Journal ArticleDOI
Aromatic C–H coupling with hindered arylboronic acids by Pd/Fe dual catalysts
TLDR
In this article, an aerobic coupling of arenes/alkenes with arylboronic acids (C-H/C-B coupling) using catalytic Pd(II)-sulfoxide-oxazoline (sox) ligand and iron-phthalocyanine (FePc) has been developed.Abstract:
An aerobic oxidative coupling of arenes/alkenes with arylboronic acids (C–H/C–B coupling) using catalytic Pd(II)–sulfoxide–oxazoline (sox) ligand and iron–phthalocyanine (FePc) has been developed. This dual catalyst system enables the synthesis of sterically hindered heterobiaryls and styrene derivatives under air without stoichiometric co-oxidants. Additionally, this chemistry demonstrated an advance toward an enantioselective biaryl coupling through C–H functionalization.read more
Citations
More filters
Journal ArticleDOI
Catalytic Enantioselective Transformations Involving C-H Bond Cleavage by Transition-Metal Complexes.
TL;DR: This analysis comprehensively review all asymmetric transition-metal-catalyzed methodologies that are believed to proceed via an inner-sphere-type mechanism, with an emphasis on the nature of stereochemistry generation.
Journal ArticleDOI
Enantioselective and Enantiospecific Transition-Metal-Catalyzed Cross-Coupling Reactions of Organometallic Reagents To Construct C–C Bonds
TL;DR: This work states that the stereocontrolled construction of C−C bonds remains one of the foremost challenges in organic synthesis and has resulted in a paradigm shift in synthetic strategy planning.
Journal ArticleDOI
Recent advances and new concepts for the synthesis of axially stereoenriched biaryls
TL;DR: These outstanding steps further unlocked the door to the preparation of previously difficult-to-access precursors of privileged ligands like BINOL, BINAM, QUINAP and many other molecules of interest.
Journal ArticleDOI
Synthesis of extended π-systems through C-H activation.
TL;DR: This Review focuses on recently reported π-extending C-H activation reactions directed toward new optoelectronic conjugated materials.
Journal ArticleDOI
Recent development of direct asymmetric functionalization of inert C–H bonds
Chao Zheng,Shu-Li You +1 more
TL;DR: The area of direct asymmetric functionalization of inert C-H bonds has attracted considerable attention in recent years as discussed by the authors, and a lot of strategies have emerged including asymmetric C−H bond insertion by metal carbenoids or analogs, cross dehydrogenative coupling, [1,5]-hydride transfer, C-h bond functionalization involving a transient metal-carbon species and other miscellaneous methods.
References
More filters
Journal ArticleDOI
Palladium(II)-catalyzed C-H activation/C-C cross-coupling reactions: versatility and practicality.
TL;DR: A review of palladium-catalyzed coupling of CH bonds with organometallic reagents through a PdII/Pd0 catalytic cycle can be found in this paper.
Journal ArticleDOI
Aryl-aryl bond formation by transition-metal-catalyzed direct arylation.
TL;DR: A number of improvements have developed the former process into an industrially very useful and attractive method for the construction of aryl -aryl bonds, but the need still exists for more efficient routes whereby the same outcome is accomplished, but with reduced waste and in fewer steps.
Journal ArticleDOI
Transition-metal-catalyzed direct arylation of (hetero)arenes by C-H bond cleavage.
TL;DR: P palladium and ruthenium catalysts have been described that enable the direct arylation of (hetero)arenes with challenging coupling partners--including electrophilic aryl chlorides and tosylates as well as simple arenes in cross-dehydrogenative arylations.
Journal ArticleDOI
C-H bond functionalization: emerging synthetic tools for natural products and pharmaceuticals
TL;DR: This Review provides an overview of C-H bond functionalization strategies for the rapid synthesis of biologically active compounds such as natural products and pharmaceutical targets.