Journal ArticleDOI
Broad-spectrum antimicrobial efficacy of peptide A3-APO in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved.
Eszter Ostorházi,Marianna Csilla Holub,Ferenc Rozgonyi,Ferenc Harmos,Marco Cassone,John D. Wade,Laszlo Otvos +6 more
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TLDR
The designer proline-rich antimicrobial peptide A3-APO shows superior efficacy compared with conventional antibiotics in mouse models of systemic and wound infections and when administered intramuscularly or as an aerosol it significantly improved mouse survival and reduced bacterial counts at the infection site and in blood.About:
This article is published in International Journal of Antimicrobial Agents.The article was published on 2011-05-01. It has received 55 citations till now. The article focuses on the topics: Antibiotics & Staphylococcus aureus.read more
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The Acinetobacter baumannii Oxymoron: Commensal Hospital Dweller Turned Pan-Drug-Resistant Menace.
TL;DR: The pathogenesis of the infections caused by this microorganism as well as the molecular bases of antibacterial resistance and clinical aspects such as treatment and potential future therapeutic strategies are discussed in depth.
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Antimicrobial peptides and wound healing: biological and therapeutic considerations
TL;DR: The evidence for a role of AMPs as endogenous mediators of wound healing and their promising therapeutic potential for the treatment of non‐life‐threatening skin and other epithelial injuries is provided.
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Insect‐Derived Proline‐Rich Antimicrobial Peptides Kill Bacteria by Inhibiting Bacterial Protein Translation at the 70 S Ribosome
TL;DR: Both apidaecins and oncocins were shown to bind with nanomolar dissociation constants to the 70S ribosome, and the chaperone DnaK is most likely not the main target of PrAMPs but it binds them with lower affinity.
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Proline-rich antimicrobial peptides: potential therapeutics against antibiotic-resistant bacteria
Wenyi Li,Julien Tailhades,Neil M O'Brien-Simpson,Frances Separovic,Laszlo Otvos,M. Akhter Hossain,John D. Wade +6 more
TL;DR: Proline-rich antimicrobial peptides display the ability to not only modulate the immune system via cytokine activity or angiogenesis but also possess properties of penetrating cell membranes and crossing the blood brain barrier suggesting a role as potential novel carriers.
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The Vast Structural Diversity of Antimicrobial Peptides.
Johannes Koehbach,David J. Craik +1 more
TL;DR: The structures of AMPs from the four main classes currently recognized - that is, peptides with α-helical, β-sheet, αβ, or non-αβ elements - as well as the growing pool of complex topologies including various post-translational modifications (PTMs) are discussed.
References
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Modulation of the TLR-Mediated Inflammatory Response by the Endogenous Human Host Defense Peptide LL-37
Neeloffer Mookherjee,Kelly L. Brown,Dawn M. E. Bowdish,Silvana Doria,Reza Falsafi,Karsten Hokamp,Fiona M. Roche,Ruixia Mu,Gregory H. Doho,Jelena Pistolic,Jon-Paul S. Powers,Jenny Bryan,Fiona S. L. Brinkman,Robert E. W. Hancock +13 more
TL;DR: It is proposed that the natural human host defense peptide LL-37 plays roles in the delicate balancing of inflammatory responses in homeostasis as well as in combating sepsis induced by certain TLR agonists.
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Complicated skin and soft tissue infection
TL;DR: A range of new agents for the treatment of methicillin-resistant S. aureus infections have compared favourably with the glycopeptides and some have distinct pharmacokinetic advantages.
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High-Dose Leptin Activates Human Leukocytes Via Receptor Expression on Monocytes
Hamid Zarkesh-Esfahani,Graham Pockley,R. A. Metcalfe,Martin Bidlingmaier,Zida Wu,Abolghasem Ajami,Anthony P. Weetman,Christian J. Strasburger,Richard J. Ross +8 more
TL;DR: It is demonstrated that leptin has a direct effect on the generation of an inflammatory response, and is of relevance when considering leptin therapy and may partly explain the relationship among leptin, proinflammatory cytokines, insulin resistance, and obesity.
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Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis
Luciana Santos Cardoso,Maria Ilma Araujo,Maria Ilma Araujo,Alfredo M. Goes,Lucila G. G. Pacifico,Ricardo Riccio Oliveira,Sergio C. Oliveira +6 more
TL;DR: Polymyxin B was able to neutralize the effect of endotoxin, as contaminant in S. mansoni recombinant antigens produced in E. coli, in inducing TNF-α and IL-10 production.
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Host Defense Peptide LL-37, in Synergy with Inflammatory Mediator IL-1β, Augments Immune Responses by Multiple Pathways
Jie Yu,Neeloffer Mookherjee,Kathleen Wee,Dawn M. E. Bowdish,Jelena Pistolic,Yuexin Li,Linda Rehaume,Robert E. W. Hancock +7 more
TL;DR: Results together indicate that the human host defense peptide LL-37 can work in synergy with the endogenous inflammatory mediator IL-1β to enhance the induction of specific inflammatory effectors by a complex mechanism involving multiple pathways, thus reinforcing certain innate immune responses.