Journal ArticleDOI
Brain targeting effect of camptothecin-loaded solid lipid nanoparticles in rat after intravenous administration.
TLDR
In vivo biodistribution studies of intravenous camptothecin-loaded SLN performed in rats proved the positive role of SLN on the brain targeting since significant higher brain accumulation of campthecin was observed, compared to non-encapsulated drug.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 2013-11-01. It has received 109 citations till now. The article focuses on the topics: Camptothecin.read more
Citations
More filters
Journal ArticleDOI
Progress and perspectives on targeting nanoparticles for brain drug delivery.
TL;DR: In this review, the barriers to brain-targeted drug delivery are reviewed, including the BBB, blood–brain tumor barrier (BBTB), and nose-to-brain barrier, and delivery strategies are focused on overcoming theBBB, directly targeting diseased cells in the brain, and dual- targeted delivery.
Journal ArticleDOI
Nanotoxicology applied to solid lipid nanoparticles and nanostructured lipid carriers - a systematic review of in vitro data.
TL;DR: This review collected the available data from cytotoxicity, oxidative stress and hemocompatibility studies in vitro and analysed their outcomes and provided a summary of the availableData in a form of reference table.
Journal ArticleDOI
Advances in the design of solid lipid nanoparticles and nanostructured lipid carriers for targeting brain diseases.
TL;DR: In this review, a presentation of the most important brain diseases (brain cancer, ischemic stroke, Alzheimer's disease, Parkinson's disease and multiple sclerosis) is approached, followed by the basic fabrication techniques of SLNs and NLCs.
Journal ArticleDOI
Nanotechnology-based drug delivery systems for the treatment of Alzheimer's disease.
TL;DR: A systematic review of nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease finds each are promising tools for the delivery of therapeutic devices to the brain via various routes of administration, particularly the intranasal route.
Journal ArticleDOI
Solid lipid nanoparticles as vehicles of drugs to the brain: current state of the art.
Lucia Gastaldi,Luigi Battaglia,Elena Peira,Daniela Chirio,Elisabetta Muntoni,I. Solazzi,Marina Gallarate,Franco Dosio +7 more
TL;DR: This review examines the main aspects surrounding brain delivery with SLN, and illustrates the principal mechanisms used to enhance brain uptake of the delivered drug.
References
More filters
Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Factors Affecting the Clearance and Biodistribution of Polymeric Nanoparticles
TL;DR: These factors have been shown to substantially affect the biodistribution and blood circulation half-life of circulating nanoparticles by reducing the level of nonspecific uptake, delaying opsonization, and increasing the extent of tissue specific accumulation.
Journal ArticleDOI
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more
TL;DR: An overview about the selection of the ingredients, different ways of SLN production and SLN applications, and the in vivo fate of the carrier are presented.
Related Papers (5)
Solid lipid nanoparticles: Production, characterization and applications
W. Mehnert,Karsten Mäder +1 more