Canceling actions involves a race between basal ganglia pathways
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The results support race models of action cancellation, with stopping requiring Stop-cue information to be transmitted from STN to SNr before increased striatal input creates a point of no return.Abstract:
Salient cues can prompt the rapid interruption of planned actions. It has been proposed that fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested this by comparing activity in multiple rat basal ganglia structures during performance of a stop-signal task. Subthalamic nucleus (STN) neurons exhibited low-latency responses to 'Stop' cues, irrespective of whether actions were canceled or not. By contrast, neurons downstream in the substantia nigra pars reticulata (SNr) only responded to Stop cues in trials with successful cancellation. Recordings and simulations together indicate that this sensorimotor gating arises from the relative timing of two distinct inputs to neurons in the SNr dorsolateral 'core' subregion: cue-related excitation from STN and movement-related inhibition from striatum. Our results support race models of action cancellation, with stopping requiring Stop-cue information to be transmitted from STN to SNr before increased striatal input creates a point of no return.read more
Citations
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Book ChapterDOI
The Subthalamic Nucleus
TL;DR: The morphological, synaptic, and integrative properties of STN neurons and the relationship of their activity patterns in vivo to both normal and abnormal behavior are reviewed.
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Brain compensation during response inhibition in premanifest Huntington's disease.
Maria V. Soloveva,Sharna D. Jamadar,Sharna D. Jamadar,Sharna D. Jamadar,Matthew Hughes,Dennis Velakoulis,Govinda Poudel,Govinda Poudel,Nellie Georgiou-Karistianis +8 more
TL;DR: The findings suggest a compensatory process of the response inhibition network in pre-HD; however, the pattern of fMRI activity was not in the manner expected by CRUNCH.
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Yixin Pan,Linbin Wang,Yingying Zhang,Chencheng Zhang,Xian Qiu,Yuyan Tan,Haiyan Zhou,Bomin Sun,Dianyou Li +8 more
TL;DR: GPi-DBS may lead to an increase in response initiation speed and improve the dysfunctional proactive inhibitory control observed in PD patients, and may help to understand the role of the GPi in cortical-basal ganglia circuits.
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Yohann Thenaisie,Kyuhwa Lee,C. Moerman,Stefano Scafa,Andrea Gálvez,Elvira Pirondini,Morgane Burri,Jimmy Ravier,Alessandro Puiatti,Ettore A. Accolla,Benoît Wicki,Andre Zacharia,Mayte Castro Jiménez,Julien Bally,Grégoire Courtine,Jocelyne Bloch,Eduardo Martin Moraud +16 more
TL;DR: This work exploited a neurorobotic platform to demonstrate that the subthalamic nucleus encodes the initiation, termination, and vigor of leg muscle activation, and found that the same fundamental principles determine the encoding of walking.
Journal ArticleDOI
Striatal activity during reactive inhibition is related to the expectation of stop-signals
TL;DR: It is found that striatal activity during reactive inhibition was higher when subjects expected stop signals, helping explain conflicting findings of previous studies on the association between striatal activation and inhibition.
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