Bronchial epithelium-derived IL-8 and RANTES increased bronchial smooth muscle cell migration and proliferation by Krüppel-like factor 5 in areca nut-mediated airway remodeling.
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TLDR
This study suggests that inhibition of IL-8 and RANTES orIL-8/RANTES-mediated mitogen-activated protein kinase/KLF5 signaling is an attractive therapeutic target for areca nut-induced asthma.About:
This article is published in Toxicological Sciences.The article was published on 2011-05-01 and is currently open access. It has received 27 citations till now. The article focuses on the topics: Smooth muscle cell migration & Arecoline.read more
Citations
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Journal ArticleDOI
Assembly of a Three-Dimensional Multitype Bronchiole Coculture Model Using Magnetic Levitation
Hubert Tseng,Jacob A. Gage,Robert M. Raphael,Robert H. Moore,Thomas Killian,K. Jane Grande-Allen,Glauco R. Souza +6 more
TL;DR: This study validates magnetic levitation as a method for the rapid creation of organized 3D cocultures that maintain the phenotype and induce extracellular matrix formation.
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YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK and ERK) and NF-κB pathways, causing bronchial smooth muscle proliferation and migration.
TL;DR: In this paper, the authors investigated the mechanisms involved in YKL-40-mediated inflammation in human bronchial epithelial cells (HBECs) and analyzed the soluble factors secreted by HBECs exposed to the chitinase-like glycoprotein, which were responsible for increasing proliferation and migration of primary normal human Bronchial smooth muscle cells (BSMCs).
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Analysis of a Panel of 48 Cytokines in BAL Fluids Specifically Identifies IL-8 Levels as the Only Cytokine that Distinguishes Controlled Asthma from Uncontrolled Asthma, and Correlates Inversely with FEV1
Koa Hosoki,Sun Ying,Christopher Corrigan,H. Qi,Alexander Kurosky,Kristofer Jennings,Qian Sun,Istvan Boldogh,Sanjiv Sur +8 more
TL;DR: Results identify neutrophils and IL-8 are the only inflammatory components in BAL fluids that distinguish controlled asthma from uncontrolled asthma, and both correlate inversely with FEV1.
Journal Article
YKL-40 induces IL-8 expression from bronchial epithelium via MAPK (JNK, ERK1/2) and NF-κB pathways, causing bronchial smooth muscle proliferation and migration
TL;DR: The findings implicate that YKL-40 may be involved in the inflammation of asthma by induction of IL-8 from epithelium, subsequently contributing to BSMC proliferation and migration.
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KLF5 activates microRNA 200 transcription to maintain epithelial characteristics and prevent induced epithelial-mesenchymal transition in epithelial cells.
Baotong Zhang,Zhiqian Zhang,Zhiqian Zhang,Siyuan Xia,Changsheng Xing,Changsheng Xing,Xinpei Ci,Xin Li,Ranran Zhao,Sha Tian,Gui Ma,Zhengmao Zhu,Liya Fu,Jin-Tang Dong,Jin-Tang Dong +14 more
TL;DR: It is found that KLF5 maintains epithelial characteristics and prevents EMT by transcriptionally activating the miR-200 family in epithelial cells.
References
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Airway Structural Alterations Selectively Associated with Severe Asthma
TL;DR: It is concluded that fibroblast accumulation and ASM hypertrophy in proximal airways are selective determinants of severe persistent asthma.
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Remodeling in asthma
TL;DR: Airway remodeling encompasses the structural alterations in asthmatic compared with normal airways, and is assumed to result in persistent airflow limitation, a decrease in lung function, and airway hyperresponsiveness.
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Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Yumiko Oishi,Ichiro Manabe,Kazuyuki Tobe,Kensuke Tsushima,Takayuki Shindo,Katsuhito Fujiu,Go Nishimura,Koji Maemura,Toshimasa Yamauchi,Naoto Kubota,Ryo Suzuki,Toshio Kitamura,Shizuo Akira,Takashi Kadowaki,Ryozo Nagai +14 more
TL;DR: Krüppel-like factor 5 is established as a key component of the transcription factor network controlling adipocyte differentiation, and embryonic fibroblasts obtained from KLF5+/- mice showed much attenuated adipocytes differentiation, confirming the key role played by KLf5 in adipocyte differentiate.
Journal Article
Epidemiology of betel quid usage.
Prakash C. Gupta,Cecily S. Ray +1 more
TL;DR: Use of areca nut in any form is not safe for oral health; the use of commercially manufactured forms seems even riskier.
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The regulatory role of TGF-β in airway remodeling in asthma
TL;DR: Reduction of TGF‐β production and control of T GF‐β effects would be beneficial in the development of therapeutic intervention for airway remodeling in chronic asthma.