Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial
Peder L. Myhre,Are A Kalstad,Sjur H Tveit,Kristian Laake,Erik Berg Schmidt,Pål Smith,Dennis W.T. Nilsen,Arnljot Tveit,Svein Solheim,Harald Arnesen,Ingebjørg Seljeflot +10 more
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TLDR
The cardiovascular benefit from n‐3 polyunsaturated fatty acids (PUFAs) after acute myocardial infarction (AMI) is controversial, and the importance of serum eicosapentaenoic acid (EPA) and docosahexaenoic Acid (DHA) concentrations for clinical events is unclear.Abstract:
The cardiovascular benefit from n‐3 polyunsaturated fatty acids (PUFAs) after acute myocardial infarction (AMI) is controversial, and the importance of serum eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) concentrations for clinical events is unclear.read more
Citations
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Omega-3 and cardiovascular prevention - is this still a choice?
TL;DR: In this article , the authors discuss the most recent large trials with ω-3 fatty acids (FAs) trying to elucidate mechanistic and trial-related differences, as in the case of REDUCE-IT and STRENGTH studies.
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Omega-3 Fatty Acids in Cardiovascular Disease and Diabetes: a Review of Recent Evidence
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Do omega-3 fatty acids increase risk of atrial fibrillation?
TL;DR: In this paper , the authors summarized the findings from recent observational follow-up studies and randomized trials of plant- and marine omega-3 fatty acids on the risk of atrial fibrillation (AF).
Journal ArticleDOI
Do omega-3 fatty acids increase risk of atrial fibrillation?
TL;DR: In this paper , the authors summarized the findings from recent observational follow-up studies and randomized trials of plant and marine omega-3 fatty acids on the risk of atrial fibrillation (AF).
Posted ContentDOI
Epigenetic biomarkers of autoimmune risk and protective antioxidant signaling in methylmercury-exposed adults
Caren Weinhouse,Luiza Perez,Ian T. Ryde,Jaclyn M. Goodrich,J. Jaime Miranda,Heileen Hsu-Kim,Susan K. Murphy,Joel N. Meyer,William Pan +8 more
TL;DR: A set of candidate epigenetic biomarkers for assessing individualized risk of autoimmune response and protection against neurotoxicity due to MeHg exposure and fish consumption are identified and may inform surrogate tissue biomarkers of early MeHG exposure-related neurotoxicity and T2D risk.
References
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Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
TL;DR: Dietary supplementation with n-3 PUFA led to a clinically important and statistically significant benefit and vitamin E had no benefit and its effects on fatal cardiovascular events require further exploration.
Journal ArticleDOI
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
Mitsuhiro Yokoyama,Hideki Origasa,Masunori Matsuzaki,Yuji Matsuzawa,Yasushi Saito,Yuichi Ishikawa,Shinichi Oikawa,Jun Sasaki,Hitoshi Hishida,Hiroshige Itakura,Toru Kita,Akira Kitabatake,Noriaki Nakaya,Toshiie Sakata,Kazuyuki Shimada,Kunio Shirato +15 more
TL;DR: Testing the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish found it to be a promising treatment.
Journal ArticleDOI
Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia
Deepak L. Bhatt,P. Gabriel Steg,Michael Miller,Eliot A. Brinton,Terry A. Jacobson,Steven B. Ketchum,Ralph T. Doyle,Rebecca A. Juliano,Lixia Jiao,Craig Granowitz,Jean-Claude Tardif,Christie M. Ballantyne,Reduce-It Investigators +12 more
TL;DR: Among patients with elevated triglyceride levels despite the use of statins, the risk of ischemic events, including cardiovascular death, was significantly lower among those who received 2 g of icosapent ethyl twice daily than amongThose who received placebo.
Journal ArticleDOI
BLOOD LEVELS OF LONG-CHAIN n-3 FATTY ACIDS AND THE RISK OF SUDDEN DEATH
Christine M. Albert,Hannia Campos,Meir J. Stampfer,Paul M. Ridker,JoAnn E. Manson,Walter C. Willett,Jing Ma +6 more
TL;DR: The n-3 fatty acids found in fish are strongly associated with a reduced risk of sudden death among men without evidence of prior cardiovascular disease.
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N-3 fatty acids and cardiovascular events after myocardial infarction.
TL;DR: Low-dose supplementation with EPA-DHA or ALA did not significantly reduce the rate of major cardiovascular events among patients who had had a myocardial infarction and who were receiving state-of-the-art antihypertensive, antithrombotic, and lipid-modifying therapy.