Bone tissue bioprinting for craniofacial reconstruction.
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TLDR
This review presents and analyzes the current state of bioprinting of bone tissue and highlights how these techniques may be adapted to serve regenerative therapies for CF applications.Abstract:
Craniofacial (CF) tissue is an architecturally complex tissue consisting of both bone and soft tissues with significant patient specific variations. Conditions of congenital abnormalities, tumor resection surgeries, and traumatic injuries of the CF skeleton can result in major deficits of bone tissue. Despite advances in surgical reconstruction techniques, management of CF osseous deficits remains a challenge. Due its inherent versatility, bioprinting offers a promising solution to address these issues. In this review, we present and analyze the current state of bioprinting of bone tissue and highlight how these techniques may be adapted to serve regenerative therapies for CF applications. Biotechnol. Bioeng. 2017;114: 2424-2431. © 2017 Wiley Periodicals, Inc.read more
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Essential steps in bioprinting: From pre- to post-bioprinting
TL;DR: This review, for the first time, puts all the bioprinting stages in perspective of the whole process of biopprinting, and analyzes their current state of the art.
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Advances on Bone Substitutes through 3D Bioprinting.
TL;DR: The purpose of the present review is to give a comprehensive summary of the past, the present, and future developments of bone bioprinting and bioinks, focusing the attention on crucial aspects of bone regenerative medicine such as selecting cell sources and attaining a viable vascularization within the newly printed bone.
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Advances in three-dimensional bioprinting of bone: Progress and challenges.
TL;DR: The recent advancements in bioprinting of bone, their limitations, challenges, and strategies for future improvisations are summarized to provide deep insights on current understanding of the cellular interactions with the hydrogel matrices and help to unravel new methodologies for facilitating precisely regulated stem cell behaviour.
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In situ three-dimensional printing for reparative and regenerative therapy.
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TL;DR: In situ 3D bioprinting could be combined with cells freshly isolated from patients to produce custom-made grafts that resemble target tissue and fit precisely to target defects, resulting in tissue regeneration and repair.
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3D printing of poly(ε-caprolactone)/poly(D,L-lactide-co-glycolide)/hydroxyapatite composite constructs for bone tissue engineering
Kazim K. Moncal,Dong Nyoung Heo,Kevin P. Godzik,Donna M. Sosnoski,Oliver D. Mrowczynski,Elias Rizk,Veli Ozbolat,Scott M. Tucker,Ethan Gerhard,Madhuri Dey,Gregory S. Lewis,Jian Yang,Ibrahim T. Ozbolat +12 more
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References
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A 3D bioprinting system to produce human-scale tissue constructs with structural integrity
TL;DR: An integrated tissue–organ printer (ITOP) that can fabricate stable, human-scale tissue constructs of any shape is presented and the incorporation of microchannels into the tissue constructs facilitates diffusion of nutrients to printed cells, thereby overcoming the diffusion limit of 100–200 μm for cell survival in engineered tissues.
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TL;DR: This paper presents the first comprehensive review of existing bioink types including hydrogels, cell aggregates, microcarriers and decellularized matrix components used in extrusion-, droplet- and laser-based bioprinting processes.
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Engineering craniofacial scaffolds
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TL;DR: Integrated image-based design and solid free-form fabrication can create scaffolds that attain desired elasticity and permeability while fitting any 3D craniofacial defect, suggesting that designed scaffolds are clinically applicable for complex cranioFacial reconstruction.
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Inkjet-bioprinted acrylated peptides and PEG hydrogel with human mesenchymal stem cells promote robust bone and cartilage formation with minimal printhead clogging.
TL;DR: Collectively, bioprinted PEG-peptide scaffold and hMSCs significantly enhanced osteogenic and chondrogenic differentiation for robust bone and cartilage formation with minimal printhead clogging.