Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
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TLDR
In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.About:
This article is published in Journal of Clinical Epidemiology.The article was published on 1993-11-01. It has received 1291 citations till now. The article focuses on the topics: Adverse drug reaction.read more
Citations
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Journal ArticleDOI
Drug-induced liver injury associated with complementary and alternative medicine: a review of adverse event reports in an Asian community from 2009 to 2014
Desmond Chun Hwee Teo,Patricia Suet Leng Ng,Siew Har Tan,Adena Theen Lim,Dorothy Toh,Sui Yung Chan,Han Hui Cheong,Han Hui Cheong +7 more
TL;DR: H hepatotoxicity cases associated with CAM in Singapore based on spontaneous adverse event reporting to the Health Sciences Authority (HSA) are analyzed to highlight safety signals for specific herbal ingredients and to facilitate future analyses and the understanding of risk-benefit profiles of CAM.
Book ChapterDOI
Drug-Induced Liver Injury: Introduction and Overview
TL;DR: Over the three editions of this book, the field has seen the field shift from a focus on drug metabolism to cellular pathways of injury to the innate immune/inflammatory system to the current and future focus on the adaptive immune system.
Journal ArticleDOI
Hospital Admissions for Drug-Induced Liver Injury: Clinical Features, Therapy, and Outcomes
TL;DR: It is concluded that step-down steroid therapy for DILI improved curative effect, shortened disease course, and was safe.
Journal ArticleDOI
The mystery of the Hawaii liver disease cluster in summer 2013: A pragmatic and clinical approach to solve the problem.
Rolf Teschke,Alexander Schwarzenboeck,Christian Frenzel,Johannes Schulze,Axel Eickhoff,Albrecht Wolff +5 more
TL;DR: The Hawaii liver disease cluster is now best explained by various liver diseases rather than any DS, including OEP, as the updated CIOMS scale confirmed the lack of evidence for any DS including O EP as culprit for the cluster.
Journal ArticleDOI
Black cohosh hepatotoxicity: quantitative causality evaluation in nine suspected cases.
TL;DR: The present study shows little, if any, hepatotoxic risks by the use of BC in the analyzed cases, and a lack of significant circumstantial evidence.
References
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Journal Article
Imputation of the unexpected or toxic effects of drugs. Actualization of the method used in France
Journal ArticleDOI
Causality assessment of adverse reactions to drugs--II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge.
TL;DR: It is concluded that adverse drug reaction reports with a positive rechallenge can provide a standard for validation of causality assessment methods, and RUCAM applied to drug-induced liver injuries has been validated.
Journal ArticleDOI
An Algorithm for the Operational Assessment of Adverse Drug Reactions: I. Background, Description, and Instructions for Use
TL;DR: An algorithm is developed that provides detailed operational criteria for ranking the probability of causation when ADR is suspected between a drug and a clinical manifestation.
Journal ArticleDOI
Toward the operational identification of adverse drug reactions.
Fred E. Karch,Louis Lasagna +1 more
TL;DR: A decision table algorithm approach is presented toward the development of an operational system for the identification of adverse drug reactions that incorporates an estimate of the certainty of the link between the untoward clinical event and the suspect drug, and examines the underlying causes of the identified drug reactions.
Journal ArticleDOI
Assessing methods for causality assessment of suspected adverse drug reactions
Tom A. Hutchinson,David A. Lane +1 more
TL;DR: Six alternative criteria are described that attempt to address a potential user's main concerns--the need to know whether to believe the results in general and in a particular case and focus on the internal structure of a method rather than its output.
Related Papers (5)
Drug-Induced Liver Injury: An Analysis of 461 Incidences Submitted to the Spanish Registry Over a 10-Year Period
Raúl J. Andrade,M. Isabel Lucena,M. Carmen Fernández,G. Pelaez,Ketevan Pachkoria,Elena García-Ruiz,B. García-Muñoz,Rocío González-Grande,Angeles Pizarro,José Antonio Durán,Manuel Jimenez,Luis Rodrigo,Manuel Romero-Gómez,J.M. Navarro,Ramon Planas,Joan Costa,Africa Borras,Aina Soler,Javier Salmerón,Rafael Martín-Vivaldi +19 more