Journal ArticleDOI
Brain tissue reaction to some chronically implanted metals
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The toxicity of certain metals was evaluated histologically following chronic implantation for 2 months in the brains of cats and all but silver were found to be nontoxic.Abstract:
✓ The toxicity of certain metals, namely, platinum, platinum-8% tungsten, platinum-10% rhodium, platinum-10% iridium, platinum-10% nickel, platinized platinum, a gold-nickel-chromium alloy, a gold-palladium-rhodium alloy, a chromium-nickel-molybdenum alloy (Vitallium), stainless steel, silver, rhenium, and gold, was evaluated histologically following chronic implantation for 2 months in the brains of cats. Of the above metals, all but silver were found to be nontoxic. Boron was also evaluated and found to be nontoxic.read more
Citations
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Electrical stimulation of excitable tissue: design of efficacious and safe protocols.
TL;DR: The physical basis for electrical stimulation of excitable tissue, as used by electrophysiological researchers and clinicians in functional electrical stimulation, is presented with emphasis on the fundamental mechanisms of charge injection at the electrode/tissue interface.
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Electrochemical Considerations for Safe Electrical Stimulation of the Nervous System with Platinum Electrodes
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Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
Mehdi Jorfi,John L. Skousen,John L. Skousen,Christoph Weder,Jeffrey R. Capadona,Jeffrey R. Capadona +5 more
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References
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Journal ArticleDOI
Metals for implantation in the human body
TL;DR: In the field of metal implants, the authors are fortunate to have several alloys with many years of acceptable clinical experience which can serve as a standard of comparison or control in any test procedure designed to aid in the choice of a metal for implants.
Journal ArticleDOI
Controlled multifocal frontal leucotomy for psychiatric illness.
TL;DR: The introduction of methods for selection andlimitation for selection of patients with chronic depressives and those with anxiety states, andobsessional syndromes whose symptomshaveproved intractable, so as to bring significant andprolonged relief of symptoms to the patient.
Histopathological studies of tissue reactions to various metals implanted in cat brains.
TL;DR: Metal rods of gold, platinum, silver, stainless steel, tantalum, and tungsten were implanted in cat brain tissue and the resulting changes were observed for as long as 6 months indicating a preference of metals to be used in the fabrication of intracerebral electrodes from the standpoint of tissue reaction.