Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans.
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It is demonstrated chitosan is necessary for virulence and persistence in the mammalian host in Cryptococcus neoformans.Abstract:
Cryptococcus neoformans is an opportunistic fungal pathogen that causes meningoencephalitis. Its cell wall is composed of glucans, proteins, chitin, and chitosan. Multiple genetic approaches have defined a chitosan-deficient syndrome that includes slow growth and decreased cell integrity. Here we demonstrate chitosan is necessary for virulence and persistence in the mammalian host.read more
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Journal ArticleDOI
The Fungal Cell Wall : Structure, Biosynthesis, and Function
TL;DR: Recent advances in research investigating the composition, synthesis, and regulation of cell walls are discussed and how the cell wall is targeted by immune recognition systems and the design of antifungal diagnostics and therapeutics are discussed.
Book ChapterDOI
Fungal Cell Wall Organization and Biosynthesis
TL;DR: The composition and organization of the cell walls from Saccharomyces cerevisiae, Candida albicans, Aspergillus fumigatus, Schizosaccharomysts pombe, Neurospora crassa, and Cryptococcus neoformans are compared and contrasted as discussed by the authors.
Journal ArticleDOI
The role of the cell wall in plant immunity.
TL;DR: This review describes the major molecular and cellular mechanisms that underlie the roles of cell walls in plant defense against pathogen attack, and briefly describes the analytical potential of molecular probes used in conjunction with carbohydrate microarray technology.
Journal ArticleDOI
The Fungal Cell Wall: Candida, Cryptococcus, and Aspergillus Species.
TL;DR: Recent data on the composition and synthesis, influence of the components of the cell wall in fungi-host interaction and the role as a target for the next generation of antifungal drugs in yeasts and filamentous fungi are reviewed.
References
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Aspergillus fumigatus and Aspergillosis
TL;DR: This review focuses on the biology of A. fumigatus, one of the most ubiquitous of the airborne saprophytic fungi, and the diseases it causes, and discusses discussions of genomic and molecular characterization of the organism.
Aspergillus fumigatus and aspergillosis.
TL;DR: A review of the biology of Aspergillus fumigatus and the diseases it causes can be found in this article, where the authors discuss genomic and molecular characterization of the organism, clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunOCompromised hosts, identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and problems associated with antifungal therapy.
Journal ArticleDOI
Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS.
Benjamin J. Park,Kathleen Wannemuehler,Barbara J. Marston,Nelesh P. Govender,Peter G. Pappas,Tom Chiller +5 more
TL;DR: The first attempt to estimate the global burden of cryptococcal meningitis finds the number of cases and deaths to be very high, with most occurring in sub-Saharan Africa.