Open AccessJournal Article
Brain Na(+), K(+)-ATPase Activity In Aging and Disease.
de Lores Arnaiz Gr,Ordieres Mg +1 more
TLDR
Evidence showing Na+, K+-ATPase involvement in signaling pathways, enzyme changes in diverse neurological diseases as well as during aging, have been summarized.Abstract:
Fil: Rodriguez, Georgina Emma. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Biologia Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biologia Celular y Neurociencia; Argentinaread more
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Metabolic Dysfunction and Oxidative Stress in Epilepsy.
TL;DR: The evidence that metabolic and redox disruption is both cause and consequence of epileptic seizures is focused on and the promise of targeting redox processes as a therapeutic option in epilepsy is discussed.
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Beyond symptomatic relief for chemotherapy-induced peripheral neuropathy: Targeting the source.
TL;DR: The potential to prevent or reverse CIPN by protecting mitochondria and/or inhibiting nitro‐oxidative stress with novel potential drugs, including the mitochondrial protectant pifithrin‐μ, histone deacetylase 6 inhibitors, metformin, antioxidants, peroxynitrite decomposition catalysts, and anti‐inflammatory mediators including interleukin 10 are discussed.
Journal ArticleDOI
Aging and the Epidemiology of Epilepsy.
Ettore Beghi,Giorgia Giussani +1 more
TL;DR: As the world population is steadily growing with parallel increase in the number of aged subjects, in the future, epilepsy will represent a huge burden for the society and measures must be taken to prevent seizures and epilepsy through the reduction of preventable epileptogenic factors.
Journal ArticleDOI
Quantitative sodium MR imaging: A review of its evolving role in medicine.
TL;DR: The vital roles of sodium ion in membrane transport and the extracellular matrix will be reviewed to indicate the broad opportunities that now exist for clinical sodium MR imaging.
Journal ArticleDOI
Calcineurin signaling in the heart: The importance of time and place
TL;DR: The wide range of calcineurin substrates relevant to cardiovascular health and the mechanisms calcineURin uses to find and act on appropriate substrates in the appropriate location while potentially avoiding others are discussed.
References
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Journal Article
The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.
TL;DR: The cytotoxic action of both these diabetogenic agents is mediated by reactive oxygen species, however, the source of their generation is different in the case of alloxan and streptozotocin.
Journal ArticleDOI
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
TL;DR: Leg nerves from the shore crab contain an adenosine triphosphatase which is located in the submicroscopic particles, and the influence of sodium, potassium, magnesium and calcium ions on this enzyme has been investigated.
Journal ArticleDOI
The influence of some cations on an adenosine triphosphatase from peripheral nerves.
TL;DR: In this article, the authors investigated the influence of different cations on the activity of an adenosine triphosphatase (ATP) enzyme in the leg nerves of crabs.
Journal ArticleDOI
Calcineurin : form and function
Frank Rusnak,Pamela Mertz +1 more
TL;DR: This review provides a comprehensive examination of the biological roles of calcineurin and reviews aspects related to its structure and catalytic mechanism.