Journal ArticleDOI
Blood pressure and not uraemia is the major determinant of arterial stiffness and endothelial dysfunction in patients with chronic kidney disease and minimal co-morbidity
Pajaree Lilitkarntakul,Neeraj Dhaun,Vanessa Melville,Scott Blackwell,Dinesh Talwar,Barbara Liebman,Takae Asai,Jennifer S. Pollock,Jane Goddard,David J. Webb +9 more
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TLDR
It is suggested that declining renal function, in the absence of significant co-morbidity, is associated with progressive arterial stiffness, but only patients close to dialysis exhibit endothelial dysfunction, in this non-comorbid cohort.About:
This article is published in Atherosclerosis.The article was published on 2011-05-01. It has received 73 citations till now. The article focuses on the topics: Kidney disease & Arterial stiffness.read more
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Arterial stiffness and pulse pressure in CKD and ESRD
Marie Briet,Marie Briet,Pierre Boutouyrie,Pierre Boutouyrie,Stéphane Laurent,Stéphane Laurent,Gérard M. London +6 more
TL;DR: Premature vascular aging and arterial stiffening are observed with progression of chronic kidney disease and in end-stage renal disease and this accelerated aging is associated with outward remodeling of large vessels, characterized by increased arterial radius not totally compensated for by artery wall hypertrophy.
Journal ArticleDOI
Endothelin and endothelin antagonists in chronic kidney disease
Donald E. Kohan,Matthias Barton +1 more
TL;DR: The role of ET in CKD pathogenesis is summarized and the potential therapeutic benefit of targeting the ET system in CKd is discussed, with attention to the risks and benefits of such an approach.
Journal ArticleDOI
Arterial disease in chronic kidney disease
TL;DR: End stage renal disease is associated with a very high risk of premature cardiovascular death and morbidity and recent work has highlighted the importance of aldosterone and disordered bone mineral metabolism.
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Endothelial dysfunction and cardiovascular disease in early-stage chronic kidney disease: Cause or association?
William E. Moody,Nicola C. Edwards,Melanie Madhani,Colin D. Chue,Richard P. Steeds,Charles J. Ferro,Jonathan N. Townend +6 more
TL;DR: Examining changes in endothelial function in living kidney donors before and after nephrectomy might be gained into the pathophysiology of CVD in CKD and help determine whether targeting ED or the renal disease itself has the potential to reduce CV risk.
Journal ArticleDOI
Pulmonary hypertension in patients with chronic and end-stage kidney disease
TL;DR: The pathogenesis of pulmonary hypertension in this population is due to alterations in endothelial function, increased cardiac output, and myocardial dysfunction leading to elevated left heart filling pressure, with recent data suggesting that left heart dysfunction may account for the vast majority ofmonary hypertension in patients with kidney disease.
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K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification
Andrew S. Levey,Josef Coresh,Kline Bolton,Bruce Culleton,Kathy Schiro Harvey,T. Alp Ikizler,Cynda Ann Johnson,Annamaria T. Kausz,Paul L. Kimmel,John W. Kusek,Adeera Levin,Kenneth L. Minaker,Robert Nelson,Helmut G. Rennke,Michael Steffes,Beth Witten,Ronald J. Hogg,Susan Furth,Kevin V. Lemley,Ronald J. Portman,George Schwartz,Joseph Lau,Ethan M Balk,Ronald D. Perrone,Tauqeer Karim,Lara Rayan,Inas Al-Massry,Priscilla Chew,Brad C. Astor,Deirdre De Vine,Garabed Eknoyan,Nathan W. Levin,Sally Burrows-Hudson,William F. Keane,Alan S. Kliger,Derrick Latos,Donna Mapes,Edith Oberley,Kerry Willis,George R. Bailie,Gavin J. Becker,Jerrilynn Burrowes,David Churchill,Allan J. Collins,William Couser,Dick DeZeeuw,Alan Garber,Thomas Golper,Frank A. Gotch,Antonio M. Gotto,Joel W. Greer,Richard H. Grimm,Ramon G. Hannah,Jaime Herrera Acosta,Ronald J. Hogg,Lawrence G. Hunsicker,Michael J. Klag,Saulo Klahr,Caya Lewis,Edmund G. Lowrie,Arthur J. Matas,Sally McCulloch,Maureen Michael,Joseph V. Nally,John M. Newmann,Allen R. Nissenson,Keith Norris,William F. Owen,Thakor G. Patel,Glenda Payne,Rosa A. Rivera-Mizzoni,David A. Smith,Robert A. Star,Theodore Steinman,Fernando Valderrábano,John Walls,Jean Pierre Wauters,Nanette Wenger,Josephine P. Briggs +78 more
TL;DR: In the early 1990s, the National Kidney Foundation (K/DOQI) developed a set of clinical practice guidelines to define chronic kidney disease and to classify stages in the progression of kidney disease.
Journal ArticleDOI
Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force
Mary C. Corretti,Todd J. Anderson,Emelia J. Benjamin,David S. Celermajer,Francois Charbonneau,Mark A. Creager,John E. Deanfield,Helmut Drexler,Marie Gerhard-Herman,David M. Herrington,Patrick Vallance,Joseph A. Vita,Robert A. Vogel +12 more
TL;DR: State-of-the-art information is presented and insights are provided into the strengths and limitations of high-resolution ultrasonography of the brachial artery to evaluate vasomotor function, with guidelines for its research application in the study of endothelial physiology.
Journal ArticleDOI
Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention.
Mark J. Sarnak,Andrew S. Levey,Anton C. Schoolwerth,Josef Coresh,Bruce F. Culleton,L. Lee Hamm,Peter A. McCullough,Bertram L. Kasiske,Ellie Kelepouris,Michael J. Klag,Patrick S. Parfrey,Marc A. Pfeffer,Leopoldo Raij,David J. Spinosa,Peter W.F. Wilson +14 more
TL;DR: There was a high prevalence of CVD in CKD and that mortality due to CVD was 10 to 30 times higher in dialysis patients than in the general population, and the task force recommended that patients with CKD be considered in the “highest risk group” for subsequent CVD events.
Journal ArticleDOI
Clinical epidemiology of cardiovascular disease in chronic renal disease.
Journal ArticleDOI
Impact of Aortic Stiffness on Survival in End-Stage Renal Disease
Jacques Blacher,Alain P. Guerin,Bruno Pannier,Sylvain J. Marchais,Michel E. Safar,Gérard M. London +5 more
TL;DR: These results provide the first direct evidence that in patients with ESRD, increased aortic stiffness determined by measurement of aorta pulse-wave velocity is a strong independent predictor of all-cause and mainly cardiovascular mortality.