B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
Vijay K. Kuchroo,Mercy Prabhu Das,Julia A. Brown,Ann M. Ranger,Scott S. Zamvil,Raymond A. Sobel,Howard L. Weiner,Nasrin Nabavi,Laurie H. Glimcher +8 more
TLDR
Interaction of B 7-1 and B7-2 with shared counterreceptors CD28 and CTLA-4 results in very different outcomes in clinical disease by influencing commitment of precursors to a Th1 or Th2 lineage.About:
This article is published in Cell.The article was published on 1995-03-10 and is currently open access. It has received 1766 citations till now. The article focuses on the topics: Cytokine secretion & T cell.read more
Citations
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Immunobiology of Dendritic Cells
Jacques Banchereau,Francine Brière,Christophe Caux,Jean Davoust,Serge Lebecque,Yong-Jun Liu,Bali Pulendran,Karolina Palucka +7 more
TL;DR: Dendritic cells are antigen-presenting cells with a unique ability to induce primary immune responses and may be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response.
Journal ArticleDOI
Functional diversity of helper T lymphocytes.
TL;DR: The existence of subsets of CD4+ helper T lymphocytes that differ in their cytokine secretion patterns and effector functions provides a framework for understanding the heterogeneity of normal and pathological immune responses.
Journal ArticleDOI
Cellular responses to interferon-gamma.
TL;DR: Much of the cellular response to IFN-gamma can be described in terms of a set of integrated molecular programs underlying well-defined physiological systems, for example the induction of efficient antigen processing for MHC-mediated antigen presentation, which play clearly defined roles in pathogen resistance.
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Cd28/b7 system of t cell costimulation
TL;DR: This review summarizes the state of CD28/B7 immunobiology both in vitro and in vivo; summarizes the many experiments that have led to the current understanding of the participants in this complex receptor/ligand system; and illustrates the current models for CD28-mediated T cell and B cell regulation.
Journal ArticleDOI
The instructive role of innate immunity in the acquired immune response.
TL;DR: Innate immunity has been considered only to provide rapid, incomplete antimicrobial host defense until the slower, more definitive acquired immune response develops but may have an additional role in determining which antigens the acquired immune system responds to and the nature of that response.
References
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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more
TL;DR: Two types of cloned helper T cells are described, defined primarily by differences in the pattern of lymphokines ynthesized, and the different functions of the two types of cells and their lymphokine synthesis are discussed.
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CTLA-4 can function as a negative regulator of T cell activation
Theresa L. Walunas,Deborah J. Lenschow,Christina Y. Bakker,Peter S. Linsley,Gordon J. Freeman,Jonathan Green,Craig B. Thompson,Craig B. Thompson,Jeffrey A. Bluestone +8 more
TL;DR: Results suggest that the MAb may obstruct the interaction of CTLA-4 with its natural ligand and block a negative signal, or directly signal T cells to down-regulate immune function.
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Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis
TL;DR: Mucosally derived TH2-like clones induced by oral antigen can actively regulate immune responses in vivo and may represent a different subset of T cells.
Journal ArticleDOI
CTLA-4 is a second receptor for the B cell activation antigen B7.
Peter S. Linsley,William E. Brady,Mark Urnes,Laura Sue Grosmaire,Nitin K. Damle,Jeffrey A. Ledbetter +5 more
TL;DR: These findings provide direct evidence that, like its structural homologue CD28, CTLA- 4 is able to bind the B7 counter-receptor on activated B cells.
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TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties.
Tim R. Mosmann,R L Coffman +1 more