Journal ArticleDOI
Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness.
James P. Herman,Helmer F. Figueiredo,Nancy K. Mueller,Yvonne M. Ulrich-Lai,Michelle M. Ostrander,Dennis C. Choi,William E. Cullinan +6 more
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The principle extrinsic and intrinsic mechanisms responsible for regulating stress-responsive CRH neurons of the hypothalamic paraventricular nucleus, which summate excitatory and inhibitory inputs into a net secretory signal at the pituitary gland, are reviewed.About:
This article is published in Frontiers in Neuroendocrinology.The article was published on 2003-07-01. It has received 1537 citations till now.read more
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Stress and the brain: from adaptation to disease
TL;DR: In response to stress, the brain activates several neuropeptide-secreting systems, which eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators as mentioned in this paper.
Journal ArticleDOI
Neural regulation of endocrine and autonomic stress responses.
TL;DR: The survival and well-being of all species requires appropriate physiological responses to environmental and homeostatic challenges, so that the respective contributions of the neuroendocrine and autonomic systems are tuned in accordance with stressor modality and intensity.
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The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress.
Sean M. Smith,Wylie Vale +1 more
TL;DR: The role of the HPA axis in the integration of adaptive responses to stress is discussed and the major neuronal and endocrine systems that contribute to the regulation of theHPA axis and the maintenance of homeostasis in the face of aversive stimuli are identified.
Journal ArticleDOI
Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis.
TL;DR: The influence of the limbic system on the HPA axis is likely the end result of the overall patterning of responses to given stimuli and glucocorticoids, with the magnitude of the secretory response determined with respect to the relative contributions of the various structures.
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The cortisol awakening response (CAR): Facts and future directions
TL;DR: It is hypothesized that the anticipation of the upcoming day is of major relevance for the magnitude of the cortisol awakening response, and considerations are addressed concerning the exact function of the CAR.
References
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How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions.
TL;DR: This review considers recent findings regarding GC action and generates criteria for determining whether a particular GC action permits, stimulates, or suppresses an ongoing stress-response or, as an additional category, is preparative for a subsequent stressor.
Book
The rat nervous system
TL;DR: The present work focuses on the development of brain Stem Systems Involved in the Blink Reflex, Feeding Mechanisms, and Micturition of the Spinal Cord, which are involved in the selection of somatic and emotional components of the Motor System in Mammals.
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Stress, adaptation, and disease. Allostasis and allostatic load.
TL;DR: The relationship of allostatic load to genetic and developmental predispositions to disease is considered and examples will be given from research pertaining to autonomic, CNS, neuroendocrine, and immune system activity.
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Book reviewHandbook of Chemical Neuroanatomy: Methods in Chemical Neuroanatomy. Edited by A. Bjorklund and T. Hokfelt. Elsevier, Amsterdam, 1983. Cloth bound, 548 pp. UK £140. (Volume 1 in the series).
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Stress and the Individual: Mechanisms Leading to Disease
Bruce S. McEwen,Eliot Stellar +1 more
TL;DR: A new formulation of the relationship between stress and the processes leading to disease is presented, emphasizing the cascading relationships between environmental factors and genetic predispositions that lead to large individual differences in susceptibility to stress and, in some cases, to disease.