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Biodegradable and electrically conducting polymers for biomedical applications

TLDR
Conducting polymers have been widely used in biomedical applications such as biosensors and tissue engineering but their non-degradability still poses a limitation.
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This article is published in Progress in Polymer Science.The article was published on 2013-09-01. It has received 498 citations till now.

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Conductive polymers: towards a smart biomaterial for tissue engineering.

TL;DR: Focusing mainly on polypyrrole, polyaniline and poly(3,4-ethylenedioxythiophene), this work reviews conductive polymers from the perspective of tissue engineering.
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Antibacterial anti-oxidant electroactive injectable hydrogel as self-healing wound dressing with hemostasis and adhesiveness for cutaneous wound healing

TL;DR: The antibacterial electroactive injectable hydrogel dressing prolonged the lifespan of dressing relying on self-healing ability and significantly promoted the in vivo wound healing process attributed to its multifunctional properties, meaning that they are excellent candidates for full-thickness skin wound healing.
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Antibacterial adhesive injectable hydrogels with rapid self-healing, extensibility and compressibility as wound dressing for joints skin wound healing.

TL;DR: In vivo experiments indicated that curcumin loaded hydrogels significantly accelerated wound healing rate with higher granulation tissue thickness and collagen disposition and upregulated vascular endothelial growth factor (VEGF) in a full-thickness skin defect model.
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Adhesive Hemostatic Conducting Injectable Composite Hydrogels with Sustained Drug Release and Photothermal Antibacterial Activity to Promote Full-Thickness Skin Regeneration During Wound Healing

TL;DR: These adhesive hemostatic antioxidant conductive photothermal antibacterial hydrogels based on hyaluronic acid-graft-dopamine and reduced graphene oxide using a H2 O2 /HPR (horseradish peroxidase) system are prepared for wound dressing and are an excellent wound dressing for full-thickness skin repair.
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Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing.

TL;DR: The authors report on the development of injectable, biocompatible carbon nanotube reinforced quaternized chitosan cryogels with shape memory, conductivity and antibacterial properties for hemostatic control for lethal noncompressible hemorrhage hemostasis and wound healing.
References
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Journal ArticleDOI

Synthesis of Water Soluble, Biodegradable, and Electroactive Polysaccharide Crosslinker with Aldehyde and Carboxylic Groups for Biomedical Applications

TL;DR: The synthesis and characterization of a polysaccharide crosslinker of tetraaniline grafting oxidized sodium alginate with large aldehyde and carboxylic groups is reported.
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Simple Route to Size-Tunable Degradable and Electroactive Nanoparticles from the Self-Assembly of Conducting Coil–Rod–Coil Triblock Copolymers

TL;DR: In this article, a series of coil-rod-coil triblock copolymers consisting of a middle aniline pentamer (AP) segment and two polycaprolactone (PCL) segments were easily synthesized by a combination of a ring-opening polymerization of CL initiated by an anileine dimer (AD) giving AD-PCL and an oxidative coupling reaction between the AD and p-phenylenediamine.
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Synthesis and Surface Morphology of Tetraaniline‐block‐Poly(L‐lactate) Diblock Oligomers

TL;DR: In this paper, Tetraaniline block poly(L-lactide) diblock oligomers are synthesized via ring-opening polymerization and two different surface morphologies are discussed in detail.
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Biodegradable free-standing nanomembranes of conducting polymer:polyester blends as bioactive platforms for tissue engineering

TL;DR: Interestingly, adhesion and proliferation assays with epithelial cells revealed that the behavior of the blend as cellular matrix is superior to that of the two individual polymers, validating the use of the nanomembranes as bioactive substrates for tissue regeneration.
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Synthesis and characterization of soluble polypyrrole–poly(ɛ-caprolactone) polymer blends with improved electrical conductivities

TL;DR: In this paper, the composition and structural characteristics of polypyrrole-poly(−)-caprolactone (PPy-PCL) blends were determined by Fourier transform infrared, ultraviolet-visible, and X-ray photoelectron spectroscopic methods.
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