Journal ArticleDOI
C-cadherin ectodomain structure and implications for cell adhesion mechanisms
Titus J. Boggon,John Murray,Sophie Chappuis-Flament,Ellen Wong,Barry M. Gumbiner,Lawrence Shapiro +5 more
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TLDR
The 3.1 angstrom resolution crystal structure of the whole, functional extracellular domain from C-cadherin is presented, a representative “classical” cadherin that suggests a molecular mechanism for adhesion between cells by classical cadherins and provides a new framework for understanding both cis (same cell) and trans (juxtaposed cell) caderin interactions.Abstract:
Cadherins are transmembrane proteins that mediate adhesion between cells in the solid tissues of animals. Here we present the 3.1 angstrom resolution crystal structure of the whole, functional extracellular domain from C-cadherin, a representative “classical” cadherin. The structure suggests a molecular mechanism for adhesion between cells by classical cadherins, and it provides a new framework for understanding both cis (same cell) and trans (juxtaposed cell) cadherin interactions. The trans adhesive interface is a twofold symmetric interaction defined by a conserved tryptophan side chain at the membrane-distal end of a cadherin molecule from one cell, which inserts into a hydrophobic pocket at the membrane-distal end of a cadherin molecule from the opposing cell.read more
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Journal ArticleDOI
Regulation of cadherin-mediated adhesion in morphogenesis
TL;DR: Cadherin cell-adhesion proteins mediate many facets of tissue morphogenesis, and the dynamic regulation of cadherins in response to various extracellular signals controls cell sorting, cell rearrangements and cell movements.
Journal ArticleDOI
The cell-cell adhesion molecule E-cadherin
F. Van Roy,Geert Berx +1 more
TL;DR: The multiple mechanisms that disrupt E-cadherin function in cancer are reviewed: inactivating somatic and germline mutations, epigenetic silencing by DNA methylation and epithelial to mesenchymal transition-inducing transcription factors, and dysregulated protein processing.
Journal ArticleDOI
VE-Cadherin The Major Endothelial Adhesion Molecule Controlling Cellular Junctions and Blood Vessel Formation
TL;DR: This review will focus on recent new developments in understanding the role of VE-cadherin in controlling endothelial cell contacts and influencing endothelium cell behavior by various outside-in signaling processes.
Journal ArticleDOI
Cadherins as modulators of cellular phenotype.
TL;DR: Cadherins have been implicated in a number of signaling pathways that regulate cellular behavior, and it is becoming increasingly clear that integration of information received from cell-cell signaling, cell-matrix signaling, and growth factor signaling determines ultimate cellular phenotype and behavior.
Journal ArticleDOI
Cadherin 23 and protocadherin 15 interact to form tip-link filaments in sensory hair cells.
Piotr Kazmierczak,Hirofumi Sakaguchi,Joshua Tokita,Elizabeth M. Wilson-Kubalek,Ronald A. Milligan,Ulrich Müller,Bechara Kachar +6 more
TL;DR: The studies define the molecular composition of tip links and provide a conceptual base for exploring the mechanisms of sensory impairment associated with mutations in CDH23 and PCDH15.
References
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Journal ArticleDOI
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Journal ArticleDOI
The CCP4 suite: programs for protein crystallography
TL;DR: The CCP4 (Collaborative Computational Project, number 4) program suite is a collection of programs and associated data and subroutine libraries which can be used for macromolecular structure determination by X-ray crystallography.
Journal ArticleDOI
Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons.
TL;DR: It is demonstrated in this work that the surface tension, water‐organic solvent, transfer‐free energies and the thermodynamics of melting of linear alkanes provide fundamental insights into the nonpolar driving forces for protein folding and protein binding reactions.
Journal ArticleDOI
Cadherins: A Molecular Family Important in Selective Cell-Cell Adhesion
TL;DR: This paper presents a meta-analyses of cDNA transference studies on CADherin FUNCTION and discusses the role of CADherins 1N MORPHOGENESIS in this research.
Book ChapterDOI
Structure and function of intercellular junctions.
TL;DR: This chapter reviews the morphological information on intercellular junctions derived from thin-sectioning, negative staining and freeze-cleave techniques, as well as from x-ray diffraction and biochemical investigations, and correlates the structural parameters with known or proposed physiological functions.