Journal ArticleDOI
Association of Baseline Diuretic Use With Cardiovascular Outcomes in Patients With Heart Failure With Preserved Ejection Fraction: A Secondary Analysis From TOPCAT.
Sadiya S. Khan,Mark D. Huffman,Katherine M. Harrington,Abigail S. Baldridge,Jie Yu,Bruce Neal,Clare Arnott,Sanjiv J. Shah +7 more
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This article is published in Journal of Cardiac Failure.The article was published on 2021-02-24. It has received 1 citations till now. The article focuses on the topics: Heart failure with preserved ejection fraction.read more
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Journal ArticleDOI
Efficacy and safety of diuretics in heart failure with preserved ejection fraction: a scoping review.
Arushi Singh,Anubha Agarwal,Q. Eileen Wafford,Sanjiv J. Shah,Mark D. Huffman,Mark D. Huffman,Sadiya S. Khan +6 more
TL;DR: In this article, the authors conducted a scoping review to map trial data of diuretic efficacy and safety in patients with heart failure with preserved ejection fraction (HFpEF).
References
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Journal ArticleDOI
Spironolactone for Heart Failure with Preserved Ejection Fraction
Bertram Pitt,Marc A. Pfeffer,Susan F. Assmann,Robin Boineau,Inder S. Anand,Brian Claggett,Nadine Oliveira Clausell,Akshay S. Desai,Rafael Diaz,Jerome L. Fleg,Ivan Gordeev,Brian Harty,John F. Heitner,Christopher T. Kenwood,Eldrin F. Lewis,Eileen O'Meara,Jeffrey L. Probstfield,Tamaz Shaburishvili,Sanjiv J. Shah,Scott D. Solomon,Nancy K. Sweitzer,Song Yang,Sonja M. McKinlay +22 more
TL;DR: In patients with heart failure and a preserved ejection fraction, treatment with spironolactone did not significantly reduce the incidence of the primary composite outcome of death from cardiovascular causes, aborted cardiac arrest, or hospitalization for the management of heart failure.
Journal ArticleDOI
Regional Variation in Patients and Outcomes in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) Trial
Marc A. Pfeffer,Brian Claggett,Susan F. Assmann,Robin Boineau,Inder S. Anand,Nadine Oliveira Clausell,Akshay S. Desai,Rafael Diaz,Jerome L. Fleg,Ivan Gordeev,John F. Heitner,Eldrin F. Lewis,Eileen O'Meara,Jean L. Rouleau,Jeffrey L. Probstfield,Tamaz Shaburishvili,Sanjiv J. Shah,Scott D. Solomon,Nancy K. Sweitzer,Sonja M. McKinlay,Bertram Pitt +20 more
TL;DR: This post hoc analysis demonstrated greater potassium and creatinine changes and possible clinical benefits with spironolactone in patients with heart failure and preserved ejection fraction from the Americas.
Journal ArticleDOI
Empagliflozin in Heart Failure: Diuretic and Cardiorenal Effects
Matthew D. Griffin,Veena S. Rao,Juan Betuel Ivey-Miranda,James Fleming,Devin Mahoney,Christopher Maulion,Nisha Suda,Krishmita Siwakoti,Tariq Ahmad,Daniel Jacoby,Ralph Riello,Lavanya Bellumkonda,Zachary L. Cox,Sean P. Collins,Sangchoon Jeon,Jeffrey M. Turner,F. Perry Wilson,Javed Butler,Silvio E. Inzucchi,Jeffrey M. Testani +19 more
TL;DR: Empagliflozin causes significant natriuresis, particularly when combined with loop diuretics, resulting in an improvement in blood volume, and may represent a mechanism contributing to the superior long-term heart failure outcomes observed with these agents.
Journal ArticleDOI
Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial
TL;DR: In this moderately sized DR trial, weight loss was excellent with the addition of metolazone, IV chlorothiazide, or tolvaptan to loop diuretics, without a detectable between-group difference.
Journal ArticleDOI
Factors Associated With and Prognostic Implications of Cardiac Troponin Elevation in Decompensated Heart Failure With Preserved Ejection Fraction: Findings From the American Heart Association Get With The Guidelines-Heart Failure Program.
Ambarish Pandey,Harsh Golwala,Shubin Sheng,Adam D. DeVore,Adrian F. Hernandez,Deepak L. Bhatt,Paul A. Heidenreich,Clyde W. Yancy,James A. de Lemos,Gregg C. Fonarow +9 more
TL;DR: Troponin elevation among patients with acutely decompensated HFpEF is associated with worse in-hospital and postdischarge outcomes, independent of other predictive variables.
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Cardiac Structure and Function and Prognosis in Heart Failure With Preserved Ejection Fraction
Amil M. Shah,Brian Claggett,Nancy K. Sweitzer,Sanjiv J. Shah,Inder S. Anand,Eileen O'Meara,Akshay S. Desai,John F. Heitner,Guichu Li,James C. Fang,Jean L. Rouleau,Michael R. Zile,Markov Va,Vyacheslav Ryabov,Gilmar Reis,Susan F. Assmann,Sonja M. McKinlay,Bertram Pitt,Marc A. Pfeffer,Scott D. Solomon +19 more