Journal ArticleDOI
Arecoline Cytotoxicity on Human Oral Mucosal Fibroblasts Related to Cellular Thiol and Esterase Activities
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TLDR
Results indicate that cytotoxicity of arecoline on OMF is associated with cellular GSH levels and esterase activities and factors that induce the GSH synthesis or ester enzyme activity of oral mucosal cells can be used for future chemoprevention of BQ chewing-related lesions.About:
This article is published in Food and Chemical Toxicology.The article was published on 1999-07-01. It has received 47 citations till now. The article focuses on the topics: Arecoline & Buthionine sulfoximine.read more
Citations
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Journal ArticleDOI
Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives
TL;DR: It would appear that AN toxicity is not completely due to its polyphenol, tannin and alkaloid content, and further studies are needed to delineate the metabolism of AN ingredient and their roles in the multi-step chemical carcinogenesis, to enhance the success of the future chemoprevention of oral cancer and oral submucous fibrosis.
Journal ArticleDOI
Stimulation of glutathione depletion, ROS production and cell cycle arrest of dental pulp cells and gingival epithelial cells by HEMA.
Hsiao-Hua Chang,Ming-Kuang Guo,Frederick H. Kasten,Mei-Chi Chang,Guay-Fen Huang,Yin-Lin Wang,Ruey-Song Wang,Jiiang-Huei Jeng +7 more
TL;DR: HEMA-induced growth inhibition in HPF and S-G cells in a dose-dependent manner, which may be partially explained by induction of cell cycle perturbation, helped to define the mechanism of the cytotoxicity caused by HEMA.
Journal ArticleDOI
Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species and mitochondrial membrane potential
Mei Chi Chang,Yuan Soon Ho,P.H. Lee,Chiu-Po Chan,Jang-Jaer Lee,L.J. Hahn,Ying Jen Wang,Jiiang-Huei Jeng +7 more
TL;DR: Results indicate that AN ingredients are crucial in the pathogenesis of oral submucous fibrosis (OSF) and oral cancer by differentially inducing the dysregulation of cell cycle control, Deltabetam, GSH level and intracellular H(2)O( 2) production, these events being not coupled with cellular apoptosis.
Journal ArticleDOI
Oral submucous fibrosis: an update
TL;DR: Treatment of OSF is difficult, as not many large, randomized controlled trials have been conducted, and the principal actions of drug therapy include antifibrotic, anti-inflammatory, and antioxygen radical mechanisms.
Journal ArticleDOI
Immunosuppression, hepatotoxicity and depression of antioxidant status by arecoline in albino mice
Romi Dasgupta,Indraneel Saha,Suman Pal,Arindam Bhattacharyya,Gaurisankar Sa,Tapas Chandra Nag,Tania Das,B.R. Maiti +7 more
TL;DR: It is concluded that arecoline attacks multiple targets to finally generate systemic toxicity in mice and caused depression of antioxidants, i.e., superoxide dismutase (SOD), catalase, reduced glutathione (GSH) and glutATHione-S-transferase (GST) that are known to neutralize reactive oxygen species.
References
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Journal ArticleDOI
IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans
Book ChapterDOI
The Glutathione Status of Cells
TL;DR: GSH status, the biologically relevant chemistry of GSH, the forms in which GSH can be present within the cell, along with the GSH content of cells and the methods for analysis of this substance are discussed.
Journal ArticleDOI
Regulation of cellular glutathione.
Susan M. Deneke,Barry L. Fanburg +1 more
TL;DR: High levels of cellular GSH levels in cultured cells in response to hyperoxia or electrophilic agents such as diethylmaleate is coupled with an increase in activity of the Xc- transport system for the amino acids cystine and glutamate.
Journal ArticleDOI
Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione.
P G Richman,A Meister +1 more
TL;DR: The finding that glutathione regulates its own synthesis by inhibiting synthesis of gamma-glutamyl-cysteine appears to explain observations on patients with 5-oxoprolinuria, who were shown to have a block in the gamma- GLUTamyl cycle consisting of a marked deficiency of glutathion synthetase.
Journal ArticleDOI
Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors.
TL;DR: A statistical analysis of sociodemographic factors showed that lesser educated older men, blue collar workers, smokers and drinkers were the likeliest betel chewers.