Journal ArticleDOI
Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: a potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints.
TLDR
The data show that activation of human platelets triggered by convulxin or collagen, specific ligands for GPVI receptor, or alternatively by antibody-mediated cross-linking of another platelet receptor, C type lectin-like receptor 2 (CLEC2), resulted in phosphorylation of BTK and downstream effector, phospholipase Cγ2 (PLCγ2).About:
This article is published in Immunology Letters.The article was published on 2013-02-01. It has received 36 citations till now. The article focuses on the topics: GPVI & Bruton's tyrosine kinase.read more
Citations
More filters
Journal ArticleDOI
Functional significance of the platelet immune receptors GPVI and CLEC-2.
TL;DR: The physiological and pathological roles of CLEC-2 and GPVI are discussed and their potential as targets in thrombosis and thrombo-inflammatory disorders (i.e., disorders in which inflammation plays a critical role in the ensuing thromBosis) relative to current antiplatelet drugs are discussed.
Journal ArticleDOI
Bruton's tyrosine kinase--an integral protein of B cell development that also has an essential role in the innate immune system.
Gabriela López-Herrera,Alexander Vargas-Hernández,Maria Edith González-Serrano,Laura Berrón-Ruiz,Juan Carlos Rodríguez-Alba,Francisco J. Espinosa-Rosales,Leopoldo Santos-Argumedo +6 more
TL;DR: This review focuses on the function of Btk in monocytes, neutrophils, and platelets and the receptors and signaling cascades in such cells with which Btk is associated.
Journal ArticleDOI
Targeting the SYK–BTK axis for the treatment of immunological and hematological disorders: Recent progress and therapeutic perspectives
TL;DR: Recent insights into the emerging role of the SYK-BTK axis in innate immune cell function as well as in the maintenance of survival and homing signals for tumor cell progression are discussed.
Journal ArticleDOI
Platelets: emerging facilitators of cellular crosstalk in rheumatoid arthritis.
TL;DR: The role of platelets in rheumatoid arthritis is highlighted and the need to closely examine platelets as health indicators when designing effective pharmaceutical targets in this disease is examined.
Journal ArticleDOI
Clinicopathological correlations of podoplanin (gp38) expression in rheumatoid synovium and its potential contribution to fibroblast platelet crosstalk.
Manuel J. Del Rey,Regina Faré,Elena Izquierdo,Alicia Usategui,José Luis Rodríguez-Fernández,Abel Suárez-Fueyo,Juan D. Cañete,José L. Pablos +7 more
TL;DR: In RA, synovial expression of gp38 is strongly associated to LN and it is reduced after anti-TNF-α therapy, while interaction between gp38 and CLEC2 platelet receptor is feasible in RA synovium in vivo and can specifically contribute to gene expression by SF.
References
More filters
Journal ArticleDOI
Aggregation of blood platelets by adenosine diphosphate and its reversal.
Journal ArticleDOI
Platelets and the immune continuum
TL;DR: The mechanisms by which platelets contribute to immunity are discussed: these small cells are more immunologically savvy than the authors once thought.
Journal ArticleDOI
Platelets in inflammation and atherogenesis
TL;DR: This Review highlights the molecular machinery and inflammatory pathways used by platelets to initiate and accelerate atherothrombosis.
Journal ArticleDOI
Platelet-collagen interaction: is GPVI the central receptor?
TL;DR: Recent developments in understanding platelet-collagen interactions are discussed and possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis are proposed.
Journal ArticleDOI
The SYK tyrosine kinase: a crucial player in diverse biological functions.
TL;DR: Current understanding of the diverse functions of SYK is summarized and how this is being translated for therapeutic purposes is summarized.