Journal ArticleDOI
Biopolymer zein-coated gold nanoparticles: Synthesis, antibacterial potential, toxicity and histopathological effects against the Zika virus vector Aedes aegypti
Periyakaruppan Suganya,Baskaralingam Vaseeharan,Sekar Vijayakumar,Banumathi Balan,Marimuthu Govindarajan,Naiyf S. Alharbi,Shine Kadaikunnan,Jamal M. Khaled,Giovanni Benelli +8 more
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TLDR
The study concludes that Ze-AuNPs have excellent antibacterial, antibiofilm effects and has ability to control the larval populations of A. aegypti mosquitoes.Abstract:
The control of multidrug-resistant bacteria as well as insect pests and vectors is timely and important now a days. The present study was designed to evaluate the in vitro antibacterial, antibiofilm and mosquito larvicidal effects of gold nanoparticles synthesized using the zein biopolymer (Ze-AuNPs) against Gram positive (Bacillus pumilus and Bacillus subtilis), Gram negative (Shigella sonnei and Pseudomonas aeruginosa) bacteria and third instar larvae of the dengue and Zika virus vector Aedes aegypti. The synthesized Ze-AuNPs were characterized by UV-vis spectroscopy, X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). The antibacterial assays testing Ze-AuNPs at 100μg/ml showed that the zones of inhibition against Gram positive species B. pumilus and B. subtilis were 13.9 and 14.2mm, respectively, while for Gram negative S. sonnei and P. aeruginosa they were 18.1 and 18.4mm, respectively. Light and confocal laser scanning microscopy (CLSM) confirmed the interruption and disintegration of bacterial biofilm post-treatment with Ze-AuNPs at 100μg/ml. In larvicidal assays on A. aegypti, HAuCl4 and Ze-AuNPs treated third instar larvae of A. aegypti showed LC50 of 26.6 and 6.81mg/L, respectively, and LC90 of 81.1 and 13.6mg/L respectively. The histopathological analysis of A. aegypti treated with Ze-AuNPs showed complete disintegration of abdominal region, particularly the midgut and caeca, with loss of lateral and caudal hairs. The stereomicroscopic visualization of A. aegypti treated with Ze-AuNPs showed the loss of upper head hair, lower head hair, antenna hair, lateral hair and caudal hair. Overall, the study concludes that Ze-AuNPs have excellent antibacterial, antibiofilm effects and has ability to control the larval populations of A. aegypti mosquitoes.read more
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Metal‐Based Nanomaterials in Biomedical Applications: Antimicrobial Activity and Cytotoxicity Aspects
Pooyan Makvandi,Pooyan Makvandi,Pooyan Makvandi,Chen yu Wang,Ehsan Nazarzadeh Zare,Assunta Borzacchiello,Li Na Niu,Li Na Niu,Franklin R. Tay +8 more
TL;DR: An overview on the state‐of‐the‐art antimicrobial nanosized metal‐based compounds is provided, including metal and metal oxide nanoparticles as well as transition metal nanosheets, and their biomedical applications such as catheters, implants, medical delivery systems, tissue engineering, and dentistry.
Journal ArticleDOI
Mode of action of nanoparticles against insects
TL;DR: Insect nanotoxicology research trends are critically discussed, outlining major challenges to predict the ecotoxicological consequences arising from the real-world use of nanoparticles as pesticides.
Journal ArticleDOI
Bacterial exopolysaccharide (EPS)-coated ZnO nanoparticles showed high antibiofilm activity and larvicidal toxicity against malaria and Zika virus vectors.
Muthukumar Abinaya,Baskaralingam Vaseeharan,Mani Divya,Aruna Sharmili,Marimuthu Govindarajan,Naiyf S. Alharbi,Shine Kadaikunnan,Jamal M. Khaled,Giovanni Benelli +8 more
TL;DR: The multipurpose properties of EPS-ZnO NPs revealed in the present study can be further considered for pharmaceutical, parasitological and entomological applications.
Journal ArticleDOI
Gold nanoparticles fabrication by plant extracts: synthesis, characterization, degradation of 4-nitrophenol from industrial wastewater, and insecticidal activity – A review
Maryam Teimouri,Fariba Khosravi-Nejad,Farnoosh Attar,Ali Akbar Saboury,Irena Kostova,Giovanni Benelli,Giovanni Benelli,Mojtaba Falahati +7 more
TL;DR: In this article, the potential of green synthesized AuNPs for removal of 4-nitrophenol (4NP) in industrial wastewater and insecticidal agents is discussed, shedding light on their mechanisms of action and the related non-target effects.
Journal ArticleDOI
Gold nanoparticles – against parasites and insect vectors
TL;DR: The information available on the antiparasitic role of Au NPs in the fight against malaria, leishmaniosis, toxoplasmosis, trypanosomiasis, cryptosporidiosis, and microsporidian parasites affecting human and animals health is summarized.
References
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