Journal ArticleDOI
Bioprocessing strategies to improve heterologous protein production in filamentous fungal fermentations
TLDR
An overview of the potential bioprocessing strategies that can be applied to inhibit protease activity thereby enhancing heterologous protein production is provided.About:
This article is published in Biotechnology Advances.The article was published on 2005-03-01. It has received 152 citations till now. The article focuses on the topics: Heterologous & Protease.read more
Citations
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Journal ArticleDOI
Role and significance of beta-glucosidases in the hydrolysis of cellulose for bioethanol production.
TL;DR: This article presents beta-glucosidase as the key component for bioethanol from biomass through enzymatic route along with its production strategies and general properties.
Journal ArticleDOI
Protein folding and conformational stress in microbial cells producing recombinant proteins: a host comparative overview
Brigitte Gasser,Markku Saloheimo,Ursula Rinas,Martin Dragosits,Escarlata Rodríguez-Carmona,Kristin Baumann,Maria Giuliani,Ermenegilda Parrilli,Paola Branduardi,Christine Lang,Danilo Porro,Pau Ferrer,Maria Luisa Tutino,Diethard Mattanovich,Antonio Villaverde +14 more
TL;DR: In this article, the main cellular players of this complex process are described for the most important cell factories used for biotechnological purposes, and the characterization of such adverse conditions and the elicited cell responses have permitted to better understand the physiology and molecular biology of conformational stress.
Journal ArticleDOI
Developing Aspergillus as a host for heterologous expression
TL;DR: History of the development of Aspergillus as an expression host, current state of the art and future directions are reviewed, touching on related research in other fungi when discussing the areas of greatest potential for future biotechnological applications.
Journal ArticleDOI
Plant-derived bioactive compounds produced by endophytic fungi.
TL;DR: This review mainly deals with the research progress on endophytic fungi for producing plant-derived bioactive compounds such as paclitaxel, podophyllotoxin, camptothecine, vinblastine, hypericin, and diosgenin.
Journal Article
Microbiology and Industrial Biotechnology of Food-Grade Proteases: A Perspective
TL;DR: This review tracks the developments in the field of acidic and neutral protease production with regard to the producers, methods of production and their improvement, the product and its applications.
References
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Book
Bioprocess Engineering: Basic Concepts
TL;DR: The author explains how the biotechnology and bioprocess engineering profession has changed in the modern era, and some examples of this change can be found in the chapters on Bioreactors for Suspension and Immobilized Cultures.
Journal ArticleDOI
Filamentous fungi as cell factories for heterologous protein production
Peter J. Punt,Nick van Biezen,Ana Conesa,Alwin Albers,Jeroen Mangnus,Cees A. M. J. J. van den Hondel +5 more
TL;DR: This review of current practice reveals that molecular tools have enabled several new developments but it has been process development that has driven the final breakthrough to achieving commercially relevant quantities of protein.
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Poly(vinyl alcohol) cryogels employed as matrices for cell immobilization. 3. Overview of recent research and developments
Vladimir I. Lozinsky,F.M. Plieva +1 more
TL;DR: By cell entrapment within PVA cryogel matrices, diverse immobilized biocatalysts were prepared which were capable of performing both a simple monoenzyme biotransformation of respective substrates and a complex biosynthesis of various high- and low-molecular-weight products, decompose pollutants, and operate in biosensors.
Journal ArticleDOI
The growth of molds in the form of pellets–a literature review
B. Metz,N. W. F. Kossen +1 more