R
Ryo Suzuki
Researcher at University of Colorado Boulder
Publications - 127
Citations - 6541
Ryo Suzuki is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Computer science & Insulin resistance. The author has an hindex of 25, co-authored 88 publications receiving 5601 citations. Previous affiliations of Ryo Suzuki include Southeast University & Ehime University.
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Journal ArticleDOI
Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 gene
William S. Chen,Pei Zhang Xu,Kathrin Gottlob,Mei Ling Chen,Karen Sokol,Tanya Shiyanova,Igor B. Roninson,Wei Weng,Ryo Suzuki,Kazuyuki Tobe,Takashi Kadowaki,Nissim Hay +11 more
TL;DR: The disruption of the most ubiquitously expressed member of the akt family of genes, akt1, in the mouse is reported, resulting in viable but smaller mice and mice that are more susceptible to apoptosis induced by TNF, anti-Fas, UV irradiation, and serum withdrawal.
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Overexpression of Monocyte Chemoattractant Protein-1 in Adipose Tissues Causes Macrophage Recruitment and Insulin Resistance
Nozomu Kamei,Kazuyuki Tobe,Ryo Suzuki,Mitsuru Ohsugi,Taku Watanabe,Naoto Kubota,Norie Ohtsuka-Kowatari,Katsuyoshi Kumagai,Kentaro Q. Sakamoto,Masatoshi Kobayashi,Toshimasa Yamauchi,Kohjiro Ueki,Yumiko Oishi,Satoshi Nishimura,Ichiro Manabe,Haruo Hashimoto,Yasuyuki Ohnishi,Hitomi Ogata,Kumpei Tokuyama,Masaki Tsunoda,Tomohiro Ide,Koji Murakami,Ryozo Nagai,Takashi Kadowaki +23 more
TL;DR: It is concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-M CP-1 mice.
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Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
Naoto Kubota,Wataru Yano,Tetsuya Kubota,Tetsuya Kubota,Toshimasa Yamauchi,Shinsuke Itoh,Hiroki Kumagai,Hideki Kozono,Iseki Takamoto,Shiki Okamoto,Tetsuya Shiuchi,Ryo Suzuki,Hidemi Satoh,Atsushi Tsuchida,Masao Moroi,Kaoru Sugi,Tetsuo Noda,Tetsuo Noda,Hiroyuki Ebinuma,Yoichi Ueta,Tatsuya Kondo,Eiichi Araki,Osamu Ezaki,Ryozo Nagai,Kazuyuki Tobe,Yasuo Terauchi,Kohjiro Ueki,Yasuhiko Minokoshi,Takashi Kadowaki +28 more
TL;DR: It is shown that adiponectin stimulates food intake and decreases energy expenditure during fasting through its effects in the central nervous system via its receptor AdipoR1 to stimulate food intake.
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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Naoto Kubota,Kazuyuki Tobe,Yasuo Terauchi,Kazuhiro Eto,Toshimasa Yamauchi,Ryo Suzuki,Yoshiharu Tsubamoto,Kajuro Komeda,Ryosuke Nakano,Hiroshi Miki,Shinobu Satoh,Hisahiko Sekihara,Salvatore Sciacchitano,Maxine A. Lesniak,Shinichi Aizawa,Ryozo Nagai,Satoshi Kimura,Yasuo Akanuma,Simeon I. Taylor,Takashi Kadowaki +19 more
TL;DR: The results suggest that IRS-1 and IRS-2 may play different roles in the regulation of beta-cell mass and the function of individual beta-cells.
Journal ArticleDOI
Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.
Yumiko Oishi,Ichiro Manabe,Kazuyuki Tobe,Kensuke Tsushima,Takayuki Shindo,Katsuhito Fujiu,Go Nishimura,Koji Maemura,Toshimasa Yamauchi,Naoto Kubota,Ryo Suzuki,Toshio Kitamura,Shizuo Akira,Takashi Kadowaki,Ryozo Nagai +14 more
TL;DR: Krüppel-like factor 5 is established as a key component of the transcription factor network controlling adipocyte differentiation, and embryonic fibroblasts obtained from KLF5+/- mice showed much attenuated adipocytes differentiation, confirming the key role played by KLf5 in adipocyte differentiate.