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Biodegradable and electrically conducting polymers for biomedical applications

TLDR
Conducting polymers have been widely used in biomedical applications such as biosensors and tissue engineering but their non-degradability still poses a limitation.
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This article is published in Progress in Polymer Science.The article was published on 2013-09-01. It has received 498 citations till now.

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Conductive polymers: towards a smart biomaterial for tissue engineering.

TL;DR: Focusing mainly on polypyrrole, polyaniline and poly(3,4-ethylenedioxythiophene), this work reviews conductive polymers from the perspective of tissue engineering.
Journal ArticleDOI

Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

TL;DR: The antibacterial electroactive injectable hydrogel dressing prolonged the lifespan of dressing relying on self-healing ability and significantly promoted the in vivo wound healing process attributed to its multifunctional properties, meaning that they are excellent candidates for full-thickness skin wound healing.
Journal ArticleDOI

Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.

TL;DR: In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model.
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Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing

TL;DR: These adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide using a H2 O2 /HPR (horseradish peroxidase) system are prepared for wound dressing and are an excellent wound dressing for full-thickness skin repair.
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Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing.

TL;DR: The authors report on the development of injectable, biocompatible carbon nanotube reinforced quaternized chitosan cryogels with shape memory, conductivity and antibacterial properties for hemostatic control for lethal noncompressible hemorrhage hemostasis and wound healing.
References
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Journal ArticleDOI

Tuning the release rate of acidic degradation products through macromolecular design of caprolactone-based copolymers.

TL;DR: The results show that the release rate of acidic degradation products, a possible cause of acidic microclimates and inflammatory responses, is controllable through macromolecular design, i.e., different distribution of the weak linkages in the copolymers.
Journal ArticleDOI

Electroactive porous tubular scaffolds with degradability and non-cytotoxicity for neural tissue regeneration.

TL;DR: The scaffolds were subjected to the WST test (a cell proliferation and cytotoxicity assay using water-soluble tetrazolium salts) with HaCaT keratinocyte cells, and the results show that these scaffolds are non-cytotoxic.
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High-strength pristine porous chitosan scaffolds for tissue engineering

TL;DR: The ability to produce high-strength chitosan scaffolds and engineer their mechanical properties can substantially expand the applicability of chitOSan in tissue engineering as well as other engineering applications.
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Bioelectrochemical control of neural cell development on conducting polymers.

TL;DR: Combinations of electrochemical and molecule self-assembling methods are described to consistently control neural cell development on PEDOT:PSS while maintaining very low interfacial impedance, thus improving cell/electrode communication in prosthetic devices and providing a platform for tissue repair strategies.
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Electrical stimulation enhances viability of human cutaneous fibroblasts on conductive biodegradable substrates.

TL;DR: Electrically conductive biodegradable polymer membranes were prepared by mixing conductive polypyrrole particles with poly(L-lactic acid) solution followed by solution casting and solvent evaporation and supported the adhesion and proliferation of the fibroblasts in both the presence and absence of ES.
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