Journal ArticleDOI
Cation-Chloride Cotransporters in Neuronal Communication.
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TLDR
KCC2, a neuronal-specific isoform of the K(+)-Cl(-) cotransporter, by lowering internal Cl(-), is critical for inhibitory GABA responses in mature central nervous system neurons.Abstract:
Two isoforms of the cation-Cl– cotransporter family are expressed in neurons and modulate neurotransmission. NKCC1, a Na+-K+-2Cl– cotransporter, by raising internal Cl–, is responsible for excitatory GABAergic activity in immature brain and in adult sensory neurons. KCC2, a neuronal-specific isoform of the K+-Cl– cotransporter, by lowering internal Cl–, is critical for inhibitory GABA responses in mature central nervous system neurons.read more
Citations
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Excitatory actions of gaba during development: the nature of the nurture.
TL;DR: This work proposes that GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions, and provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation.
Journal ArticleDOI
Physiology of cell volume regulation in vertebrates.
TL;DR: Current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species are reviewed.
Journal ArticleDOI
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
TL;DR: It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.
Journal ArticleDOI
GABA regulates synaptic integration of newly generated neurons in the adult brain
TL;DR: This study identifies an essential role for GABA in the synaptic integration of newly generated neurons in the adult brain, and suggests an unexpected mechanism for activity-dependent regulation of adult neurogenesis, in which newborn neurons may sense neuronal network activity through tonic and phasic GABA activation.
Journal ArticleDOI
NKCC1 transporter facilitates seizures in the developing brain
Volodymyr Dzhala,Delia M. Talos,Dan A Sdrulla,Audrey C. Brumback,Gregory C. Mathews,Tim A. Benke,Eric Delpire,Frances E. Jensen,Kevin J. Staley +8 more
TL;DR: Evidence that NKCC1 facilitates seizures in the developing brain is provided and indications that bumetanide should be useful in the treatment of neonatal seizures are indicated.
References
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Journal ArticleDOI
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation.
Claudio Rivera,Juha Voipio,John A. Payne,Eva Ruusuvuori,Hannele Lahtinen,Karri Lamsa,Ulla Pirvola,Mart Saarma,Kai Kaila +8 more
TL;DR: It is shown that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABAA-mediated responses from depolarizing to hyperpolarizing is coupled to a developmental induction of the expression of the neuronal Cl−-extruding K+/Cl − co-transporter, KCC2 (ref. 7).
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Excitatory GABA Responses in Embryonic and Neonatal Cortical Slices Demonstrated by Gramicidin Perforated-Patch Recordings and Calcium Imaging
TL;DR: The results suggest that GABAA receptor-mediated depolarization may influence early neocortical developmental events, including neurogenesis and synaptogenesis, through the activation of Ca2+-dependent signal transduction pathways.
Journal ArticleDOI
Molecular Characterization of a Putative K-Cl Cotransporter in Rat Brain A NEURONAL-SPECIFIC ISOFORM
TL;DR: Gillen et al. as discussed by the authors used a combination of data base searching, polymerase chain reaction, and library screening to identify a putative K-Cl cotransporter isoform (KCC2) in rat brain that was specifically localized in neurons.
Journal ArticleDOI
Expression of the Na‐K‐2Cl cotransporter is developmentally regulated in postnatal rat brains: A possible mechanism underlying GABA's excitatory role in immature brain
TL;DR: The hypothesis that the Na-K-2Cl cotransporter is the mechanism of intracellular Cl- accumulation in immature neurons and oligodendrocytes in the white matter is supported.
Journal ArticleDOI
The Role of Chloride Transport in Postsynaptic Inhibition of Hippocampal Neurons
TL;DR: The effects of furosemide suggest that the internal chloride activity of an individual hippocampal neuron is regulated by two transport processes, one that accumulates chloride and one that extrudes chloride.