeroen Coumou,Morven Graham,Andrew Robson,Ming-Jie Wu,Sirlei Daffre,Joppe W. Hovius,Erol Fikrig,Erol Fikrig +12 more
TL;DR: It is shown that a tick secreted protein (PIXR) modulates the tick gut microbiota and facilitates B. burgdorferi colonization and impairs larval molting, indicative of its role in tick biology.
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Counterattacking the tick bite: Towards a rational design of anti-tick vaccines targeting pathogen transmission
Ryan O. M. Rego,Jos J. A. Trentelman,Juan Anguita,Ard M. Nijhof,Hein Sprong,Boris Klempa,Ondrej Hajdusek,Julen Tomás-Cortázar,Tal Azagi,Martin Strnad,Martin Strnad,Sarah Knorr,Radek Sima,Marie Jalovecka,Marie Jalovecka,Sabína Havlíková,Martina Ličková,Monika Sláviková,Petr Kopáček,Petr Kopáček,Libor Grubhoffer,Libor Grubhoffer,Joppe W. Hovius +22 more
TL;DR: The status of current knowledge on the triangular relationships between ticks, the pathogens they carry and the mammalian hosts, as well as methods that are being used to identify anti-tick vaccine candidates that can prevent the transmission of tick-borne pathogens are reviewed.
References
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Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices.
Gordon D. Christensen,W A Simpson,J J Younger,Larry M. Baddour,F F Barrett,D M Melton,E H Beachey +6 more
TL;DR: The optical densities of stained bacterial films adherent to plastic tissue culture plates serve as a quantitative model for the study of the adherence of coagulase-negative staphylococci to medical devices, a process which may be important in the pathogenesis of foreign body infections.
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Immunodesign of experimental sepsis by cecal ligation and puncture.
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The Risk of Bloodstream Infection in Adults With Different Intravascular Devices: A Systematic Review of 200 Published Prospective Studies
TL;DR: These data, based on prospective studies of adults, show that all types of IVDs pose a risk of IVD-related BSI and can be used for benchmarking rates of infection caused by the various types of intravascular devices in use at the present time.
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The Intercellular Adhesion (ica) Locus Is Present in Staphylococcus aureus and Is Required for Biofilm Formation
TL;DR: Investigating a variety of Staphylococcus aureus strains finds that all strains tested contain the ica locus and that several can form biofilms in vitro, suggesting that cell-cell adhesion and the potential to form biofilmms is conserved within this genus.
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Polysaccharide intercellular adhesin (PIA) protects Staphylococcus epidermidis against major components of the human innate immune system
Cuong Vuong,Jovanka M. Voyich,Elizabeth R. Fischer,Kevin R. Braughton,Adeline R. Whitney,Frank R. DeLeo,Michael Otto +6 more
TL;DR: Scanning electron microscopy is used to demonstrate that the exopolysaccharide intercellular adhesin (PIA) resides in fibrous strands on the bacterial cell surface, and that lack of PIA production results in complete loss of the extracellular matrix material that has been suggested to mediate immune evasion.