Journal ArticleDOI
Asthma: An Undermined State of Immunodeficiency.
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TLDR
This review summarizes the common pathophysiological background of asthma and infections, highlighting the importance of an underlying immune system defect that predispose individuals to recurrent infections and asthma.Abstract:
Asthma is a heterogeneous chronic respiratory disease characterized by an increased burden of infections. Respiratory tract infections associated with an increased risk for asthma especially when occurring in the first months of life, also represent the most common cause of asthma exacerbations. The association between asthma and the increased frequency of infections and microbiota dysbiosis might be explained by a common mechanism, such as an underlying immune system defect. Apart from the well-established association between primary immunodeficiencies and asthma, several alterations in the immune response following infection have also been observed in asthmatic patients. An impairment in lung epithelial barrier integrity exists and is associated with both an increased susceptibility to infections and the development of asthma. Asthmatic patients are also found to have a deficient interferon (IFN) response upon infection. Additionally, defects in Toll-like receptor (TLR) signaling are observed in asthma and are correlated with both recurrent infections and asthma development. In this review, we summarize the common pathophysiological background of asthma and infections, highlighting the importance of an underlying immune system defect that predispose individuals to recurrent infections and asthma.read more
Citations
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Journal ArticleDOI
Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma
Oxana Yu. Kytikova,Juliy M. Perelman,Tatyana P. Novgorodtseva,Yulia K. Denisenko,Viktor P. Kolosov,Marina V. Antonyuk,Tatyana A. Gvozdenko +6 more
TL;DR: This review summarizes current views on the structure and function of PPARs, as well as their participation in the pathogenesis of chronic inflammation in asthma.
Journal ArticleDOI
Therapeutic potential of sulfur-containing natural products in inflammatory diseases
Xu Cao,Lei Cao,Wencan Zhang,Rongzhu Lu,Jin-Song Bian,Jin-Song Bian,Xiao-Wei Nie,Xiao-Wei Nie +7 more
TL;DR: The aim of this review was to survey the emerging evidence on role of sulfur-containing NPs, such as glutathione, garlic-derived sulfur compounds, Epipolythiodioxopiperazines (EPTs), Isothiocyanates (ITCs), and Ergothioneine (EGT), in the control of inflammation and to determine the possible underlying mechanisms.
Journal ArticleDOI
TLR4 polymorphisms as potential predictors of atopic dermatitis in Chinese Han children
TL;DR: The relationship between TLR4 gene polymorphisms and the susceptibility or severity of AD among Chinese Han children is evaluated.
Journal ArticleDOI
The role of lipids in the signaling mechanisms of toll-like receptors
O. Yu. Kytikovа,Tatyana P. Novgorodtseva,Yu. K. Denisenko,Marina V. Antonyuk,Tatyana A. Gvozdenko +4 more
TL;DR: The mechanisms by which SFAs, PUFAs, and Ox-PLs modulate TLRs activation in lipid rafts will contribute to the development of a strategy to reduce the risk of chronic diseases caused by inflammatory reactions mediated by TLRs.
Journal ArticleDOI
Inborn errors of immunity and related microbiome
Raja Hazime,Fatima-ezzohra Eddehbi,Saad El Mojadili,Nadia Lakhouaja,Ikram Souli,Abdel Al-Raheem Salami,Bouchra M’Raouni,Imane Brahim,Mohamed Oujidi,Morad Guennouni,Ahmed Aziz Bousfiha,B. Admou +11 more
TL;DR: A promising strategy is to develop optimized prebiotic, probiotics, postbiotics, and fecal microbial transplantation to rebalance the intestinal microbiota and thereby attenuate the disease activity of many IEIs.
References
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Journal ArticleDOI
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Journal ArticleDOI
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