Journal ArticleDOI
Physiology of cell volume regulation in vertebrates.
TLDR
Current knowledge regarding the molecular identity of these transport pathways and their regulation by, e.g., membrane deformation, ionic strength, Ca(2+), protein kinases and phosphatases, cytoskeletal elements, GTP binding proteins, lipid mediators, and reactive oxygen species are reviewed.Abstract:
The ability to control cell volume is pivotal for cell function. Cell volume perturbation elicits a wide array of signaling events, leading to protective (e.g., cytoskeletal rearrangement) and adap...read more
Citations
More filters
Journal ArticleDOI
Gasdermins: Effectors of Pyroptosis
Stephen B. Kovacs,Edward A. Miao +1 more
TL;DR: The current understanding of pyroptosis as well as current knowledge of the gasdermin family are reviewed.
Journal ArticleDOI
Programmed cell death as a defence against infection.
TL;DR: The role of different cell death pathways in innate immune defence against bacterial and viral infection is discussed: apoptosis, necroptosis, pyroptosis and NETosis, which create complex signalling networks that cross-guard each other in the evolutionary 'arms race' with pathogens.
Journal ArticleDOI
The cytoplasm of living cells behaves as a poroelastic material
Emad Moeendarbary,Léo Valon,Léo Valon,Marco Fritzsche,Marco Fritzsche,Andrew R. Harris,Andrew R. Harris,Dale Moulding,Adrian J. Thrasher,Eleanor Stride,Lakshminarayanan Mahadevan,Guillaume Charras,Guillaume Charras +12 more
TL;DR: The poroelastic model is directly validated to explain cellular rheology at physiologically relevant timescales using microindentation tests in conjunction with mechanical, chemical and genetic treatments and shows that water redistribution through the solid phase of the cytoplasm (cytoskeleton and macromolecular crowders) plays a fundamental role in setting cellularRheology.
Journal ArticleDOI
The functional network of ion channels in T lymphocytes
TL;DR: The expression pattern of Ca2+ and K+ channels and hence the functional network can adapt depending upon the state of differentiation and activation, and this allows for different stages of an immune response to be targeted specifically.
References
More filters
Book
Free radicals in biology and medicine
TL;DR: 1. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species, and the chemistry of free radicals and related 'reactive species'
Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Journal ArticleDOI
Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
Journal ArticleDOI
Free Radicals in the Physiological Control of Cell Function
TL;DR: There is growing evidence that aging involves, in addition, progressive changes in free radical-mediated regulatory processes that result in altered gene expression.
Journal ArticleDOI
Lipid rafts and signal transduction
Kai Simons,Derek Toomre +1 more
TL;DR: It is now becoming clear that lipid micro-environments on the cell surface — known as lipid rafts — also take part in this process of signalling transduction, where protein–protein interactions result in the activation of signalling cascades.