Journal ArticleDOI
Bone marrow accessory cells regulate human bone precursor cell development.
Peter G. Eipers,Sujata Kale,Russell S. Taichman,George G. Pipia,Nancy A. Swords,Kenneth G. Mann,Michael W. Long +6 more
TLDR
Human bone marrow contains a population of OACs that are an obligate requirement for the early phases of bone cell development ex vivo, and feeder-layer studies demonstrate that these osteopoietic accessory cells do not require cell-cell interaction to promote bone precursor cell development but, rather, produce soluble molecules responsible for their effects.About:
This article is published in Experimental Hematology.The article was published on 2000-07-01. It has received 37 citations till now. The article focuses on the topics: Bone cell & Bone marrow.read more
Citations
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Journal ArticleDOI
Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche
TL;DR: The central role for osteoblasts in hematopoietic stem cell regulation is reviewed herein from the perspectives of historical context, the role of the osteoblast in supporting stem cell survival, proliferation, and maintenance, and possible future directions for investigation.
Journal ArticleDOI
Adult stem cell plasticity
Richard Poulsom,Malcolm R. Alison,Stuart J. Forbes,Stuart J. Forbes,Nicholas A. Wright,Nicholas A. Wright +5 more
TL;DR: Some of the evidence for stem cell plasticity in rodents and man is reviewed, finding that appropriately differentiated cells are delivered deep within organs simply by injection of bone marrow cells, and should make us think differently about the way that organs regenerate and repair.
Book ChapterDOI
Mesenchymal Stem Cells and Osteoblast Differentiation
TL;DR: This chapter suggests that bone has the potential to repair itself throughout the life of an organism through the coordinated activities of osteoclasts, derived from hemopoietic stem cells, and osteoblasts, and calls for further research efforts to be done to define both MSC and osteoprogenitor number and differentiation capacity in normal aging and in various disease states including osteoporosis.
Journal ArticleDOI
The bone marrow niche: habitat to hematopoietic and mesenchymal stem cells, and unwitting host to molecular parasites.
TL;DR: This review focuses on what is known about the physical structures of the niche, how the niche participates in hematopoiesis and neoplastic growth and what molecules are involved.
Journal ArticleDOI
Hematopoietic Stem Cells Regulate Mesenchymal Stromal Cell Induction into Osteoblasts Thereby Participating in The Formation of the Stem Cell Niche
Younghun Jung,Junhui Song,Yusuke Shiozawa,Jingcheng Wang,Zhuo Wang,Benjamin Williams,Aaron M. Havens,Abraham Schneider,Chunxi Ge,Renny T. Franceschi,Laurie K. McCauley,Paul H. Krebsbach,Russell S. Taichman +12 more
TL;DR: A coupling between HSC functions and bone turnover as in aging and in osteoporosis is suggested, and for the first time, results demonstrate that HSCs do not rest passively in their niche and directly participate in bone formation and niche activities.
References
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Journal ArticleDOI
Bone Marrow, Cytokines, and Bone Remodeling — Emerging Insights into the Pathophysiology of Osteoporosis
TL;DR: Changes in the numbers of bone cells, rather than changes in the activity of individual cells, form the pathogenetic basis of osteoporosis is a major advance in understanding the mechanism of this disease.
Journal ArticleDOI
The STRO-1+ fraction of adult human bone marrow contains the osteogenic precursors
TL;DR: This work provides direct evidence that adult human bone marrow-derived CFU-F are capable of differentiating into functional osteoblasts and that osteoprogenitors are present in the STRO-1+ population.
Journal ArticleDOI
Isolation and characterization of osteoblast precursor cells from human bone marrow
David J. Rickard,Moustapha Kassem,Theresa E. Hefferan,Gobinda Sarkar,Thomas C. Spelsberg,B. Lawrence Riggs +5 more
TL;DR: A negative immunoselection procedure to remove contaminating hematopoietic cells and to isolate nearly homogeneous populations of early human stromal cells derived from the plastic‐adherent mononuclear marrow cells cultured in the presence of serum have the characteristics of authentic human osteoblast precursor cells which also are capable of differentiating into adipocytes.
Journal ArticleDOI
Human osteoblasts support human hematopoietic progenitor cells in vitro bone marrow cultures
TL;DR: The ability of osteoblasts to support the development of hematopoietic colonies from progenitors as well the ability to maintain long-term culture-initiating cells (LTC-IC) in vitro is examined.
Journal ArticleDOI
CD34 expression by stromal precursors in normal human adult bone marrow.
TL;DR: Experiments showed that although the precursors of the hematopoietic and stromal systems share expression of CD34, they are otherwise phenotypically distinct cell types.