Association between regional selenium status and reported outcome of COVID-19 cases in China.
TLDR
Findings shed light on a human selenium-deficiency disease, a cardiomyopathy known as Keshan disease, named after the area in northeast China where it was endemic, which showed a seasonal variation, suggesting a viral cofactor that was later identified as coxsackievirus B3.About:
This article is published in The American Journal of Clinical Nutrition.The article was published on 2020-06-01 and is currently open access. It has received 270 citations till now. The article focuses on the topics: Keshan disease & Selenium deficiency.read more
Citations
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The COVID-19 Pandemic and Physical Activity
Jeffrey A. Woods,Noah T. Hutchinson,Scott K. Powers,William O. Roberts,Mari Carmen Gomez-Cabrera,Zsolt Radak,István Berkes,Anita Boros,Istvan Boldogh,Christiaan Leeuwenburgh,Hélio José Coelho-Júnior,Emanuele Marzetti,Ying Cheng,Jiankang Liu,J. Larry Durstine,Junzhi Sun,Li Li Ji +16 more
TL;DR: The cellular mechanisms and danger of this “second wave” effect of COVID-19 to the human body, along with the effects of aging, proper nutrition, and regular physical activity, are reviewed in this editorial article.
Journal ArticleDOI
Metallodrugs are unique: opportunities and challenges of discovery and development
Elizabeth J Anthony,Elizabeth M. Bolitho,Hannah E. Bridgewater,Oliver W. L. Carter,Jane M. Donnelly,Cinzia Imberti,Edward C Lant,Frederik Lermyte,Frederik Lermyte,Russell J. Needham,Marta Palau,Peter J. Sadler,Huayun Shi,Fang-Xin Wang,Wen-Ying Zhang,Zijin Zhang +15 more
TL;DR: In this paper, the authors focus on early-stage in vitro drug discovery, highlighting the challenges of evaluating anticancer, antimicrobial and antiviral metallo-pharmacophores in cultured cells, and identifying their targets.
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Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: Could they help against COVID-19?
Hira Shakoor,Jack Feehan,Ayesha S Al Dhaheri,Habiba I. Ali,Carine Platat,Leila Cheikh Ismail,Vasso Apostolopoulos,Lily Stojanovska,Lily Stojanovska +8 more
TL;DR: Evidence surrounding the role of these dietary components in immunity as well as their specific effect in CO VID-19 patients are discussed, and how supplementation of these nutrients may be used as therapeutic modalities potentially to decrease the morbidity and mortality rates of patients with COVID-19 is discussed.
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Selenium Deficiency Is Associated with Mortality Risk from COVID-19
Arash Moghaddam,Raban Arved Heller,Qian Sun,Julian Seelig,Asan Cherkezov,Linda Seibert,Julian Hackler,Petra Seemann,Joachim Diegmann,Maximilian Pilz,Manuel Bachmann,Waldemar B. Minich,Lutz Schomburg +12 more
TL;DR: It is concluded that Se status analysis in COVID patients provides diagnostic information and strengthens the notion of a relevant role of Se for COVID convalescence and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.
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Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19.
Jan Alexander,Alexey A. Tinkov,Alexey A. Tinkov,Tor A. Strand,Tor A. Strand,Urban Alehagen,Anatoly V. Skalny,Anatoly V. Skalny,Jan Aaseth,Jan Aaseth +9 more
TL;DR: The usefulness of early micronutrient intervention, with focus on zinc, selenium, and vitamin D, to relieve escalation of COVID-19 is explored and initiation of adequate supplementation in high-risk areas and/or soon after the time of suspected infection with SARS-CoV-2 is recommended.
References
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The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China
TL;DR: The COVID-19 epidemic has spread very quickly and only took 30 days to expand from Hubei to the rest of Mainland China, with many people returning from a long holiday, China needs to prepare for the possible rebound of the epidemic.
Journal ArticleDOI
Selenium and human health
TL;DR: The crucial factor that needs to be emphasised with regard to the health effects of selenium is the inextricable U-shaped link with status; whereas additional seenium intake may benefit people with low status, those with adequate-to-high status might be affected adversely and should not take selenum supplements.
Journal ArticleDOI
The influence of selenium on immune responses.
Peter R. Hoffmann,Marla J. Berry +1 more
TL;DR: Deciding how Se intake differentially affects various types of immune responses and dissecting the mechanisms by which this occurs will lead to a better utilization of Se-supplementation for human diseases involving the immune system.
Journal ArticleDOI
High risk of HIV-related mortality is associated with selenium deficiency
Marianna K Baum,Gail Shor-Posner,Shenghan Lai,Guoyan Zhang,Hong Lai,Mary A Fletcher,Howerde E. Sauberlich,J. B. Page +7 more
TL;DR: Results indicate that selenium deficiency is an independent predictor of survival for those with HIV-1 infection.
Journal ArticleDOI
Selenium, Selenoproteins and Viral Infection
TL;DR: The formal identification of viral selenoproteins in the genome of molluscum contagiosum and fowlpox viruses demonstrated the importance of selenocsteine in viral cycle.
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