Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial
Katherine Anagnostou,Sabita Islam,Y. King,Loraine Foley,Laura Pasea,Simon Bond,Simon Bond,Christopher R. Palmer,John Deighton,Pamela Ewan,Andrew Clark +10 more
TLDR
OIT successfully induced desensitisation in most children within the study population with peanut allergy of any severity, with a clinically meaningful increase in peanut threshold.About:
This article is published in The Lancet.The article was published on 2014-04-12 and is currently open access. It has received 359 citations till now. The article focuses on the topics: Peanut allergy & Randomized controlled trial.read more
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Journal ArticleDOI
Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management.
TL;DR: This review provides general information to serve as a primer for those embarking on understanding food allergy and also details advances and updates in epidemiology, pathogenesis, diagnosis, and treatment that have occurred over the 4 years since the last comprehensive review.
Journal ArticleDOI
AR101 Oral Immunotherapy for Peanut Allergy
Brian P. Vickery,Andrea Vereda,Thomas B. Casale,Kirsten Beyer,George Du Toit,Jonathan O'b Hourihane,Stacie M. Jones,Stacie M. Jones,Wayne G. Shreffler,Annette Marcantonio,Rezi Zawadzki,Lawrence Sher,W. Carr,Stanley Fineman,Leon Greos,Rima Rachid,M Dolores Ibáñez,Stephen A. Tilles,Amal Assa'ad,Caroline Nilsson,Ned Rupp,Michael J Welch,Gordon Sussman,Sharon Chinthrajah,Katharina Blumchen,Ellen Sher,Jonathan M. Spergel,Frederick E Leickly,Stefan Zielen,Julie Wang,Georgiana M Sanders,Robert A. Wood,Amarjit Cheema,Carsten Bindslev-Jensen,Stephanie A. Leonard,Rita Kachru,Douglas T Johnston,Frank C Hampel,Edwin H. Kim,Aikaterini Anagnostou,Jacqueline A. Pongracic,Moshe Ben-Shoshan,Hemant P Sharma,Allan Stillerman,Hugh H Windom,William H. Yang,Antonella Muraro,José Manuel Zubeldia,Vibha Sharma,Morna J. Dorsey,Hey Chong,Jason A. Ohayon,J. Andrew Bird,Tara F. Carr,Dareen Siri,Montserrat Fernandez-Rivas,David K Jeong,David Fleischer,Jay A. Lieberman,Anthony E.J. Dubois,Marina Tsoumani,Christina E. Ciaccio,Jay M. Portnoy,Lyndon E Mansfield,Stephen B Fritz,Bruce J. Lanser,Jonathan Matz,Hanneke N G Oude Elberink,Pooja Varshney,Stephen G Dilly,Daniel C. Adelman,A. Wesley Burks +71 more
TL;DR: Treatment with AR101 resulted in higher doses of peanut protein that could be ingested without dose‐limiting symptoms and in lower symptom severity during peanut exposure at the exit food challenge than placebo, in this phase 3 trial of oral immunotherapy in children and adolescents who were highly allergic to peanut.
Journal ArticleDOI
International consensus on allergy immunotherapy
Marek Jutel,Ioana Agache,Sergio Bonini,A. Wesley Burks,Moises A. Calderon,Walter Canonica,Linda Cox,Pascal Demoly,A. J. Frew,Robin O'Hehir,Jörg Kleine-Tebbe,Antonella Muraro,Gideon Lack,Désirée Larenas,Michael Levin,Harald Nelson,Ruby Pawankar,Oliver Pfaar,Ronald van Ree,Hugh A. Sampson,Alexandra F. Santos,George Du Toit,Thomas Werfel,Roy Gerth van Wijk,Luo Zhang,Cezmi A. Akdis +25 more
TL;DR: The international community of allergy specialists recognizes the need to develop a comprehensive consensus report to harmonize, disseminate, and implement the best AIT practice.
Journal ArticleDOI
Administration of a probiotic with peanut oral immunotherapy: A randomized trial
Mimi L.K. Tang,Mimi L.K. Tang,Anne-Louise Ponsonby,Francesca Orsini,Dean Tey,Dean Tey,Marnie Robinson,Marnie Robinson,Ee Lyn Su,Ee Lyn Su,Paul V. Licciardi,Wesley Burks,Susan Donath,Susan Donath +13 more
TL;DR: PPOIT was effective in inducing possible sustained unresponsiveness and immune changes that suggest modulation of the peanut-specific immune response and the relative contributions of probiotics versus OIT.
Journal ArticleDOI
EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy
Giovanni B. Pajno,Montserrat Fernandez-Rivas,Stefania Arasi,Stefania Arasi,Graham Roberts,Graham Roberts,Graham Roberts,Cezmi A. Akdis,Montserrat Alvaro-Lozano,Kirsten Beyer,Carsten Bindslev-Jensen,Wesley Burks,M. Ebisawa,Philippe Eigenmann,Edward F. Knol,Kari C. Nadeau,Lars K. Poulsen,R. van Ree,Alexandra F. Santos,Alexandra F. Santos,G. Du Toit,G. Du Toit,S. Dhami,Ulugbek Nurmatov,Y Boloh,Mika J. Mäkelä,Liam O'Mahony,Nikolaos G. Papadopoulos,Cansin Sackesen,Ioana Agache,Elizabeth Angier,Susanne Halken,Marek Jutel,Steffen Lau,Oliver Pfaar,Dermot Ryan,Gunter J. Sturm,E-M. Varga,R. G. Van Wijk,Aziz Sheikh,Antonella Muraro +40 more
TL;DR: Patients and their families should be provided with information about the use of FA‐AIT for IgE‐mediated food allergy to allow them to make an informed decision about the therapy.
References
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Long-Term Clinical Efficacy of Grass-Pollen Immunotherapy
Stephen R. Durham,Samantha Walker,Eva-Maria Varga,Mikila R. Jacobson,Fiona O’Brien,Wendy Noble,Stephen J. Till,Qutayba Hamid,Kayhan T. Nouri-Aria +8 more
TL;DR: Althoughthere was a tendency for immediate sensitivity to allergen to return late after discontinuation, there was a sustained reduction in the late skin response and associated CD3+ T-cell infiltration and interleukin-4 messenger RNA expression.
Journal ArticleDOI
Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study.
TL;DR: For example, this paper found that the prevalence of self-reported peanut and tree-nut allergy increased from 0.4% in 1997 to 0.8% in 2002 by a factor of 1.04% (95% CI, 0.9-1.24%).
Journal ArticleDOI
Clinical efficacy and immune regulation with peanut oral immunotherapy.
Stacie M. Jones,Laurent Pons,Joseph L. Roberts,Amy M. Scurlock,Tamara T. Perry,Mike Kulis,Wayne G. Shreffler,Pamela H. Steele,Karen A. Henry,Margaret Adair,James M. Francis,Stephen R. Durham,Brian P. Vickery,Xiao-Ping Zhong,A. Wesley Burks +14 more
TL;DR: Microarray data suggest a novel role for apoptosis in OIT, which induces clinical desensitization to peanut, with significant longer-term humoral and cellular changes.
Journal ArticleDOI
Allergen injection immunotherapy for seasonal allergic rhinitis
Moises A. Calderon,Bernadette Alves,Mikila R. Jacobson,Brian Hurwitz,Aziz Sheikh,Stephen R. Durham +5 more
TL;DR: This review has shown that specific allergen injection immunotherapy in suitably selected patients with seasonal allergic rhinitis results in a significant reduction in symptom scores and medication use and no long-term consequences from adverse events.