Canceling actions involves a race between basal ganglia pathways
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The results support race models of action cancellation, with stopping requiring Stop-cue information to be transmitted from STN to SNr before increased striatal input creates a point of no return.Abstract:
Salient cues can prompt the rapid interruption of planned actions. It has been proposed that fast, reactive behavioral inhibition involves specific basal ganglia pathways, and we tested this by comparing activity in multiple rat basal ganglia structures during performance of a stop-signal task. Subthalamic nucleus (STN) neurons exhibited low-latency responses to 'Stop' cues, irrespective of whether actions were canceled or not. By contrast, neurons downstream in the substantia nigra pars reticulata (SNr) only responded to Stop cues in trials with successful cancellation. Recordings and simulations together indicate that this sensorimotor gating arises from the relative timing of two distinct inputs to neurons in the SNr dorsolateral 'core' subregion: cue-related excitation from STN and movement-related inhibition from striatum. Our results support race models of action cancellation, with stopping requiring Stop-cue information to be transmitted from STN to SNr before increased striatal input creates a point of no return.read more
Citations
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Book ChapterDOI
Mouse models of neurodevelopmental disease of the basal ganglia and associated circuits
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Subthalamic nucleus gamma activity increases not only during movement but also during movement inhibition
Petra Fischer,Alek Pogosyan,Alek Pogosyan,Damian M. Herz,Damian M. Herz,Binith Cheeran,Alexander L. Green,James J. FitzGerald,Tipu Z. Aziz,Jonathan Hyam,Simon Little,Thomas Foltynie,Patricia Limousin,Ludvic Zrinzo,Peter Brown,Peter Brown,Huiling Tan,Huiling Tan +17 more
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Journal ArticleDOI
Dysregulation of external globus pallidus-subthalamic nucleus network dynamics in parkinsonian mice during cortical slow-wave activity and activation.
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TL;DR: It is argued that in parkinsonian mice abnormal, temporally offset prototypic GPe and STN neuron firing results in part from increased striatopallidal transmission and that compensatory plasticity limits STN hyperactivity and cortical entrainment.
References
More filters
Book
The Rat Brain in Stereotaxic Coordinates
George Paxinos,Charles Watson +1 more
TL;DR: This paper presents a meta-analyses of the determinants of earthquake-triggered landsliding in the Czech Republic over a period of 18 months in order to establish a probabilistic framework for estimating the intensity of the earthquake.
Journal ArticleDOI
The functional anatomy of basal ganglia disorders.
TL;DR: A model in which specific types of basal ganglia disorders are associated with changes in the function of subpopulations of striatal projection neurons is proposed, which suggests that the activity of sub Populations of Striatal projections neurons is differentially regulated by striatal afferents and that different striatal projections may mediate different aspects of motor control.
Book
The Handbook of Brain Theory and Neural Networks
TL;DR: A circular cribbage board having a circular base plate on which a circular counter disc, bearing a circular scale having 122 divisions numbered consecutively from 0, is mounted for rotation.
Journal ArticleDOI
Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
TL;DR: The postulated role of excessive activity in the subthalamic nucleus in Parkinson's disease is supported by the effects of lesions evaluated in monkeys rendered parkinsonian by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
Journal ArticleDOI
Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry
Alexxai V. Kravitz,Benjamin S. Freeze,Philip R.L. Parker,Kenneth Kay,Myo T. Thwin,Karl Deisseroth,Anatol C. Kreitzer +6 more
TL;DR: These findings establish a critical role for basal ganglia circuitry in the bidirectional regulation of motor behaviour and indicate that modulation of direct-pathway circuitry may represent an effective therapeutic strategy for ameliorating parkinsonian motor deficits.
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