Binding and Degradation of Low Density Lipoproteins by Cultured Human Fibroblasts COMPARISON OF CELLS FROM A NORMAL SUBJECT AND FROM A PATIENT WITH HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA
TLDR
It is raised that a prerequisite for the regulation of cholestero-genesis in cultured fibroblasts is the initial binding of low density lipoproteins to the high affinity surface receptor sites and that a defect in this process represents the primary genetic abnormality in the disorder familial hypercholesterolemia.About:
This article is published in Journal of Biological Chemistry.The article was published on 1974-08-25 and is currently open access. It has received 1421 citations till now. The article focuses on the topics: Low-density lipoprotein receptor activity & Lipoprotein.read more
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Journal ArticleDOI
A receptor-mediated pathway for cholesterol homeostasis.
TL;DR: The approach was to apply the techniques of cell culture to unravel the postulated regulatory defect in FH, which led to the discovery of a cell surface receptor for a plasma cholesterol transport protein called low density lipoprotein (LDL) and to the elucidation of the mechanism by which this receptor mediates feedback control of cholesterol synthesis.
Journal ArticleDOI
The pathogenesis of atherosclerosis (first of two parts).
Russell Ross,John A. Glomset +1 more
Journal ArticleDOI
Coated pits, coated vesicles, and receptor-mediated endocytosis
TL;DR: It is now recognised that receptor-mediated endocytosis has a fundamental role in the growth, nutrition and differentiation of animal cells.
Journal ArticleDOI
Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ
Laszlo Nagy,Laszlo Nagy,Peter Tontonoz,Peter Tontonoz,Jacqueline G.A Alvarez,Hongwu Chen,Ronald M. Evans,Ronald M. Evans +7 more
TL;DR: The data suggest that the biologic effects of oxLDL are coordinated by two sets of receptors, one on the cell surface, which binds and internalizes the particle, and one in the nucleus, which is transcriptionally activated by its component lipids.
Book ChapterDOI
Receptor-mediated endocytosis of low-density lipoprotein in cultured cells
TL;DR: Study of the cell surface binding, internalization, and metabolism of low-density lipoprotein (LDL) in cultured cells have provided useful information regarding the general aspects of receptor-mediated endocytosis and three classes of mutant alleles at the LDL receptor locus have been deduced.
References
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The metabolism of very low density lipoprotein proteins. I. Preliminary in vitro and in vivo observations.
TL;DR: During the first 24 h after injection of 125I-labeled very low density lipoprotein to humans, the decay rate of low densitylipoprotein apoprotein from very lowdensity lipoproteins was faster than that of apolipoprotein glutamic acid, apoipoprotein alanine1 and apolipropoteinAlanine2.