Journal ArticleDOI
Causality assessment of adverse reactions to drugs--I. A novel method based on the conclusions of international consensus meetings: application to drug-induced liver injuries.
Gaby Danan,Christian Bénichou +1 more
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In this paper, a new method for drug causality assessment is described and applied to reports of acute liver injuries, using reports with positive rechallenge as external standard.About:
This article is published in Journal of Clinical Epidemiology.The article was published on 1993-11-01. It has received 1291 citations till now. The article focuses on the topics: Adverse drug reaction.read more
Citations
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Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs
Thomas J. Urban,Yufeng Shen,Andrew Stolz,Naga Chalasani,Robert J. Fontana,James Rochon,Dongliang Ge,Kevin V. Shianna,Ann K. Daly,M. Isabel Lucena,Matthew R. Nelson,Mariam Molokhia,Guruprasad P. Aithal,Aris Floratos,Itsik Pe'er,Jose Serrano,Herbert L. Bonkovsky,Herbert L. Bonkovsky,Timothy J. Davern,William M. Lee,Victor Navarro,Jayant A. Talwalkar,David Goldstein,Paul B. Watkins +23 more
TL;DR: The lack of genome-wide association study findings supports the idea that strong genetic determinants of DILI may be largely drug-specific or may reflect rare genetic variations, which were not assessed in this study.
Journal ArticleDOI
Liver physiology and liver diseases in the elderly
Kazuto Tajiri,Yukihiro Shimizu +1 more
TL;DR: Collectively, aged patients show various changes of the liver and other organs that could affect the clinical characteristics and management of liver diseases in these patients.
Journal ArticleDOI
Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics
Miren García-Cortés,Mercedes Robles-Díaz,Aida Ortega-Alonso,Inmaculada Medina-Caliz,Raúl J. Andrade +4 more
TL;DR: Different DS associated with liver injury are described, some of them manufactured DS containing several ingredients while others have a single ingredient, and illicit androgenic anabolic steroids for bodybuilding are included in this work.
Journal ArticleDOI
Review article: drug-induced liver injury in clinical practice
TL;DR: A review of the recent data on DILI with particular focus on the most common and relevant issues seen in clinical practice is provided, to increase the understanding of liver injury associated with drugs.
Journal ArticleDOI
Troglitazone and liver injury: in search of answers.
TL;DR: The scientific merits of the proposed mechanisms of TGZ hepatotoxicity are evaluated, and alternative explanations are suggested to suggest alternative explanations.
References
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Journal Article
Imputation of the unexpected or toxic effects of drugs. Actualization of the method used in France
Journal ArticleDOI
Causality assessment of adverse reactions to drugs--II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge.
TL;DR: It is concluded that adverse drug reaction reports with a positive rechallenge can provide a standard for validation of causality assessment methods, and RUCAM applied to drug-induced liver injuries has been validated.
Journal ArticleDOI
An Algorithm for the Operational Assessment of Adverse Drug Reactions: I. Background, Description, and Instructions for Use
TL;DR: An algorithm is developed that provides detailed operational criteria for ranking the probability of causation when ADR is suspected between a drug and a clinical manifestation.
Journal ArticleDOI
Toward the operational identification of adverse drug reactions.
Fred E. Karch,Louis Lasagna +1 more
TL;DR: A decision table algorithm approach is presented toward the development of an operational system for the identification of adverse drug reactions that incorporates an estimate of the certainty of the link between the untoward clinical event and the suspect drug, and examines the underlying causes of the identified drug reactions.
Journal ArticleDOI
Assessing methods for causality assessment of suspected adverse drug reactions
Tom A. Hutchinson,David A. Lane +1 more
TL;DR: Six alternative criteria are described that attempt to address a potential user's main concerns--the need to know whether to believe the results in general and in a particular case and focus on the internal structure of a method rather than its output.
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Raúl J. Andrade,M. Isabel Lucena,M. Carmen Fernández,G. Pelaez,Ketevan Pachkoria,Elena García-Ruiz,B. García-Muñoz,Rocío González-Grande,Angeles Pizarro,José Antonio Durán,Manuel Jimenez,Luis Rodrigo,Manuel Romero-Gómez,J.M. Navarro,Ramon Planas,Joan Costa,Africa Borras,Aina Soler,Javier Salmerón,Rafael Martín-Vivaldi +19 more