Journal ArticleDOI
Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial.
Reads0
Chats0
TLDR
Artesunate should become the treatment of choice for severe falciparum malaria in adults because it is more rapidly acting than intravenous quinine in terms of parasite clearance and is simpler to administer.About:
This article is published in The Lancet.The article was published on 2005-01-01. It has received 944 citations till now. The article focuses on the topics: Artesunate & Quinine.read more
Citations
More filters
Journal ArticleDOI
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more
TL;DR: The overall median clearance times were 84 hours (interquartile range, 60 to 96) in Pailin and 48 hours in Wang Pha (P<0.001) in each of the two locations as discussed by the authors.
Summary of product characteristics
Helen Andrew,Gemma Gossedge,Julie Croft,Neil Corrigan,Julia Brown,Nicholas West,Philip Quirke,Damian Tolan,Ronan A. Cahill,David Jayne +9 more
TL;DR: Trimetazidine is indicated in adults as add-on therapy for the symptomatic treatment of patients with stable angina pectoris who are inadequately controlled by or intolerant to first-line antianginal therapies.
Journal ArticleDOI
Qinghaosu (artemisinin): the price of success.
TL;DR: Artemisinin combination treatments are now first-line drugs for uncomplicated falciparum malaria, but access to ACTs is still limited in most malaria-endemic countries and a global subsidy would make these drugs more affordable and available.
Journal ArticleDOI
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.
Arjen M. Dondorp,Caterina I. Fanello,Ilse C. E. Hendriksen,Ermelinda Gomes,Amir Seni,Kajal D. Chhaganlal,Kalifa Bojang,Rasaq Olaosebikan,Nkechinyere Anunobi,Kathryn Maitland,Esther Kivaya,Tsiri Agbenyega,Samuel Blay Nguah,Jennifer R Evans,Samwel Gesase,Catherine Kahabuka,George Mtove,Behzad Nadjm,Jacqueline L. Deen,Juliet Mwanga-Amumpaire,Margaret Nansumba,Corine Karema,Noella Umulisa,Aline Uwimana,Olugbenga A. Mokuolu,Olanrewaju T. Adedoyin,W B Johnson,Antoinette Tshefu,Marie A. Onyamboko,Tharisara Sakulthaew,Wirichada Pan Ngum,Kamolrat Silamut,Kasia Stepniewska,Charles J. Woodrow,D. Bethell,Bridget Wills,Martina Oneko,Tim E. A. Peto,Lorenz von Seidlein,Nicholas P. J. Day,Nicholas J. White +40 more
TL;DR: Parenteral artesunate should replace quinine as the treatment of choice for severe falciparum malaria worldwide, according to evidence from Asia, and substantially reduces mortality in African children with severe malaria.
Journal ArticleDOI
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria
Jane Achan,Ambrose Talisuna,Annette Erhart,Adoke Yeka,James K Tibenderana,Frederick N. Baliraine,Philip J. Rosenthal,Umberto D'Alessandro +7 more
TL;DR: In pregnancy, quinine continues to play a critical role in the management of malaria, especially in the first trimester, and it will remain a mainstay of treatment until safer alternatives become available.
References
More filters
Journal ArticleDOI
Interaction revisited: the difference between two estimates
Douglas G. Altman,J M Bland +1 more
TL;DR: Interference is considered in terms of heterogeneity of treatment effect in subgroups in a randomised trial, such as two age groups, and interaction more generally.
Journal ArticleDOI
Artesunate combinations for treatment of malaria: meta-analysis
TL;DR: The addition of 3 days of artesunate to standard antimalarial treatments substantially reduce treatment failure, recrudescence, and gametocyte carriage.
Journal ArticleDOI
The Treatment of Malaria
TL;DR: Clinical manifestations of severe malaria are hypoglycemia, convulsions, severe anemia, acute renal failure, jaundice, pulmonary edema, cerebral malaria, shock, and acidosis.
Journal ArticleDOI
Severe Hypoglycemia and Hyperinsulinemia in Falciparum Malaria
Nicholas J. White,David A. Warrell,Pornthep Chanthavanich,Sornchai Looareesuwan,M. J. Warrell,Sanjeev Krishna,Dermot H. Williamson,Robert C. Turner +7 more
TL;DR: Observations indicate that in falciparum malaria quinine-induced insulin secretion may precipitate hypoglycemia, but other factors, including the large glucose requirements of the malaria parasites may also contribute.
Journal ArticleDOI
A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria.
T H Tran,Nicholas P. J. Day,H P Nguyen,T H Nguyen,P L Pham,X S Dinh,V C Ly,V Ha,D Waller,Tim E. A. Peto,Nicholas J. White +10 more
TL;DR: Artemether is a satisfactory alternative to quinine for the treatment of severe malaria in adults in Vietnam and is associated with a higher risk of hypoglycemia, but there were no other serious side effects in either group.
Related Papers (5)
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trial.
Arjen M. Dondorp,Caterina I. Fanello,Ilse C. E. Hendriksen,Ermelinda Gomes,Amir Seni,Kajal D. Chhaganlal,Kalifa Bojang,Rasaq Olaosebikan,Nkechinyere Anunobi,Kathryn Maitland,Esther Kivaya,Tsiri Agbenyega,Samuel Blay Nguah,Jennifer R Evans,Samwel Gesase,Catherine Kahabuka,George Mtove,Behzad Nadjm,Jacqueline L. Deen,Juliet Mwanga-Amumpaire,Margaret Nansumba,Corine Karema,Noella Umulisa,Aline Uwimana,Olugbenga A. Mokuolu,Olanrewaju T. Adedoyin,W B Johnson,Antoinette Tshefu,Marie A. Onyamboko,Tharisara Sakulthaew,Wirichada Pan Ngum,Kamolrat Silamut,Kasia Stepniewska,Charles J. Woodrow,D. Bethell,Bridget Wills,Martina Oneko,Tim E. A. Peto,Lorenz von Seidlein,Nicholas P. J. Day,Nicholas J. White +40 more
Artemisinin Resistance in Plasmodium falciparum Malaria
Arjen M. Dondorp,François Nosten,Poravuth Yi,Debashish Das,Aung Phae Phyo,Joel Tarning,Khin Maung Lwin,Frédéric Ariey,Warunee Hanpithakpong,Sue J. Lee,Pascal Ringwald,Kamolrat Silamut,Mallika Imwong,Kesinee Chotivanich,Pharath Lim,Trent Herdman,Sen Sam An,Shunmay Yeung,Pratap Singhasivanon,Nicholas P. J. Day,Niklas Lindegardh,Duong Socheat,Nicholas J. White +22 more