Journal ArticleDOI
Bioactive metabolites from Phoma species, an endophytic fungus from the Chinese medicinal plant Arisaema erubescens
Li-Wei Wang,Li-Wei Wang,Bai-Ge Xu,Jiaying Wang,Zhen-Zhu Su,Fu-Cheng Lin,Chu-Long Zhang,Christian P. Kubicek +7 more
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TLDR
Endophytic Phoma are promising sources of natural bioactive and novel metabolites, as well as in vitro antitumor activities against HT-29, SMMC-772, MCF-7, HL-60, MGC80-3, and P388 cell lines are concluded.Abstract:
Through bioassay-guided fractionation, the EtOAc extract of a culture broth of the endophytic fungus Phoma species ZJWCF006 in Arisaema erubescens afforded a new α-tetralone derivative, (3S)-3,6,7-trihydroxy-α-tetralone (1), together with cercosporamide (2), β-sitosterol (3), and trichodermin (4). The structures of compounds were established on the basis of spectroscopic analyses. Compounds 1, 2, and 3 were obtained from Phoma species for the first time. Additionally, the compounds were subjected to bioactivity assays, including antimicrobial activity, against four plant pathogenic fungi (Fusarium oxysporium, Rhizoctonia solani, Colletotrichum gloeosporioides, and Magnaporthe oryzae) and two plant pathogenic bacteria (Xanthomonas campestris and Xanthomonas oryzae), as well as in vitro antitumor activities against HT-29, SMMC-772, MCF-7, HL-60, MGC80-3, and P388 cell lines. Compound 1 showed growth inhibition against F. oxysporium and R. solani with EC50 values of 413.22 and 48.5 μg/mL, respectively. Additionally, compound 1 showed no cytotoxicity, whereas compound 2 exhibited cytotoxic activity against the six tumor cell lines tested, with IC50 values of 9.3 ± 2.8, 27.87 ± 1.78, 48.79 ± 2.56, 37.57 ± 1.65, 27.83 ± 0.48, and 30.37 ± 0.28 μM, respectively. We conclude that endophytic Phoma are promising sources of natural bioactive and novel metabolites.read more
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Journal ArticleDOI
Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites
TL;DR: The review reveals the importance of endophytic fungi from medicinal plants as a source of bioactive and chemically novel compounds for use in the pharmaceutical and agrochemical industries.
Book ChapterDOI
Endophytic Fungi: Biodiversity, Ecological Significance, and Potential Industrial Applications
Kusam Lata Rana,Divjot Kour,Imran Sheikh,Anu Dhiman,Neelam Yadav,Ajar Nath Yadav,Ali Asghar Rastegari,Karan Singh,Anil Kumar Saxena +8 more
TL;DR: This chapter critically review the production of a wide range of secondary metabolites, bioactive compounds from fungal endophytes that are a potential alternative source of secondary plant metabolites and natural producers of high-demand drugs.
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Endophytes and associated marine derived fungi—ecological and chemical perspectives
TL;DR: New insights into fungal-host interaction, chemical communication, and chemo-ecological roles of fungal metabolites, as well as new strategies for bioprospecting are presented.
Journal ArticleDOI
Bioactive secondary metabolites from Nigrospora sp. LLGLM003, an endophytic fungus of the medicinal plant Moringa oleifera Lam.
TL;DR: In vitro antifungal assay showed that griseofulvin displayed clear inhibition of the growth of 8 plant pathogenic fungi, which is the first report of the isolation of endophytic Nigrospora from M. oleifera.
Journal ArticleDOI
Jasmonic acid is involved in the signaling pathway for fungal endophyte-induced volatile oil accumulation of Atractylodes lancea plantlets.
Cheng-Gang Ren,Chuan-Chao Dai +1 more
TL;DR: Jasmonic acid acts as a downstream signaling molecule in NO- and H2O2-mediated volatile oil accumulation induced by endophytic fungus and has a complementary interaction with the SA signaling pathway.
References
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Journal ArticleDOI
Natural Products as Sources of New Drugs over the Last 25 Years
David J. Newman,Gordon M. Cragg +1 more
TL;DR: This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003 and is able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame.
Journal ArticleDOI
Bioprospecting for Microbial Endophytes and Their Natural Products
Gary A. Strobel,Bryn Daisy +1 more
TL;DR: Endophytic microorganisms reside in the living tissues of the host plant and do so in a variety of relationships, ranging from symbiotic to slightly pathogenic, which may produce a plethora of substances of potential use to modern medicine, agriculture, and industry.
Journal ArticleDOI
Two divergent intragenomic rDNA ITS2 types within a monophyletic lineage of the fungus Fusarium are nonorthologous
TL;DR: The results suggest that the ancestral ITS2 types may have arisen following an ancient interspecific hybridization or gene duplication which occurred prior to the evolutionary radiation of the Gibberella fujikuroi complex and related species of Fusarium.
Journal ArticleDOI
Natural products from endophytic microorganisms.
TL;DR: The prospects of finding new drugs that may be effective candidates for treating newly developing diseases in humans, plants, and animals are great and other applications in industry and agriculture may also be discovered among the novel products produced by endophytic microbes.
Journal ArticleDOI
Highlights of the Didymellaceae: A polyphasic approach to characterise Phoma and related pleosporalean genera
TL;DR: The phylogenetic analysis revealed that the current Boeremaean subdivision is incorrect from an evolutionary point of view, revealing the genus Phoma to be highly polyphyletic.
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